HitPredict

Interactor 1: E9PMD8 (E9PMD8)
Proteasome 26S subunit, ATPase 3
Gene: PSMC3

Interactor 2: PSMD4 (P55036)
26S proteasome non-ATPase regulatory subunit 4 (26S proteasome regulatory subunit RPN10) (26S proteasome regulatory subunit S5A) (Antisecretory factor 1) (AF) (ASF) (Multiubiquitin chain-binding protein)
Gene: PSMD4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	35271311
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0008540 - proteasome regulatory particle, base subcomplex GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 301 Hs			1 377
+	Hs
		572908 PRS6A_HUMAN (20-301): 6.23e-77: 242: 95.47		PSMD4_HUMAN (1-364): 0: 530: 100.00
+	Hs
		572991 PRS6A_HUMAN (20-301): 6.23e-77: 242: 95.47		Q5VWC4_HUMAN (1-364): 0: 525: 99.18
+	Hs
		730226 PRS7_HUMAN (14-300): 2.33e-68: 220: 31.71		PSMD4_HUMAN (1-364): 0: 530: 100.00
+	Hs
		798622 PRS6B_HUMAN (9-301): 2.8e-68: 220: 34.13		PSMD4_HUMAN (1-364): 0: 530: 100.00
+	Hs
		56606 PRS4_HUMAN (18-301): 6.7e-67: 217: 36.81		PIPSL_HUMAN (3-364): 0: 532: 92.54
+	Hs
		874063 PRS4_HUMAN (18-301): 6.7e-67: 217: 36.81		PSMD4_HUMAN (1-364): 0: 530: 100.00
+	Hs
		798692 PRS6B_HUMAN (9-301): 2.8e-68: 220: 34.13		Q5VWC4_HUMAN (1-364): 0: 525: 99.18
+	Xl
		804063 PRS8_XENLA (57-301): 8.32e-70: 225: 37.40		Q4V845_XENLA (1-364): 0: 519: 91.48
+	Hs
		906854 PRS4_HUMAN (18-301): 6.7e-67: 217: 36.81		Q5VWC4_HUMAN (1-364): 0: 525: 99.18
+	Dm
		820472 PRS4_DROME (51-301): 1.04e-87: 270: 40.00		PSMD4_DROME (1-359): 6.74e-149: 428: 57.40
+	Hs
		874050 TERA_HUMAN (4-301): 6.57e-45: 164: 23.64		PSMD4_HUMAN (1-364): 0: 530: 100.00
+	Ce
		247733 PRS6B_CAEEL (45-301): 5.6e-86: 265: 36.58		PSMD4_CAEEL (1-372): 6.25e-116: 342: 44.97
+	Sp
		293403 PRS4_SCHPO (51-301): 4.94e-85: 264: 38.04		RPN10_SCHPO (1-245): 5.11e-104: 308: 45.75
+	At
		874025 PRS4A_ARATH (61-301): 2.11e-49: 171: 39.00		PSMD4_ARATH (1-377): 4.15e-138: 400: 41.32
+	Sp
		144486 PRS6A_SCHPO (31-301): 7.89e-73: 232: 70.22		RPN10_SCHPO (1-245): 5.11e-104: 308: 45.75
+	Sc
		703797 PRS6B_YEAST (13-301): 5.65e-71: 227: 32.19		RPN10_YEAST (1-224): 1.27e-98: 295: 49.15
+	Sc
		703615 PRS6A_YEAST (24-301): 1.52e-69: 223: 65.85		RPN10_YEAST (1-224): 1.27e-98: 295: 49.15
+	Sc
		756944 PRS4_YEAST (129-301): 4.7e-51: 175: 50.29		RPN10_YEAST (1-224): 1.27e-98: 295: 49.15
+	Sc
		636619 CDC48_YEAST (23-301): 3.1e-46: 168: 24.42		RPN10_YEAST (1-224): 1.27e-98: 295: 49.15