HitPredict

Interactor 1: RAC1 (P63000)
Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (Cell migration-inducing gene 5 protein) (Ras-like protein TC25) (p21-Rac1)
Gene: RAC1

Interactor 2: RHG27 (Q6ZUM4)
Rho GTPase-activating protein 27 (CIN85-associated multi-domain-containing Rho GTPase-activating protein 1) (Rho-type GTPase-activating protein 27) (SH3 domain-containing protein 20)
Gene: ARHGAP27

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	15147912
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PH~Ras, Ras~RhoGAP
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 192 Hs			1 889
+	Hs
		925329 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		RHG15_HUMAN (424-886): 1.07e-105: 337: 40.55
+	Hs
		551044 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		CHIN_HUMAN (405-886): 1.32e-89: 294: 20.66
+	Hs
		856140 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		CHIO_HUMAN (410-886): 2.41e-88: 290: 20.46
+	Mm
		925793 RAC1_MOUSE (1-192): 3.81e-86: 253: 100.00		ABR_MOUSE (271-886): 4.4e-79: 276: 19.57
+	Hs
		925343 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		RHG21_HUMAN (115-886): 8.91e-76: 273: 17.86
+	Mm
		925802 RAC1_MOUSE (1-192): 3.81e-86: 253: 100.00		CHIO_MOUSE (580-886): 2.47e-82: 270: 24.92
+	Hs
		147862 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		RHG33_HUMAN (633-886): 5.34e-75: 269: 31.32
+	Hs
		925242 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		RHG05_HUMAN (317-886): 1.86e-71: 260: 19.10
+	Hs
		64688 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		RHG32_HUMAN (653-886): 2.1e-70: 256: 31.95
+	Mm
		925803 RAC1_MOUSE (1-192): 3.81e-86: 253: 100.00		RHG32_MOUSE (653-886): 5.01e-70: 255: 31.95
+	Mm
		925805 RAC1_MOUSE (1-192): 3.81e-86: 253: 100.00		RHG22_MOUSE (533-886): 2.64e-67: 239: 22.44
+	Hs
		925345 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		SYDE2_HUMAN (353-883): 1.63e-64: 238: 18.87
+	Hs
		925192 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		RHG04_HUMAN (638-888): 1.13e-64: 236: 27.89
+	Mm
		925798 RAC1_MOUSE (1-192): 3.81e-86: 253: 100.00		BCR_MOUSE (291-867): 2.54e-63: 235: 19.80
+	Hs
		925354 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		RHG17_HUMAN (660-887): 2.38e-62: 229: 27.27
+	Hs
		200213 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		SRGP3_HUMAN (530-887): 1.9e-61: 228: 17.65
+	Hs
		925227 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		RHG01_HUMAN (692-887): 4.34e-64: 224: 26.77
+	Mm
		925791 RAC1_MOUSE (1-192): 3.81e-86: 253: 100.00		RHG01_MOUSE (542-887): 2.83e-61: 216: 17.19
+	Hs
		506566 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		BCR_HUMAN (659-865): 3.31e-30: 130: 40.87
+	Hs
		63073 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		RHG42_HUMAN (713-886): 4.63e-28: 123: 40.11