HitPredict

Interactor 1: 1433Z (P63104)
14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1)
Gene: YWHAZ

Interactor 2: KPCE (Q02156)
Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon)
Gene: PRKCE

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.84	1.00	0.919

Property	Details
Experiments	31980649, 11950841, 12893243, unassigned2173, 19662078
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation, molecular sieving, isothermal titration calorimetry, x-ray crystallography
Interaction Type	physical association, association, direct interaction

Property	Details
Interacting Pfam domains	14-3-3~C1_1
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0006468 - protein phosphorylation GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 245 Hs			1 737
+	Hs
		909458 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		KPCE_HUMAN (1-737): 0: 889: 100.00
+	Hs
		646812 1433T_HUMAN (1-245): 2.6e-140: 395: 79.59		KPCE_HUMAN (1-737): 0: 889: 100.00
+	Hs
		683276 1433B_HUMAN (1-242): 9.01e-140: 393: 87.60		KPCE_HUMAN (1-737): 0: 889: 100.00
+	Mm
		554936 1433B_MOUSE (1-242): 3.77e-128: 364: 87.19		KPCE_MOUSE (1-737): 0: 889: 97.97
+	Hs
		646820 1433T_HUMAN (1-245): 2.6e-140: 395: 79.59		KPCT_HUMAN (34-733): 0: 728: 40.99
+	Hs
		926957 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		KPCD_HUMAN (31-735): 0: 711: 39.55
+	Hs
		683287 1433B_HUMAN (1-242): 9.01e-140: 393: 87.60		KPCD_HUMAN (31-735): 0: 711: 39.55
+	Hs
		566348 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		KPCA_HUMAN (137-736): 0: 613: 44.58
+	Hs
		566293 1433T_HUMAN (1-245): 2.6e-140: 395: 79.59		KPCA_HUMAN (137-736): 0: 613: 44.58
+	Hs
		397155 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		KPCG_HUMAN (156-736): 0: 573: 42.65
+	Hs
		397154 1433G_HUMAN (1-240): 2.37e-108: 314: 74.59		KPCG_HUMAN (156-736): 0: 573: 42.65
+	Hs
		681776 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		AKT1_HUMAN (370-732): 2.55e-153: 455: 45.26
+	Hs
		681770 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		AKT1_HUMAN (370-732): 2.55e-153: 455: 45.26
+	Hs
		783973 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		KPCI_HUMAN (91-240): 4.44e-33: 137: 26.49
+	Hs
		783970 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		KPCI_HUMAN (91-240): 4.44e-33: 137: 26.49
+	Hs
		926956 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		KPCZ_HUMAN (91-220): 3.08e-30: 128: 27.48
+	Hs
		646701 1433T_HUMAN (1-245): 2.6e-140: 395: 79.59		KPCI_HUMAN (91-240): 4.44e-33: 137: 26.49
+	Hs
		683182 1433B_HUMAN (1-242): 9.01e-140: 393: 87.60		KPCI_HUMAN (91-240): 4.44e-33: 137: 26.49
+	Hs
		646824 1433T_HUMAN (1-245): 2.6e-140: 395: 79.59		KPCZ_HUMAN (91-220): 3.08e-30: 128: 27.48
+	Hs
		683286 1433B_HUMAN (1-242): 9.01e-140: 393: 87.60		KPCZ_HUMAN (91-220): 3.08e-30: 128: 27.48