HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: CYTSB (Q5M775)
Cytospin-B (Nuclear structure protein 5) (NSP5) (Sperm antigen HCMOGT-1) (Sperm antigen with calponin homology and coiled-coil domains 1)
Gene: SPECC1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	12577067
Identification Methods	pull down
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0030036 - actin cytoskeleton organization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 217 Hs			1 1068
+	Hs
		924666 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		MYH14_HUMAN (366-799): 4.09e-49: 193: 20.33
+	Hs
		725134 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		MYH10_HUMAN (120-977): 3.57e-39: 161: 10.29
+	Hs
		521521 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		ACTN1_HUMAN (960-1067): 7.16e-33: 139: 40.37
+	Hs
		724756 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		MYH9_HUMAN (34-584): 1.32e-23: 110: 9.16
+	Hs
		1078836 ITSN1_HUMAN (137-216): 1.36e-12: 68.1: 25.00		CYTSB_HUMAN (1-1068): 5.36e-72: 262: 100.00
+	Hs
		433808 LYN_HUMAN (129-215): 1.44e-11: 65: 22.47		CYTSB_HUMAN (1-1068): 5.36e-72: 262: 100.00
+	Hs
		728465 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		MYH11_HUMAN (487-993): 4.15e-16: 86.1: 11.83
+	Hs
		211557 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		ACTN4_HUMAN (963-1066): 6.3e-15: 81.6: 41.91
+	Hs
		924637 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		CYTSA_HUMAN (1-389): 7.43e-11: 68.7: 7.36
+	Hs
		993249 PTK6_HUMAN (4-141): 7.14e-23: 97.1: 38.93		ACTN3_HUMAN (960-1066): 1.62e-47: 186: 39.82
+	Hs
		1078856 ITSN1_HUMAN (137-216): 1.36e-12: 68.1: 25.00		MYH14_HUMAN (366-799): 4.09e-49: 193: 20.33
+	Hs
		433889 LYN_HUMAN (129-215): 1.44e-11: 65: 22.47		MILK1_HUMAN (963-1066): 1.29e-35: 148: 40.00
+	Ce
		110517 SEM5_CAEEL (3-69): 6.24e-14: 70: 28.36		H2L2C8_CAEEL (960-1067): 8.63e-34: 142: 41.67
+	Ce
		666217 SEM5_CAEEL (3-69): 6.24e-14: 70: 28.36		Q23158_CAEEL (960-1068): 1.34e-32: 138: 40.37
+	Hs
		412058 FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58		MYH9_HUMAN (34-584): 1.32e-23: 110: 9.16
+	Hs
		111443 J3QRU1_HUMAN (52-215): 3.95e-13: 69.6: 14.29		MYH9_HUMAN (34-584): 1.32e-23: 110: 9.16
+	Hs
		433272 YES_HUMAN (59-215): 4.17e-13: 69.2: 14.91		MYH9_HUMAN (34-584): 1.32e-23: 110: 9.16
+	Hs
		433620 LYN_HUMAN (129-215): 1.44e-11: 65: 22.47		MYH9_HUMAN (34-584): 1.32e-23: 110: 9.16
+	Hs
		433853 LYN_HUMAN (129-215): 1.44e-11: 65: 22.47		MICA3_HUMAN (956-1067): 2.33e-14: 80.5: 38.05
+	Hs
		548722 VAV_HUMAN (2-60): 8.95e-15: 74.6: 42.37		CYTSA_HUMAN (1-389): 7.43e-11: 68.7: 7.36