HitPredict

Interactor 1: E9PMD8 (E9PMD8)
Proteasome 26S subunit, ATPase 3
Gene: PSMC3

Interactor 2: PSMD1 (Q99460)
26S proteasome non-ATPase regulatory subunit 1 (26S proteasome regulatory subunit RPN2) (26S proteasome regulatory subunit S1) (26S proteasome subunit p112)
Gene: PSMD1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	35271311
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0008540 - proteasome regulatory particle, base subcomplex GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 301 Hs			1 953
+	Hs
		573054 PRS6A_HUMAN (20-301): 6.23e-77: 242: 95.47		PSMD1_HUMAN (1-953): 0: 1310: 100.00
+	Hs
		683 PRS6A_HUMAN (20-301): 6.23e-77: 242: 95.47		A0A087WW66_HUMAN (1-953): 0: 1204: 93.10
+	Dm
		820502 PRS4_DROME (51-301): 1.04e-87: 270: 40.00		PSMD1_DROME (2-933): 0: 1114: 61.64
+	Dm
		1181026 Q7KMQ0_DROME (14-300): 2.08e-78: 246: 31.36		PSMD1_DROME (2-933): 0: 1114: 61.64
+	Dm
		1358999 Q9V3V6_DROME (34-301): 1.89e-71: 228: 85.82		PSMD1_DROME (2-933): 0: 1114: 61.64
+	Sp
		251844 PRS4_SCHPO (51-301): 4.94e-85: 264: 38.04		RPN2_SCHPO (1-953): 0: 1042: 43.67
+	Sp
		251840 PRS6B_SCHPO (43-301): 3.46e-71: 226: 33.21		RPN2_SCHPO (1-953): 0: 1042: 43.67
+	Sc
		693270 PRS6B_YEAST (13-301): 5.65e-71: 227: 32.19		RPN2_YEAST (2-953): 0: 984: 40.26
+	Sc
		693269 PRS6A_YEAST (24-301): 1.52e-69: 223: 65.85		RPN2_YEAST (2-953): 0: 984: 40.26
+	Hs
		92620 E9PMD8_HUMAN (1-301): 1.14e-82: 253: 100.00		PSMD2_HUMAN (8-796): 0: 802: 18.73
+	Hs
		572941 PRS6A_HUMAN (20-301): 6.23e-77: 242: 95.47		PSMD2_HUMAN (8-796): 0: 802: 18.73
+	Dm
		820527 PRS4_DROME (51-301): 1.04e-87: 270: 40.00		Q9VW54_DROME (12-796): 0: 702: 16.86
+	At
		1352071 PS6AA_ARATH (37-301): 8.82e-71: 226: 76.69		PSD2A_ARATH (8-796): 0: 738: 17.61
+	At
		1319802 PRS8A_ARATH (35-300): 2.49e-70: 225: 35.58		PSD2A_ARATH (8-796): 0: 738: 17.61
+	Dm
		1181057 Q7KMQ0_DROME (14-300): 2.08e-78: 246: 31.36		Q9VW54_DROME (12-796): 0: 702: 16.86
+	Dm
		1359237 Q9V3V6_DROME (34-301): 1.89e-71: 228: 85.82		Q9VW54_DROME (12-796): 0: 702: 16.86
+	Sp
		736965 PRS4_SCHPO (51-301): 4.94e-85: 264: 38.04		RPN1_SCHPO (8-794): 0: 666: 18.03
+	Sp
		252272 PRS6B_SCHPO (43-301): 3.46e-71: 226: 33.21		RPN1_SCHPO (8-794): 0: 666: 18.03
+	Sc
		703796 PRS6B_YEAST (13-301): 5.65e-71: 227: 32.19		RPN1_YEAST (8-604): 4.59e-149: 468: 15.96
+	Sc
		703610 PRS6A_YEAST (24-301): 1.52e-69: 223: 65.85		RPN1_YEAST (8-604): 4.59e-149: 468: 15.96