Protein: PDE4D
3',5'-cyclic-AMP phosphodiesterase 4D (EC 3.1.4.53) (DPDE3) (PDE43) (cAMP-specific phosphodiesterase 4D)

Gene: PDE4D
Organism: Homo sapiens
Interactions: 65
UniProt ID: Q08499

Gene Ontology (top 5):
GO:0002027 - regulation of heart rate
GO:0004114 - 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004115 - 3',5'-cyclic-AMP phosphodiesterase activity
GO:0005246 - calcium channel regulator activity
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1059203

PDE4B
3',5'-cyclic-AMP phosphodiesterase 4B

2

8

High-throughput

0.802

High

992705

RACK1
Small ribosomal subunit protein RACK1

4

3

Small-scale

0.704

High

732559

ARRB2
Beta-arrestin-2

4

4

Small-scale

0.698

High

698209

PDE4A
3',5'-cyclic-AMP phosphodiesterase 4A

1

7

High-throughput

0.691

High

1064373

PDE4D
3',5'-cyclic-AMP phosphodiesterase 4D

1

8

Small-scale

0.647

High

605652

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

3

10

Small-scale

0.646

High

799863

COIL
Coilin

3

0

High-throughput

0.646

High

882464

ARRB1
Beta-arrestin-1

2

4

Small-scale

0.586

High

1064376

TRAF1
TNF receptor-associated factor 1

1

1

High-throughput

0.573

High

845292

LIS1
Platelet-activating factor acetylhydrolase IB subunit beta

1

3

Small-scale

0.561

High

919911

PLK1
Serine/threonine-protein kinase PLK1

2

0

High-throughput

0.559

High

1064381

ITSN1
Intersectin-1

1

2

High-throughput

0.552

High

1064382

MYOME
Myomegalin

1

1

Small-scale

0.552

High

1028167

MDM2
E3 ubiquitin-protein ligase Mdm2

1

0

Small-scale

0.537

High

463481

LYN
Tyrosine-protein kinase Lyn

1

6

Small-scale

0.536

High

257046

F262
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2

1

2

High-throughput

0.536

High

343583

OXSR1
Serine/threonine-protein kinase OSR1

1

4

High-throughput

0.536

High

582087

PGAM2
Phosphoglycerate mutase 2

1

2

High-throughput

0.536

High

1064378

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

6

High-throughput

0.536

High

1064386

ZDH17
Palmitoyltransferase ZDHHC17

1

1

High-throughput

0.532

High

848371

MAGA6
Melanoma-associated antigen 6

1

1

High-throughput

0.523

High

1064390

OPTN
Optineurin

1

2

High-throughput

0.515

High

1064394

ABCF3
ATP-binding cassette sub-family F member 3

1

0

High-throughput

0.513

High

362265

ABL1
Tyrosine-protein kinase ABL1

1

6

Small-scale

0.501

High

374549

RASH
GTPase HRas

1

1

Small-scale

0.501

High

421992

A4
Amyloid-beta precursor protein

1

3

High-throughput

0.501

High

440515

FYN
Tyrosine-protein kinase Fyn

1

6

Small-scale

0.501

High

557258

SRC
Proto-oncogene tyrosine-protein kinase Src

1

6

Small-scale

0.501

High

891491

GSK3B
Glycogen synthase kinase-3 beta

1

1

Small-scale

0.501

High

987585

GRB2
Growth factor receptor-bound protein 2

1

8

Small-scale

0.501

High

1064387

PIAS4
E3 SUMO-protein ligase PIAS4

1

1

Small-scale

0.501

High

1064399

FBX7
F-box only protein 7

1

1

High-throughput

0.501

High

1039936

AKA12
A-kinase anchor protein 12

1

0

Small-scale

0.493

High

1064393

RXFP1
Relaxin receptor 1

1

3

Small-scale

0.484

High

699718

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

0

Small-scale

0.480

High

703553

MK01
Mitogen-activated protein kinase 1

1

0

Small-scale

0.480

High

876837

KC1A
Casein kinase I isoform alpha

1

0

Small-scale

0.480

High

1064379

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

0

Small-scale

0.480

High

593837

PP2BB
Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform

1

3

Small-scale

0.479

High

699922

IP3KB
Inositol-trisphosphate 3-kinase B

1

1

High-throughput

0.479

High

989898

CANB1
Calcineurin subunit B type 1

1

1

Small-scale

0.479

High

1062359

PP2BA
Protein phosphatase 3 catalytic subunit alpha

1

3

Small-scale

0.479

High

1064375

AKAP6
A-kinase anchor protein 6

1

2

Small-scale

0.479

High

1064377

CUL1
Cullin-1

1

1

Small-scale

0.479

High

1064397

SHAN2
SH3 and multiple ankyrin repeat domains protein 2

1

3

Small-scale

0.479

High

783248

TRI23
E3 ubiquitin-protein ligase TRIM23

1

0

High-throughput

0.460

High

551009

PCNA
Proliferating cell nuclear antigen

1

0

High-throughput

0.458

High

667806

CDK2
Cyclin-dependent kinase 2

1

0

High-throughput

0.458

High

872253

SOX2
Transcription factor SOX-2

1

0

High-throughput

0.458

High

873909

INAR2
Interferon alpha/beta receptor 2

1

0

Small-scale

0.458

High

1064380

PAQRB
Monocyte to macrophage differentiation factor

1

0

Small-scale

0.458

High

1064388

TOPB1
DNA topoisomerase 2-binding protein 1

1

0

High-throughput

0.458

High

1064396

FBX2
F-box only protein 2

1

0

Small-scale

0.458

High

1064398

ZBTB1
Zinc finger and BTB domain-containing protein 1

1

0

Small-scale

0.458

High

641332

RYR1
Ryanodine receptor 1

1

5

Small-scale

0.445

High

1064383

A16L1
Autophagy-related protein 16-1

1

4

High-throughput

0.445

High

1064391

CF418
Cilia- and flagella-associated protein 418

1

0

Small-scale

0.438

High

1064385

LRC31
Leucine-rich repeat-containing protein 31

1

1

High-throughput

0.437

High

665888

AKAP5
A-kinase anchor protein 5

1

0

Small-scale

0.426

High

1064384

PDXD1
Pyridoxal-dependent decarboxylase domain-containing protein 1

1

0

High-throughput

0.279

Low

1064392

CLPB
Mitochondrial disaggregase

1

0

High-throughput

0.279

Low

1064374

GOG8D
Putative golgin subfamily A member 8D

1

0

High-throughput

0.268

Low

1064389

ATOH1
Transcription factor ATOH1

1

0

Small-scale

0.249

Low

1064395

DS13B
Dual specificity protein phosphatase 13B

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025