HitPredict

Interactor 1: TRA2B (P62995)
Transformer-2 protein homolog beta (TRA-2 beta) (TRA2-beta) (hTRA2-beta) (Splicing factor, arginine/serine-rich 10) (Transformer-2 protein homolog B)
Gene: TRA2B

Interactor 2: SRSF1 (Q07955)
Serine/arginine-rich splicing factor 1 (Alternative-splicing factor 1) (ASF-1) (Splicing factor, arginine/serine-rich 1) (pre-mRNA-splicing factor SF2, P33 subunit)
Gene: SRSF1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.71	1.00	0.843

Property	Details
Experiments	24981860, 32296183, unassigned1304
Identification Methods	affinity chromatography technology, two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0003723 - RNA binding GO:0003729 - mRNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm and 1 others more... GO:0043484 - regulation of RNA splicing
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 288 Hs			1 248
+	Hs
		1028541 TRA2A_HUMAN (1-237): 9.33e-36: 131: 62.06		SRSF9_HUMAN (1-239): 2.72e-66: 206: 60.25
+	Hs
		925020 TRA2B_HUMAN (1-267): 9.15e-34: 126: 100.00		SRSF9_HUMAN (1-239): 2.72e-66: 206: 60.25
+	Mm
		925167 TRA2B_MOUSE (1-267): 9.15e-34: 126: 100.00		SRSF9_MOUSE (2-239): 1.21e-65: 204: 58.82
+	Hs
		1028644 TRA2A_HUMAN (1-237): 9.33e-36: 131: 62.06		SRSF5_HUMAN (14-183): 8.03e-61: 194: 41.48
+	Mm
		192621 TRA2B_MOUSE (1-267): 9.15e-34: 126: 100.00		SRSF5_MOUSE (14-183): 7.35e-61: 194: 41.48
+	Hs
		1028895 TRA2A_HUMAN (1-237): 9.33e-36: 131: 62.06		SRSF6_HUMAN (17-200): 2.58e-57: 187: 40.51
+	Hs
		925021 TRA2B_HUMAN (1-267): 9.15e-34: 126: 100.00		SRSF6_HUMAN (17-200): 2.58e-57: 187: 40.51
+	Hs
		993707 TRA2A_HUMAN (1-237): 9.33e-36: 131: 62.06		SRSF4_HUMAN (17-243): 1.36e-49: 171: 37.66
+	Hs
		925012 TRA2B_HUMAN (1-267): 9.15e-34: 126: 100.00		SRSF4_HUMAN (17-243): 1.36e-49: 171: 37.66
+	Hs
		992758 TRA2A_HUMAN (1-237): 9.33e-36: 131: 62.06		SRSF1_HUMAN (1-235): 1.04e-49: 165: 100.00
+	Hs
		516502 TRA2A_HUMAN (1-237): 9.33e-36: 131: 62.06		PABP1_HUMAN (8-203): 7.41e-38: 141: 16.67
+	Hs
		516451 TRA2B_HUMAN (1-267): 9.15e-34: 126: 100.00		PABP1_HUMAN (8-203): 7.41e-38: 141: 16.67
+	Mm
		1161322 TRA2A_MOUSE (1-237): 2.38e-35: 130: 61.18		SRSF7_MOUSE (11-105): 2e-26: 105: 40.00
+	Hs
		925003 TRA2B_HUMAN (1-267): 9.15e-34: 126: 100.00		SRSF3_HUMAN (15-99): 9.33e-28: 105: 43.53
+	Mm
		925159 TRA2B_MOUSE (1-267): 9.15e-34: 126: 100.00		SRSF3_MOUSE (15-99): 9.33e-28: 105: 43.53
+	Hs
		1040334 TRA2A_HUMAN (1-237): 9.33e-36: 131: 62.06		SRSF7_HUMAN (14-105): 7.34e-23: 94.8: 40.22
+	Hs
		925048 TRA2B_HUMAN (1-267): 9.15e-34: 126: 100.00		SRSF7_HUMAN (14-105): 7.34e-23: 94.8: 40.22
+	Hs
		474022 TRA2A_HUMAN (1-237): 9.33e-36: 131: 62.06		PAB4L_HUMAN (17-92): 5.07e-19: 86.6: 19.48
+	Hs
		1031314 TRA2A_HUMAN (1-237): 9.33e-36: 131: 62.06		PABP4_HUMAN (118-200): 2.19e-13: 71.2: 16.67
+	Mm
		857303 TRA2B_MOUSE (1-267): 9.15e-34: 126: 100.00		TIA1_MOUSE (115-203): 5.51e-10: 60.8: 11.70