HitPredict

Interactor 1: RAC1 (P63000)
Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (Cell migration-inducing gene 5 protein) (Ras-like protein TC25) (p21-Rac1)
Gene: RAC1

Interactor 2: IQGA3 (Q86VI3)
Ras GTPase-activating-like protein IQGAP3
Gene: IQGAP3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	1.00	0.847

Property	Details
Experiments	19961560, 27173435, 31871319
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Ras~RasGAP
Common GO terms	GO:0001934 - positive regulation of protein phosphorylation GO:0005829 - cytosol GO:0005938 - cell cortex GO:0008361 - regulation of cell size
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 192 Hs			1 1631
+	Hs
		564593 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		IQGA3_HUMAN (1-1631): 0: 1709: 100.00
+	Hs
		809255 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		IQGA1_HUMAN (6-1631): 0: 1574: 58.99
+	Hs
		564448 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		IQGA1_HUMAN (6-1631): 0: 1574: 58.99
+	Hs
		545255 RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19		IQGA1_HUMAN (6-1631): 0: 1574: 58.99
+	Mm
		925821 RAC1_MOUSE (1-192): 3.81e-86: 253: 100.00		IQGA1_MOUSE (7-1631): 0: 1543: 58.85
+	Hs
		925259 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		IQGA2_HUMAN (86-1631): 0: 1356: 42.50
+	Hs
		564517 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		IQGA2_HUMAN (86-1631): 0: 1356: 42.50
+	Hs
		925282 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		RASA3_HUMAN (841-1504): 2.12e-105: 359: 13.68
+	Hs
		545380 RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19		RASA3_HUMAN (841-1504): 2.12e-105: 359: 13.68
+	Hs
		925728 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		MYO5B_HUMAN (696-1522): 2.83e-96: 346: 14.42
+	Hs
		564757 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		MYO5A_HUMAN (685-1556): 7.11e-89: 323: 14.90
+	Hs
		925715 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		NGAP_HUMAN (1000-1453): 5.22e-81: 294: 17.18
+	Hs
		564728 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		NGAP_HUMAN (1000-1453): 5.22e-81: 294: 17.18
+	Hs
		545691 RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19		NGAP_HUMAN (1000-1453): 5.22e-81: 294: 17.18
+	Gg
		1141019 Q6LC82_CHICK (1-192): 3.81e-86: 253: 100.00		ARHG6_CHICK (37-448): 7.38e-77: 274: 11.83
+	Hs
		925347 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		DAB2P_HUMAN (1000-1424): 2.56e-68: 255: 15.03
+	Hs
		925530 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		SYGP1_HUMAN (1000-1345): 1.08e-65: 247: 16.44
+	Hs
		545434 RAC2_HUMAN (1-192): 1.2e-82: 244: 92.19		DAB2P_HUMAN (1000-1424): 2.56e-68: 255: 15.03
+	Hs
		598457 RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00		NF1_HUMAN (967-1301): 9.74e-45: 181: 21.57
+	Hs
		564412 RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67		NF1_HUMAN (967-1301): 9.74e-45: 181: 21.57