HitPredict

Interactor 1: 1433Z (P63104)
14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1)
Gene: YWHAZ

Interactor 2: CSN5 (Q92905)
COP9 signalosome complex subunit 5 (SGN5) (Signalosome subunit 5) (EC 3.4.-.-) (Jun activation domain-binding protein 1)
Gene: COPS5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.614

Property	Details
Experiments	20936779, 21145461
Identification Methods	two hybrid, affinity chromatography technology, tandem affinity purification
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0043066 - negative regulation of apoptotic process
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 245 Hs			1 334
+	At
		788616 14333_ARATH (3-239): 1.48e-141: 398: 64.73		CSN5B_ARATH (1-334): 8.46e-119: 348: 66.57
+	Hs
		904948 1433G_HUMAN (1-240): 2.37e-108: 314: 74.59		CSN5_HUMAN (1-334): 6.64e-131: 378: 100.00
+	Hs
		684250 1433S_HUMAN (1-237): 8.27e-104: 302: 71.97		CSN5_HUMAN (1-334): 6.64e-131: 378: 100.00
+	Hs
		130840 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		PSDE_HUMAN (50-331): 1.67e-79: 246: 31.51
+	Hs
		124823 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		EIF3F_HUMAN (44-328): 3.25e-64: 208: 14.48
+	Hs
		849187 1433F_HUMAN (2-240): 1.26e-107: 312: 74.49		PSMD7_HUMAN (52-325): 1.07e-66: 214: 14.79
+	Hs
		176955 1433S_HUMAN (1-237): 8.27e-104: 302: 71.97		EIF3H_HUMAN (52-320): 2.17e-66: 214: 18.57
+	Hs
		805518 1433G_HUMAN (1-240): 2.37e-108: 314: 74.59		BRCC3_HUMAN (56-203): 4.61e-43: 152: 21.23
+	Hs
		805523 1433F_HUMAN (2-240): 1.26e-107: 312: 74.49		BRCC3_HUMAN (56-203): 4.61e-43: 152: 21.23