HitPredict

Interactor 1: E9PQQ4 (E9PQQ4)
Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8)
Gene: HSPA8

Interactor 2: HSP74 (P34932)
Heat shock 70 kDa protein 4 (HSP70RY) (Heat shock 70-related protein APG-2) (Heat shock protein family H member 2)
Gene: HSPA4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	35271311
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	HSP70~HSP70
Common GO terms	GO:0005524 - ATP binding GO:0140662 - ATP-dependent protein folding chaperone
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 171 Hs			1 840
+	Hs
		503544 HSP7C_HUMAN (1-171): 4.49e-104: 313: 100.00		HSP74_HUMAN (1-840): 0: 993: 100.00
+	Hs
		483777 HS71B_HUMAN (1-171): 5.2e-102: 307: 87.72		HSP74_HUMAN (1-840): 0: 993: 100.00
+	Hs
		713910 HS71L_HUMAN (2-171): 5.25e-101: 305: 84.71		HSP74_HUMAN (1-840): 0: 993: 100.00
+	Hs
		714156 HSP72_HUMAN (2-171): 7.21e-101: 304: 87.65		HSP74_HUMAN (1-840): 0: 993: 100.00
+	Hs
		320802 HSP7C_HUMAN (1-171): 4.49e-104: 313: 100.00		HS74L_HUMAN (1-840): 0: 959: 63.21
+	Hs
		320833 HSP72_HUMAN (2-171): 7.21e-101: 304: 87.65		HS74L_HUMAN (1-840): 0: 959: 63.21
+	Hs
		504490 HSP7C_HUMAN (1-171): 4.49e-104: 313: 100.00		HS105_HUMAN (1-840): 0: 938: 62.95
+	Hs
		92702 E9PQQ4_HUMAN (1-171): 1.1e-108: 308: 100.00		HS105_HUMAN (1-840): 0: 938: 62.95
+	Hs
		1120566 Q53FA3_HUMAN (2-171): 4.77e-101: 305: 84.71		HS105_HUMAN (1-840): 0: 938: 62.95
+	Hs
		714034 HS71L_HUMAN (2-171): 5.25e-101: 305: 84.71		HS105_HUMAN (1-840): 0: 938: 62.95
+	Hs
		503315 HSP7C_HUMAN (1-171): 4.49e-104: 313: 100.00		HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92
+	Mm
		926115 HSP7C_MOUSE (1-171): 4.21e-104: 313: 100.00		HSP7C_MOUSE (564-692): 1.76e-19: 95.5: 16.15
+	Hs
		503543 HSP7C_HUMAN (1-171): 4.49e-104: 313: 100.00		HS71L_HUMAN (564-691): 7.22e-19: 93.5: 22.48
+	Hs
		503752 HSP72_HUMAN (2-171): 7.21e-101: 304: 87.65		HSP7C_HUMAN (564-692): 5.97e-20: 97: 16.92
+	Hs
		503389 HSP7C_HUMAN (1-171): 4.49e-104: 313: 100.00		HSP76_HUMAN (587-690): 1.94e-16: 85.8: 22.86
+	Mm
		571859 HS71A_MOUSE (1-171): 5.14e-101: 305: 87.72		HS71B_MOUSE (571-686): 9.97e-18: 89.7: 23.08
+	Hs
		564046 HSP72_HUMAN (2-171): 7.21e-101: 304: 87.65		HSP76_HUMAN (587-690): 1.94e-16: 85.8: 22.86
+	Hs
		871593 HSP72_HUMAN (2-171): 7.21e-101: 304: 87.65		Q53FC7_HUMAN (587-690): 3.01e-16: 85.1: 22.86