HitPredict

Interactor 1: RAC1 (P63000)
Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (Cell migration-inducing gene 5 protein) (Ras-like protein TC25) (p21-Rac1)
Gene: RAC1

Interactor 2: LRP2 (P98164)
Low-density lipoprotein receptor-related protein 2 (LRP-2) (Glycoprotein 330) (gp330) (Megalin)
Gene: LRP2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	18426980
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0070062 - extracellular exosome
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 192 Hs			1 4655
+	Hs
		564477 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		LRP2_HUMAN (1-4655): 0: 3803: 100.00
+	Hs
		893898 CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31		LRP2_HUMAN (1-4655): 0: 3803: 100.00
+	Hs
		900376 RHOA_HUMAN (5-192): 3.5e-77: 230: 57.98		LRP2_HUMAN (1-4655): 0: 3803: 100.00
+	Hs
		254256 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		LRP4_HUMAN (3839-4093): 6.21e-15: 84.9: 22.90
+	Hs
		258305 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		LRP5_HUMAN (3071-3230): 8.89e-09: 64.5: 12.42
+	Hs
		258292 RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19		LRP5_HUMAN (3071-3230): 8.89e-09: 64.5: 12.42
+	Hs
		270329 RHOJ_HUMAN (2-189): 1.38e-80: 240: 60.64		LRP6_HUMAN (3113-3241): 3.94e-09: 65.6: 16.30
+	Hs
		258347 RHOJ_HUMAN (2-189): 1.38e-80: 240: 60.64		LRP5_HUMAN (3071-3230): 8.89e-09: 64.5: 12.42
+	Hs
		270285 RAC3_HUMAN (1-191): 2.72e-79: 236: 93.19		LRP6_HUMAN (3113-3241): 3.94e-09: 65.6: 16.30
+	Hs
		258302 RAC3_HUMAN (1-191): 2.72e-79: 236: 93.19		LRP5_HUMAN (3071-3230): 8.89e-09: 64.5: 12.42
+	Hs
		258303 CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31		LRP5_HUMAN (3071-3230): 8.89e-09: 64.5: 12.42
+	Hs
		258304 RHOA_HUMAN (5-192): 3.5e-77: 230: 57.98		LRP5_HUMAN (3071-3230): 8.89e-09: 64.5: 12.42