HitPredict

Interactor 1: 1433Z (P63104)
14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1)
Gene: YWHAZ

Interactor 2: WWC2 (Q6AWC2)
Protein WWC2 (BH-3-only member B) (WW domain-containing protein 2)
Gene: WWC2

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.656

Property	Details
Experiments	35271311, 36931259, 15161933
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 245 Hs			1 1192
+	Hs
		909674 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		WWC2_HUMAN (1-1192): 0: 1008: 100.00
+	Hs
		927277 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		KIBRA_HUMAN (1-1192): 0: 810: 49.04
+	Hs
		909790 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		KIBRA_HUMAN (1-1192): 0: 810: 49.04
+	Hs
		927592 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		WWOX_HUMAN (5-198): 5.51e-47: 176: 21.11
+	Hs
		125351 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		WWP2_HUMAN (3-143): 4.17e-30: 131: 23.84
+	Hs
		125318 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		WWP2_HUMAN (3-143): 4.17e-30: 131: 23.84
+	Hs
		125169 1433T_HUMAN (1-245): 2.6e-140: 395: 79.59		WWP2_HUMAN (3-143): 4.17e-30: 131: 23.84
+	Hs
		927520 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		SAV1_HUMAN (4-88): 3.52e-27: 117: 38.82
+	Hs
		910022 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		SAV1_HUMAN (4-88): 3.52e-27: 117: 38.82
+	Mm
		808343 1433E_MOUSE (2-241): 9.9e-144: 403: 68.18		NEDD4_MOUSE (54-164): 5.95e-20: 98.5: 19.30
+	Mm
		910341 1433E_MOUSE (2-241): 9.9e-144: 403: 68.18		RIMS2_MOUSE (556-832): 3.94e-13: 76.6: 13.78
+	Hs
		808081 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		NEDD4_HUMAN (1-173): 9.35e-12: 71.9: 15.64
+	Hs
		808077 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		NEDD4_HUMAN (1-173): 9.35e-12: 71.9: 15.64
+	Hs
		808489 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		YAP1_HUMAN (41-163): 9.64e-10: 64.5: 18.25
+	Rn
		910358 1433E_RAT (2-241): 9.9e-144: 403: 68.18		NEDD4_RAT (1-241): 4.08e-10: 66.5: 15.32
+	Hs
		808460 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		YAP1_HUMAN (41-163): 9.64e-10: 64.5: 18.25
+	Hs
		927423 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		NED4L_HUMAN (1-141): 6.93e-09: 62.3: 18.37
+	Hs
		909930 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		NED4L_HUMAN (1-141): 6.93e-09: 62.3: 18.37
+	Mm
		910302 1433E_MOUSE (2-241): 9.9e-144: 403: 68.18		NED4L_MOUSE (1-141): 7.95e-09: 62.3: 17.01
+	Mm
		93264 1433E_MOUSE (2-241): 9.9e-144: 403: 68.18		E9PXB7_MOUSE (1-141): 7.04e-09: 62.3: 17.01