HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: K2C73 (Q86Y46)
Keratin, type II cytoskeletal 73 (Cytokeratin-73) (CK-73) (Keratin-73) (K73) (Type II inner root sheath-specific keratin-K6irs3) (Type-II keratin Kb36)
Gene: KRT73

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	19380743
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0070062 - extracellular exosome
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 217 Hs			1 540
+	Hs
		380590 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		K2C1_HUMAN (97-463): 2.77e-157: 464: 66.76
+	Hs
		444533 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		K2C7_HUMAN (17-459): 1.09e-141: 418: 57.34
+	Hs
		409046 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		K2C8_HUMAN (104-467): 2.16e-139: 413: 61.26
+	Hs
		924470 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		KRT85_HUMAN (3-447): 6.42e-94: 297: 49.56
+	Hs
		924576 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		KRT81_HUMAN (3-447): 1.91e-92: 293: 48.76
+	Hs
		924469 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		KRT83_HUMAN (3-495): 2.62e-92: 292: 44.63
+	Hs
		213936 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		KRT86_HUMAN (3-504): 1.09e-91: 291: 44.62
+	Hs
		531551 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		K2C5_HUMAN (1-448): 2.08e-78: 259: 57.65
+	Hs
		359480 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		K2C6A_HUMAN (2-469): 1.45e-75: 251: 57.03
+	Mm
		1060206 GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54		Q148Q7_MOUSE (1-457): 2.26e-67: 228: 56.41
+	Mm
		1141145 GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54		Q8BIS2_MOUSE (1-457): 1.79e-67: 228: 56.41
+	Hs
		924741 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		KRT35_HUMAN (35-445): 8.84e-68: 227: 25.49
+	Hs
		924575 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		K1H2_HUMAN (46-445): 1.83e-67: 226: 21.25
+	Mm
		403456 SRC_MOUSE (161-215): 3.76e-11: 63.8: 31.58		K2C5_MOUSE (1-460): 2.88e-75: 250: 56.94
+	Hs
		924895 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		KRT82_HUMAN (178-499): 2.94e-11: 68: 11.38
+	Hs
		442865 HCK_HUMAN (120-215): 1.21e-12: 68.1: 19.39		KRT35_HUMAN (35-445): 8.84e-68: 227: 25.49