HitPredict

Interactor 1: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: RHG35 (Q9NRY4)
Rho GTPase-activating protein 35 (Glucocorticoid receptor DNA-binding factor 1) (Glucocorticoid receptor repression factor 1) (GRF-1) (Rho GAP p190A) (p190-A)
Gene: ARHGAP35

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	22505611, 12441060
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 217 Hs			1 1499
+	Hs
		924608 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		Q1RLN5_HUMAN (1009-1436): 8.93e-77: 274: 20.96
+	Hs
		924686 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		RHG12_HUMAN (1009-1436): 4.11e-76: 273: 20.96
+	Hs
		64687 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		RHG32_HUMAN (1199-1478): 3.27e-67: 253: 21.09
+	Hs
		200212 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		SRGP3_HUMAN (1086-1488): 4.16e-67: 250: 18.72
+	Hs
		924852 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		RGAP1_HUMAN (1043-1487): 8.98e-68: 243: 16.88
+	Hs
		924636 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		RHG17_HUMAN (1208-1497): 7.87e-63: 234: 23.81
+	Hs
		69699 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		B1AHC3_HUMAN (1063-1494): 7.19e-65: 233: 19.73
+	Hs
		411755 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		RHG21_HUMAN (1032-1487): 7.82e-72: 268: 21.08
+	Hs
		64641 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		RHG32_HUMAN (1199-1478): 3.27e-67: 253: 21.09
+	Hs
		411763 LCK_HUMAN (3-202): 3.69e-37: 137: 28.91		RHG17_HUMAN (1208-1497): 7.87e-63: 234: 23.81
+	Hs
		557714 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		RHG21_HUMAN (1032-1487): 7.82e-72: 268: 21.08
+	Hs
		337453 ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46		ABR_HUMAN (866-1441): 3.75e-73: 265: 17.77
+	Hs
		557642 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		CHIO_HUMAN (1034-1436): 1.18e-76: 264: 22.11
+	Hs
		551038 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		CHIN_HUMAN (1034-1436): 1.75e-75: 260: 23.10
+	Hs
		64651 NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14		RHG32_HUMAN (1199-1478): 3.27e-67: 253: 21.09
+	Mm
		763398 FYN_MOUSE (161-215): 4.44e-14: 72.3: 31.58		RHG33_MOUSE (1152-1498): 2e-72: 268: 20.94
+	Hs
		154775 GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00		TCRG1_HUMAN (227-602): 5.14e-21: 102: 12.58
+	Hs
		337492 ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46		RHG17_HUMAN (1208-1497): 7.87e-63: 234: 23.81
+	Hs
		548749 VAV_HUMAN (2-60): 8.95e-15: 74.6: 42.37		RGAP1_HUMAN (1043-1487): 8.98e-68: 243: 16.88
+	Ce
		220207 SRC2_CAEEL (118-215): 1.65e-14: 73.4: 22.00		TG325_CAEEL (1209-1404): 3.38e-23: 109: 34.48