Protein: BRX1
Ribosome biogenesis protein BRX1

Gene: BRX1
Organism: Saccharomyces cerevisiae S288C
Interactions: 184
UniProt ID: Q08235

Gene Ontology (top 5):
GO:0000027 - ribosomal large subunit assembly
GO:0000464 - endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000465 - exonucleolytic trimming to generate mature 5'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0003723 - RNA binding
GO:0005730 - nucleolus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

780332

EBP2
rRNA-processing protein EBP2

10

10

Small-scale

0.976

High

782469

RPF2
Ribosome biogenesis protein RPF2

6

7

Small-scale

0.943

High

1047294

ERB1
Ribosome biogenesis protein ERB1

4

9

High-throughput

0.900

High

805104

RPF1
Ribosome production factor 1

3

8

High-throughput

0.848

High

684863

RL5
Large ribosomal subunit protein uL18

2

6

High-throughput

0.789

High

780717

RRP14
Ribosomal RNA-processing protein 14

2

3

Small-scale

0.757

High

1062786

RRS1
Regulator of ribosome biosynthesis

2

10

Small-scale

0.757

High

804675

SSF1
Ribosome biogenesis protein SSF1

2

11

Small-scale

0.754

High

1055476

RRP15
Ribosomal RNA-processing protein 15

2

4

Small-scale

0.754

High

1050189

RRP5
rRNA biogenesis protein RRP5

7

7

Small-scale

0.746

High

850028

LOC1
60S ribosomal subunit assembly/export protein LOC1

7

4

Small-scale

0.743

High

919024

PESC
Pescadillo homolog

7

6

Small-scale

0.743

High

637294

PWP1
Periodic tryptophan protein 1

5

6

Small-scale

0.720

High

917572

NSA1
Ribosome biogenesis protein NSA1

5

9

Small-scale

0.709

High

1039645

NOG1
Nucleolar GTP-binding protein 1

5

10

Small-scale

0.709

High

814403

NOC2
Nucleolar complex protein 2

5

4

Small-scale

0.707

High

1062799

IF6
Eukaryotic translation initiation factor 6

4

8

Small-scale

0.696

High

830197

NOP2
25S rRNA

4

16

Small-scale

0.694

High

791120

NOP4
Nucleolar protein 4

4

10

Small-scale

0.691

High

924860

NOP15
Ribosome biogenesis protein 15

4

13

High-throughput

0.691

High

1062794

MAK21
Ribosome biogenesis protein MAK21

4

16

High-throughput

0.691

High

682407

SPB4
ATP-dependent rRNA helicase SPB4

4

20

High-throughput

0.686

High

827626

RLP7
Ribosome biogenesis protein RLP7

4

15

Small-scale

0.686

High

1043301

HAS1
ATP-dependent RNA helicase HAS1

4

20

High-throughput

0.686

High

1046529

PUF6
Pumilio homology domain family member 6

4

7

Small-scale

0.686

High

1062797

DBP10
ATP-dependent RNA helicase DBP10

4

17

High-throughput

0.686

High

816806

NOP16
Nucleolar protein 16

3

3

High-throughput

0.658

High

570165

RL3
Large ribosomal subunit protein uL3

3

8

Small-scale

0.656

High

763130

RRP1
Ribosomal RNA-processing protein 1

3

12

Small-scale

0.656

High

803953

CIC1
Proteasome-interacting protein CIC1

3

15

High-throughput

0.656

High

1062341

NOP12
Nucleolar protein 12

3

17

High-throughput

0.656

High

1062787

NIP7
60S ribosome subunit biogenesis protein NIP7

3

7

Small-scale

0.656

High

1062789

YTM1
Ribosome biogenesis protein YTM1

3

11

Small-scale

0.656

High

601142

RL8A
Large ribosomal subunit protein eL8A

3

16

Small-scale

0.640

High

518147

SSBP1
Single-stranded nucleic acid-binding protein

2

3

High-throughput

0.621

High

534154

MAK16
Protein MAK16

1

12

High-throughput

0.618

High

1036303

RL6A
Large ribosomal subunit protein eL6A

1

4

High-throughput

0.618

High

1062793

SSF2
Ribosome biogenesis protein SSF2

1

11

High-throughput

0.618

High

410369

RL25
Large ribosomal subunit protein uL23

2

6

High-throughput

0.611

High

712682

RL8B
Large ribosomal subunit protein eL8B

2

16

High-throughput

0.611

High

746684

DRS1
ATP-dependent RNA helicase DRS1

2

20

High-throughput

0.611

High

750159

MRT4
Ribosome assembly factor MRT4

2

11

High-throughput

0.611

High

816920

NUG1
Nuclear GTP-binding protein NUG1

2

13

High-throughput

0.611

High

1060740

NOC3
Nucleolar complex-associated protein 3

2

12

High-throughput

0.611

High

918842

UTP22
U3 small nucleolar RNA-associated protein 22

2

4

High-throughput

0.588

High

633201

MAK11
Protein MAK11

2

10

Small-scale

0.584

High

798333

ENP1
Essential nuclear protein 1

2

4

High-throughput

0.584

High

1044909

RRP17
Ribosomal RNA-processing protein 17

2

3

High-throughput

0.584

High

1060826

RLP24
Ribosome biogenesis protein RLP24

2

9

Small-scale

0.584

High

1062791

NOP53
Ribosome biogenesis protein NOP53

2

11

High-throughput

0.584

High

807163

FKBP3
Peptidyl-prolyl cis-trans isomerase

2

13

High-throughput

0.576

High

815258

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

4

Small-scale

0.561

High

819981

SSB2
Ribosome-associated molecular chaperone SSB2

2

7

High-throughput

0.549

High

700304

GAR1
H/ACA ribonucleoprotein complex subunit GAR1

1

1

High-throughput

0.541

High

434452

RL15A
Large ribosomal subunit protein eL15A

1

7

High-throughput

0.536

High

806668

RIX1
Pre-rRNA-processing protein RIX1

1

1

High-throughput

0.536

High

817647

UTP7
U3 small nucleolar RNA-associated protein 7

1

7

High-throughput

0.536

High

917495

PRP43
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43

1

3

High-throughput

0.536

High

1060413

RIX7
Ribosome biogenesis ATPase RIX7

1

5

High-throughput

0.536

High

1062795

RL7B
Large ribosomal subunit protein uL30B

1

15

High-throughput

0.536

High

1062800

RL13A
Large ribosomal subunit protein eL13A

1

8

High-throughput

0.536

High

513417

RL23B
Large ribosomal subunit protein uL14B

2

3

Small-scale

0.533

High

963764

H3
Histone H3

2

8

High-throughput

0.533

High

546540

SSB1
Ribosome-associated molecular chaperone SSB1

2

7

High-throughput

0.504

High

666558

DBP2
ATP-dependent RNA helicase DBP2

1

1

High-throughput

0.494

High

722317

XPO1
Exportin-1

1

6

High-throughput

0.489

High

763036

SPT7
SAGA complex subunit SPT7

1

3

High-throughput

0.489

High

893169

IMDH4
Inosine-5'-monophosphate dehydrogenase 4

1

2

High-throughput

0.489

High

923139

BRE5
UBP3-associated protein BRE5

1

2

High-throughput

0.489

High

1027318

AP1M1
AP-1 complex subunit mu-1-I

1

2

High-throughput

0.489

High

1030592

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

2

High-throughput

0.489

High

1042390

GCN5
Histone acetyltransferase GCN5

1

6

High-throughput

0.489

High

704663

SBA1
Co-chaperone protein SBA1

1

2

Small-scale

0.481

High

149986

RS9A
Small ribosomal subunit protein uS4A

1

9

High-throughput

0.479

High

432718

RL7A
Large ribosomal subunit protein uL30A

1

15

High-throughput

0.479

High

433880

RL26A
Large ribosomal subunit protein uL24A

1

10

High-throughput

0.479

High

435403

RS3
Small ribosomal subunit protein uS3

1

5

High-throughput

0.479

High

436205

RS13
Small ribosomal subunit protein uS15

1

4

High-throughput

0.479

High

442141

RS14A
Small ribosomal subunit protein uS11A

1

6

High-throughput

0.479

High

455295

RS19A
Small ribosomal subunit protein eS19A

1

9

High-throughput

0.479

High

512688

RS6A
Small ribosomal subunit protein eS6A

1

9

High-throughput

0.479

High

671193

SIS1
Protein SIS1

1

3

High-throughput

0.479

High

672967

RRP43
Exosome complex component RRP43

1

2

High-throughput

0.479

High

674869

RS2
Small ribosomal subunit protein uS5

1

6

High-throughput

0.479

High

677249

SPB1
27S pre-rRNA

1

9

High-throughput

0.479

High

677592

KRR1
KRR1 small subunit processome component

1

8

High-throughput

0.479

High

678476

PWP2
Periodic tryptophan protein 2

1

5

High-throughput

0.479

High

689699

RS7A
Small ribosomal subunit protein eS7A

1

4

High-throughput

0.479

High

778567

RS27A
Small ribosomal subunit protein eS27A

1

3

High-throughput

0.479

High

781660

DBP7
ATP-dependent RNA helicase DBP7

1

20

High-throughput

0.479

High

793539

MAK5
ATP-dependent RNA helicase MAK5

1

20

High-throughput

0.479

High

795853

YBC8
UPF0642 protein YBL028C

1

2

High-throughput

0.479

High

818286

NSA2
Ribosome biogenesis protein NSA2

1

6

High-throughput

0.479

High

844642

UTP10
U3 small nucleolar RNA-associated protein 10

1

4

High-throughput

0.479

High

864535

MTR4
ATP-dependent RNA helicase DOB1

1

6

Small-scale

0.479

High

918340

RL26B
Large ribosomal subunit protein uL24B

1

10

High-throughput

0.479

High

923215

NOG2
Nucleolar GTP-binding protein 2

1

13

High-throughput

0.479

High

924199

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

7

High-throughput

0.479

High

924342

NOP13
Nucleolar protein 13

1

5

High-throughput

0.479

High

925451

RCM1
25S rRNA

1

16

High-throughput

0.479

High

1033602

RS15
Small ribosomal subunit protein uS19

1

3

High-throughput

0.479

High

1038765

XRN2
5'-3' exoribonuclease 2

1

3

High-throughput

0.479

High

1046064

DHR1
Probable ATP-dependent RNA helicase DHR1

1

5

High-throughput

0.479

High

1046123

RRB1
Ribosome assembly protein RRB1

1

7

High-throughput

0.479

High

1046810

UTP14
U3 small nucleolar RNA-associated protein 14

1

5

High-throughput

0.479

High

1054257

FKBP4
FK506-binding protein 4

1

13

High-throughput

0.479

High

1054370

JIP5
WD repeat-containing protein JIP5

1

7

High-throughput

0.479

High

1054407

DBP9
ATP-dependent RNA helicase DBP9

1

14

High-throughput

0.479

High

1055502

NOC4
Nucleolar complex protein 4

1

16

High-throughput

0.479

High

1062782

REXO4
RNA exonuclease 4

1

7

High-throughput

0.479

High

1062785

RS10A
Small ribosomal subunit protein eS10A

1

6

High-throughput

0.479

High

1062788

BMS1
Ribosome biogenesis protein BMS1

1

2

High-throughput

0.479

High

1062792

RRP6
Exosome complex exonuclease RRP6

1

2

High-throughput

0.479

High

1062798

NOP58
Nucleolar protein 58

1

14

High-throughput

0.479

High

657006

BUR1
Serine/threonine-protein kinase BUR1

1

2

High-throughput

0.470

High

1054164

PDP3
NuA3 HAT complex component PDP3

1

1

High-throughput

0.470

High

1062784

ESA1
Histone acetyltransferase ESA1

1

3

Small-scale

0.457

High

1062796

PKH2
Serine/threonine-protein kinase PKH2

1

3

High-throughput

0.457

High

427462

RLA0
Large ribosomal subunit protein uL10

1

11

High-throughput

0.445

High

531911

RL4A
Large ribosomal subunit protein uL4A

1

11

High-throughput

0.445

High

1025195

SEN1
Helicase SEN1

1

5

Small-scale

0.445

High

382388

H4
Histone H4

1

5

High-throughput

0.437

High

383925

RS17A
Small ribosomal subunit protein eS17A

1

4

High-throughput

0.437

High

403678

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

1

5

Small-scale

0.437

High

419895

H2A2
Histone H2A.2

1

8

High-throughput

0.437

High

436538

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

7

High-throughput

0.437

High

449020

TOP2
DNA topoisomerase 2

1

1

High-throughput

0.437

High

503276

RS22A
Small ribosomal subunit protein uS8A

1

6

High-throughput

0.437

High

503856

RL27A
Large ribosomal subunit protein eL27A

1

4

High-throughput

0.437

High

504447

RL31A
Large ribosomal subunit protein eL31A

1

9

High-throughput

0.437

High

511306

RL20B
Large ribosomal subunit protein eL20B

1

7

High-throughput

0.437

High

511497

RL43B
Large ribosomal subunit protein eL43B

1

8

Small-scale

0.437

High

513255

RS8A
Small ribosomal subunit protein eS8A

1

6

High-throughput

0.437

High

514866

RS18A
Small ribosomal subunit protein uS13A

1

4

High-throughput

0.437

High

558885

CAF20
Cap-associated protein CAF20

1

1

High-throughput

0.437

High

646554

RAD53
Serine/threonine-protein kinase RAD53

1

2

High-throughput

0.437

High

680117

CDC48
Cell division control protein 48

1

5

High-throughput

0.437

High

708379

TF2B
Transcription initiation factor IIB

1

7

High-throughput

0.437

High

708795

TF3B
Transcription factor IIIB 70 kDa subunit

1

7

High-throughput

0.437

High

710019

BMH1
Protein BMH1

1

1

High-throughput

0.437

High

735201

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

4

High-throughput

0.437

High

744352

CHD1
Chromo domain-containing protein 1

1

5

High-throughput

0.437

High

747612

RSSA1
Small ribosomal subunit protein uS2A

1

8

High-throughput

0.437

High

748081

SMY2
Protein SMY2

1

1

High-throughput

0.437

High

753622

RS3A1
Small ribosomal subunit protein eS1A

1

6

High-throughput

0.437

High

802421

RS20
Small ribosomal subunit protein uS10

1

3

High-throughput

0.437

High

812719

LAA1
AP-1 accessory protein LAA1

1

4

High-throughput

0.437

High

825916

RL34B
Large ribosomal subunit protein eL34B

1

2

High-throughput

0.437

High

826098

ULP2
Ubiquitin-like-specific protease 2

1

3

High-throughput

0.437

High

826892

DSN1
Kinetochore-associated protein DSN1

1

4

High-throughput

0.437

High

918479

EIF2A
Eukaryotic translation initiation factor 2A

1

3

High-throughput

0.437

High

923885

GIS2
Zinc finger protein GIS2

1

6

High-throughput

0.437

High

932241

ORC1
Origin recognition complex subunit 1

1

5

High-throughput

0.437

High

1025055

NUM1
Nuclear migration protein NUM1

1

2

High-throughput

0.437

High

1044315

MTQ2
eRF1 methyltransferase catalytic subunit MTQ2

1

1

High-throughput

0.437

High

1046319

VMS1
tRNA endonuclease VMS1

1

4

High-throughput

0.437

High

1053991

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

4

High-throughput

0.437

High

1054859

TFC6
Transcription factor tau 91 kDa subunit

1

2

High-throughput

0.437

High

1059377

VAM6
Vacuolar morphogenesis protein 6

1

3

High-throughput

0.437

High

1062783

SGO1
Shugoshin

1

5

High-throughput

0.437

High

1062801

H2AZ
Histone H2A.Z

1

7

High-throughput

0.437

High

386886

TBB
Tubulin beta chain

1

1

High-throughput

0.407

High

393443

HSP82
ATP-dependent molecular chaperone HSP82

1

2

High-throughput

0.407

High

394958

EF1A
Elongation factor 1-alpha

1

4

High-throughput

0.407

High

453828

PYR1
Multifunctional protein URA2

1

1

High-throughput

0.407

High

525368

HSP71
Heat shock protein SSA1

1

9

High-throughput

0.407

High

527860

HSP72
Heat shock protein SSA2

1

9

High-throughput

0.407

High

755184

GCN1
eIF-2-alpha kinase activator GCN1

1

5

High-throughput

0.407

High

804513

SSZ1
Ribosome-associated complex subunit SSZ1

1

1

High-throughput

0.407

High

816444

HSP7E
Heat shock protein SSC3, mitochondrial

1

2

High-throughput

0.407

High

863992

JJJ2
J protein JJJ2

1

2

High-throughput

0.407

High

893241

IMDH3
Inosine-5'-monophosphate dehydrogenase 3

1

2

High-throughput

0.407

High

893348

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

5

High-throughput

0.407

High

1051567

RT103
Regulator of Ty1 transposition protein 103

1

0

High-throughput

0.282

High

1062802

YB296
Uncharacterized protein YBR296C-A

1

0

High-throughput

0.282

High

690748

DPB3
DNA polymerase epsilon subunit C

1

0

High-throughput

0.269

Low

645003

RPA2
DNA-directed RNA polymerase I subunit RPA135

1

0

High-throughput

0.249

Low

748567

SC61A
Protein transport protein SEC61

1

0

High-throughput

0.249

Low

1043955

PML39
Pre-mRNA leakage protein 39

1

0

High-throughput

0.249

Low

1046948

POB3
FACT complex subunit POB3

1

0

High-throughput

0.249

Low

592541

VATB
V-type proton ATPase subunit B

1

0

High-throughput

0.232

Low

779449

MAOM
NAD-dependent malic enzyme, mitochondrial

1

0

High-throughput

0.232

Low

1050240

TAF9
SAGA complex/transcription factor TFIID complex subunit TAF9

1

0

High-throughput

0.232

Low

1062790

HFI1
SAGA complex subunit HFI1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025