Protein: LHX6
LIM/homeobox protein Lhx6 (LIM homeobox protein 6) (LIM/homeobox protein Lhx6.1)

Gene: LHX6
Organism: Homo sapiens
Interactions: 67
UniProt ID: Q9UPM6

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0003700 - DNA-binding transcription factor activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1287938

LDB1
LIM domain-binding protein 1

7

20

High-throughput

0.971

High

1462468

SATB2
DNA-binding protein SATB2

3

7

High-throughput

0.861

High

1246450

FIGLA
Factor in the germline alpha

2

14

High-throughput

0.783

High

1010792

SSBP2
Single-stranded DNA-binding protein 2

4

20

High-throughput

0.699

High

1416161

SSBP4
Single-stranded DNA-binding protein 4

4

20

High-throughput

0.699

High

1416433

SSBP3
Single-stranded DNA-binding protein 3

4

20

High-throughput

0.699

High

253030

LMX1B
LIM homeobox transcription factor 1-beta

1

19

High-throughput

0.691

High

833795

KDM5C
Lysine-specific demethylase 5C

3

7

High-throughput

0.667

High

1180200

QRIC1
Transcriptional regulator QRICH1

3

17

High-throughput

0.667

High

1214984

RN187
E3 ubiquitin-protein ligase RNF187

3

4

High-throughput

0.667

High

1288395

TLK2
Serine/threonine-protein kinase tousled-like 2

3

7

High-throughput

0.667

High

1309382

ARI3B
AT-rich interactive domain-containing protein 3B

3

20

High-throughput

0.667

High

1349889

ZN507
Zinc finger protein 507

3

7

High-throughput

0.667

High

1411589

NUD22
Uridine diphosphate glucose pyrophosphatase NUDT22

3

1

High-throughput

0.667

High

1462469

CARD8
Caspase recruitment domain-containing protein 8

3

1

High-throughput

0.667

High

1204642

BCORL
BCL-6 corepressor-like protein 1

1

4

High-throughput

0.618

High

1229379

LHX8
LIM/homeobox protein Lhx8

1

17

High-throughput

0.618

High

1396327

EHMT2
Histone-lysine N-methyltransferase EHMT2

1

17

High-throughput

0.618

High

1462467

TRI33
E3 ubiquitin-protein ligase TRIM33

2

10

High-throughput

0.611

High

1462471

SALL2
Sal-like protein 2

2

3

High-throughput

0.611

High

1462472

WIPI4
WD repeat domain phosphoinositide-interacting protein 4

3

2

High-throughput

0.609

High

783767

ZNF76
Zinc finger protein 76

2

7

High-throughput

0.606

High

913856

ZN138
Zinc finger protein 138

2

3

High-throughput

0.606

High

944766

KLF3
Krueppel-like factor 3

2

10

High-throughput

0.606

High

1034379

ROR2
Tyrosine-protein kinase transmembrane receptor ROR2

2

15

High-throughput

0.606

High

1161000

NRF1
Nuclear respiratory factor 1

2

3

High-throughput

0.606

High

1407525

CPNE1
Copine-1

2

1

High-throughput

0.606

High

1032440

OTUD4
OTU domain-containing protein 4

2

0

High-throughput

0.585

High

1118836

TF2H2
General transcription factor IIH subunit 2

2

0

High-throughput

0.585

High

415938

HSPB1
Heat shock protein beta-1

1

3

High-throughput

0.515

High

791842

SYUA
Alpha-synuclein

1

2

High-throughput

0.515

High

844101

HD
Huntingtin

1

3

High-throughput

0.515

High

927176

ATX3
Ataxin-3

1

1

High-throughput

0.515

High

927612

ATX1
Ataxin-1

1

6

High-throughput

0.515

High

1462470

RNF11
RING finger protein 11

1

4

High-throughput

0.515

High

1010394

BASP1
Brain acid soluble protein 1

1

2

High-throughput

0.500

High

177482

ZN536
Zinc finger protein 536

1

5

High-throughput

0.479

High

505626

ATX1L
Ataxin-1-like

1

6

High-throughput

0.479

High

586356

ZEP1
Zinc finger protein 40

1

17

High-throughput

0.479

High

790110

ZEB1
Zinc finger E-box-binding homeobox 1

1

8

High-throughput

0.479

High

926434

BLM
RecQ-like DNA helicase BLM

1

3

High-throughput

0.479

High

1048135

TLE3
Transducin-like enhancer protein 3

1

11

High-throughput

0.479

High

1228293

ARID2
AT-rich interactive domain-containing protein 2

1

20

High-throughput

0.479

High

1257171

PAXI1
PAX-interacting protein 1

1

13

High-throughput

0.479

High

1288012

PB1
Protein polybromo-1

1

15

High-throughput

0.479

High

1289058

BCL9L
B-cell CLL/lymphoma 9-like protein

1

20

High-throughput

0.479

High

1309845

WDFY1
WD repeat and FYVE domain-containing protein 1

1

4

High-throughput

0.479

High

1340172

KDM2B
Lysine-specific demethylase 2B

1

5

High-throughput

0.479

High

1356519

PHF10
PHD finger protein 10

1

20

High-throughput

0.479

High

1365824

ZN516
Zinc finger protein 516

1

6

High-throughput

0.479

High

1385316

ZBTB9
Zinc finger and BTB domain-containing protein 9

1

6

High-throughput

0.479

High

1401453

CIC
Protein capicua homolog

1

20

High-throughput

0.479

High

1446439

BRD7
Bromodomain-containing protein 7

1

7

High-throughput

0.479

High

1462473

ZSC21
Zinc finger and SCAN domain-containing protein 21

1

7

High-throughput

0.479

High

47433

A0A6Q8PF08
Peripheral myelin protein 22

1

1

High-throughput

0.470

High

301763

WFS1
Wolframin

1

1

High-throughput

0.470

High

369782

A2MG
Alpha-2-macroglobulin

1

1

High-throughput

0.470

High

705609

GRN
Progranulin

1

1

High-throughput

0.470

High

1401785

MCCA
Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial

1

0

High-throughput

0.458

High

889041

TMEDA
Transmembrane emp24 domain-containing protein 10

1

4

High-throughput

0.457

High

1063896

LG3BP
Galectin-3-binding protein

1

2

High-throughput

0.457

High

1415431

TMED9
Transmembrane emp24 domain-containing protein 9

1

3

High-throughput

0.457

High

139032

BCL9
B-cell CLL/lymphoma 9 protein

1

20

High-throughput

0.437

High

1385178

ATG2B
Autophagy-related protein 2 homolog B

3

0

High-throughput

0.347

High

1295132

F90A1
Protein FAM90A1

2

0

High-throughput

0.316

High

165784

PAHX
Phytanoyl-CoA dioxygenase, peroxisomal

1

0

High-throughput

0.268

Low

425977

PCCB
Propionyl-CoA carboxylase beta chain, mitochondrial

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025