Protein: UB2E3
Ubiquitin-conjugating enzyme E2 E3 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme E3) (UbcH9) (Ubiquitin carrier protein E3) (Ubiquitin-conjugating enzyme E2-23 kDa) (Ubiquitin-protein ligase E3)

Gene: UB2E3, UBE2E3
Organism: Homo sapiens
Interactions: 148
UniProt ID: Q969T4

Gene Ontology (top 5):
GO:0004842 - ubiquitin-protein transferase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1381178

RNF25
E3 ubiquitin-protein ligase RNF25

7

14

Small-scale

0.970

High

1381191

RNF5
E3 ubiquitin-protein ligase RNF5

7

20

Small-scale

0.965

High

1381181

OTUB1
Ubiquitin thioesterase OTUB1

7

11

Small-scale

0.961

High

186570

TRI18
E3 ubiquitin-protein ligase Midline-1

6

20

Small-scale

0.951

High

799371

BRCA1
Breast cancer type 1 susceptibility protein

4

20

Small-scale

0.901

High

1381173

UB2E3
Ubiquitin-conjugating enzyme E2 E3

4

17

Small-scale

0.888

High

647619

UBA1
Ubiquitin-like modifier-activating enzyme 1

4

19

Small-scale

0.885

High

1328511

RNF10
E3 ubiquitin-protein ligase RNF10

3

20

High-throughput

0.875

High

1252762

RN111
E3 ubiquitin-protein ligase Arkadia

3

20

High-throughput

0.867

High

1381201

RN167
E3 ubiquitin-protein ligase RNF167

3

20

Small-scale

0.867

High

1381180

CHFR
E3 ubiquitin-protein ligase CHFR

3

20

High-throughput

0.861

High

1381188

RING2
E3 ubiquitin-protein ligase RING2

3

20

High-throughput

0.861

High

1381223

RN115
E3 ubiquitin-protein ligase RNF115

3

20

High-throughput

0.861

High

1217711

RN220
E3 ubiquitin-protein ligase RNF220

3

7

High-throughput

0.858

High

1381175

MUL1
Mitochondrial ubiquitin ligase activator of NFKB 1

3

20

Small-scale

0.852

High

132213

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

3

20

Small-scale

0.849

High

340584

CNOT4
CCR4-NOT transcription complex subunit 4

3

11

Small-scale

0.847

High

1028329

MDM2
E3 ubiquitin-protein ligase Mdm2

3

13

Small-scale

0.845

High

1381187

NED4L
E3 ubiquitin-protein ligase NEDD4-like

3

20

Small-scale

0.845

High

1381220

CHIP
E3 ubiquitin-protein ligase CHIP

3

15

Small-scale

0.845

High

1294323

TRI50
E3 ubiquitin-protein ligase TRIM50

3

20

Small-scale

0.845

High

1381183

RN185
E3 ubiquitin-protein ligase RNF185

5

20

High-throughput

0.834

High

1381214

RNF14
E3 ubiquitin-protein ligase RNF14

2

20

Small-scale

0.812

High

507301

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

2

20

High-throughput

0.811

High

1185935

PCGF3
Polycomb group RING finger protein 3

2

20

High-throughput

0.811

High

1381207

TOPRS
E3 ubiquitin-protein ligase Topors

2

6

High-throughput

0.811

High

1381221

RNF11
RING finger protein 11

2

20

High-throughput

0.811

High

1004933

RNF4
E3 ubiquitin-protein ligase RNF4

2

20

Small-scale

0.800

High

508388

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

2

20

Small-scale

0.778

High

1380801

TRI63
E3 ubiquitin-protein ligase TRIM63

2

20

Small-scale

0.767

High

1381218

TRIM1
Probable E3 ubiquitin-protein ligase MID2

3

20

Small-scale

0.755

High

1381217

HERC5
E3 ISG15--protein ligase HERC5

2

20

Small-scale

0.743

High

1381205

TRI39
E3 ubiquitin-protein ligase TRIM39

5

20

High-throughput

0.722

High

651396

CBL
E3 ubiquitin-protein ligase CBL

1

12

Small-scale

0.713

High

220513

RNF13
E3 ubiquitin-protein ligase RNF13

1

20

High-throughput

0.698

High

335161

ARI2
E3 ubiquitin-protein ligase ARIH2

1

20

High-throughput

0.698

High

1055839

RING1
E3 ubiquitin-protein ligase RING1

1

20

High-throughput

0.698

High

1093678

MKRN3
E3 ubiquitin-protein ligase makorin-3

1

14

High-throughput

0.698

High

1229028

RNF43
E3 ubiquitin-protein ligase RNF43

1

20

High-throughput

0.698

High

1243711

RFWD3
E3 ubiquitin-protein ligase RFWD3

1

20

High-throughput

0.698

High

1254112

ARK2C
E3 ubiquitin-protein ligase ARK2C

1

20

High-throughput

0.698

High

1294227

GOLI
E3 ubiquitin-protein ligase RNF130

1

20

High-throughput

0.698

High

1294545

DZIP3
E3 ubiquitin-protein ligase DZIP3

1

20

High-throughput

0.698

High

1331904

DTX3
Probable E3 ubiquitin-protein ligase DTX3

1

20

High-throughput

0.698

High

1336239

ZNRF1
E3 ubiquitin-protein ligase ZNRF1

1

20

High-throughput

0.698

High

1350938

DTX3L
E3 ubiquitin-protein ligase DTX3L

1

20

High-throughput

0.698

High

1381182

RMD5B
E3 ubiquitin-protein transferase RMND5B

1

6

High-throughput

0.698

High

1381198

TRI55
Tripartite motif-containing protein 55

1

20

High-throughput

0.698

High

1381200

TRIM2
Tripartite motif-containing protein 2

1

20

High-throughput

0.698

High

1381212

RN181
E3 ubiquitin-protein ligase RNF181

1

20

High-throughput

0.698

High

1381224

RN114
E3 ubiquitin-protein ligase RNF114

1

20

High-throughput

0.698

High

1381197

TRI54
Tripartite motif-containing protein 54

2

20

Small-scale

0.687

High

302601

RNF8
E3 ubiquitin-protein ligase RNF8

1

20

Small-scale

0.680

High

1381216

IPO11
Importin-11

1

3

Small-scale

0.680

High

1272654

DET1
DET1 homolog

3

3

Small-scale

0.667

High

242512

PRKN
E3 ubiquitin-protein ligase parkin

1

20

Small-scale

0.647

High

854708

RAGP1
Ran GTPase-activating protein 1

1

2

Small-scale

0.647

High

923620

TTC3
E3 ubiquitin-protein ligase TTC3

1

19

Small-scale

0.647

High

983924

RBX1
E3 ubiquitin-protein ligase RBX1

1

20

Small-scale

0.647

High

1112645

CUL1
Cullin-1

1

16

Small-scale

0.647

High

1113924

CUL3
Cullin-3

1

16

Small-scale

0.647

High

1114986

CUL4A
Cullin-4A

1

16

Small-scale

0.647

High

1204538

HERC4
Probable E3 ubiquitin-protein ligase HERC4

1

20

Small-scale

0.647

High

1381179

RNF31
E3 ubiquitin-protein ligase RNF31

1

20

Small-scale

0.647

High

1381184

ITCH
E3 ubiquitin-protein ligase Itchy homolog

1

20

Small-scale

0.647

High

625543

CSK22
Casein kinase II subunit alpha'

2

4

High-throughput

0.628

High

1381222

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

2

2

High-throughput

0.628

High

1359342

ZNRF4
E3 ubiquitin-protein ligase ZNRF4

1

20

High-throughput

0.625

High

1381176

RN166
E3 ubiquitin-protein ligase RNF166

1

20

High-throughput

0.625

High

1381219

RN150
RING finger protein 150

1

20

High-throughput

0.625

High

1093392

TRI32
E3 ubiquitin-protein ligase TRIM32

1

20

Small-scale

0.621

High

1340065

ZNRF2
E3 ubiquitin-protein ligase ZNRF2

1

20

Small-scale

0.621

High

1381193

RN126
E3 ubiquitin-protein ligase RNF126

1

20

High-throughput

0.621

High

1381202

TRI45
E3 ubiquitin-protein ligase TRIM45

1

20

Small-scale

0.621

High

927472

ATX1
Ataxin-1

2

1

High-throughput

0.620

High

261432

TBL1X
F-box-like/WD repeat-containing protein TBL1X

1

5

Small-scale

0.618

High

1381199

TBL1R
F-box-like/WD repeat-containing protein TBL1XR1

1

5

Small-scale

0.618

High

1381211

DTL
Denticleless protein homolog

1

9

Small-scale

0.618

High

329160

RCBT2
RCC1 and BTB domain-containing protein 2

3

19

Small-scale

0.612

High

832494

ETV5
ETS translocation variant 5

2

2

High-throughput

0.611

High

1349748

FBX25
F-box only protein 25

2

1

High-throughput

0.611

High

1381192

FSD1
Fibronectin type III and SPRY domain-containing protein 1

2

20

High-throughput

0.611

High

1381186

RDH12
Retinol dehydrogenase 12

3

1

High-throughput

0.609

High

1139099

DAZP2
DAZ-associated protein 2

2

2

High-throughput

0.606

High

1381194

TRI62
E3 ubiquitin-protein ligase TRIM62

2

20

High-throughput

0.606

High

1381206

PICK1
PRKCA-binding protein

2

1

High-throughput

0.606

High

1381210

PGPI
Pyroglutamyl-peptidase 1

2

1

High-throughput

0.606

High

1381189

BARD1
BRCA1-associated RING domain protein 1

2

10

Small-scale

0.602

High

1381196

PECR
Peroxisomal trans-2-enoyl-CoA reductase

2

0

High-throughput

0.602

High

73732

B2RDW1
Ubiquitin-ribosomal protein eS31 fusion protein

1

20

High-throughput

0.590

High

325968

UBR5
E3 ubiquitin-protein ligase UBR5

1

20

High-throughput

0.590

High

1280390

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

20

High-throughput

0.590

High

1381174

WBP2
WW domain-binding protein 2

2

0

High-throughput

0.580

High

1339826

PJA1
E3 ubiquitin-protein ligase Praja-1

1

20

Small-scale

0.579

High

1156692

NF2L2
Nuclear factor erythroid 2-related factor 2

1

3

Small-scale

0.561

High

1379901

NKD2
Protein naked cuticle homolog 2

2

1

High-throughput

0.558

High

1381177

ARRD3
Arrestin domain-containing protein 3

2

7

High-throughput

0.553

High

1096146

TADBP
TAR DNA-binding protein 43

1

2

Small-scale

0.552

High

843840

HD
Huntingtin

1

1

High-throughput

0.541

High

1289215

CAPS2
Calcium-dependent secretion activator 2

1

6

High-throughput

0.541

High

1371585

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

6

High-throughput

0.536

High

1381190

ARI3A
AT-rich interactive domain-containing protein 3A

1

0

Small-scale

0.529

High

1217033

Q5U5U6
Epididymis secretory protein Li 50

1

20

High-throughput

0.528

High

1381215

SAE2
SUMO-activating enzyme subunit 2

1

19

Small-scale

0.516

High

246080

KIF1B
Kinesin-like protein KIF1B

1

1

High-throughput

0.515

High

415768

HSPB1
Heat shock protein beta-1

1

1

High-throughput

0.515

High

481353

HMGB1
High mobility group protein B1

1

1

Small-scale

0.508

High

227631

SPOP
Speckle-type POZ protein

1

6

Small-scale

0.501

High

1260611

ASXL2
Putative Polycomb group protein ASXL2

1

3

Small-scale

0.501

High

1336714

RCBT1
RCC1 and BTB domain-containing protein 1

1

19

Small-scale

0.501

High

1381209

MARH5
E3 ubiquitin-protein ligase MARCHF5

1

6

Small-scale

0.501

High

1381213

KLH42
Kelch-like protein 42

1

6

Small-scale

0.501

High

954568

PRPS1
Ribose-phosphate pyrophosphokinase 1

1

0

High-throughput

0.493

High

142694

TRI38
E3 ubiquitin-protein ligase TRIM38

1

20

Small-scale

0.481

High

323516

TRI37
E3 ubiquitin-protein ligase TRIM37

1

20

Small-scale

0.481

High

572110

TRI27
Zinc finger protein RFP

1

20

Small-scale

0.481

High

964546

UFM1
Ubiquitin-fold modifier 1

1

5

High-throughput

0.481

High

1307763

SIAH1
E3 ubiquitin-protein ligase SIAH1

1

20

Small-scale

0.481

High

1238455

ZN746
Zinc finger protein 746

1

0

Small-scale

0.480

High

221167

SPY2
Protein sprouty homolog 2

1

1

High-throughput

0.479

High

260272

BRD4
Bromodomain-containing protein 4

1

7

High-throughput

0.479

High

537659

HSP7C
Heat shock cognate 71 kDa protein

1

1

High-throughput

0.479

High

620510

NUCL
Nucleolin

1

2

High-throughput

0.479

High

861243

MAP1B
Microtubule-associated protein 1B

1

2

High-throughput

0.479

High

1045610

TF65
Transcription factor p65

1

7

High-throughput

0.479

High

1052848

DUSP2
Dual specificity protein phosphatase 2

1

1

Small-scale

0.479

High

1108001

SQSTM
Sequestosome-1

1

18

High-throughput

0.479

High

1157850

DDB1
DNA damage-binding protein 1

1

1

Small-scale

0.479

High

1381195

DDA1
DET1- and DDB1-associated protein 1

1

2

Small-scale

0.479

High

1381204

RC3H2
Roquin-2

1

7

Small-scale

0.457

High

319958

UFL1
E3 UFM1-protein ligase 1

1

5

High-throughput

0.457

High

344563

LSM8
U6 snRNA-associated Sm-like protein LSm8

1

1

High-throughput

0.457

High

996281

EF1A1
Elongation factor 1-alpha 1

1

1

High-throughput

0.457

High

1122130

UBP2L
Ubiquitin-associated protein 2-like

1

2

High-throughput

0.457

High

1381208

CUED1
CUE domain-containing protein 1

1

2

High-throughput

0.439

High

898756

RL14
Large ribosomal subunit protein eL14

1

0

High-throughput

0.438

High

961077

MGN
Protein mago nashi homolog

1

0

High-throughput

0.438

High

1352969

CE192
Centrosomal protein of 192 kDa

1

0

High-throughput

0.438

High

68026

A8CGI2
Ubiquitin C

1

3

High-throughput

0.417

High

1327832

ARRD1
Arrestin domain-containing protein 1

1

7

High-throughput

0.417

High

1256687

CC121
Coiled-coil domain-containing protein 121

2

0

High-throughput

0.318

High

1381185

MERB1
bMERB domain-containing protein 1

1

0

High-throughput

0.279

Low

1381203

FBRS
Probable fibrosin-1

1

0

High-throughput

0.279

Low

301607

WFS1
Wolframin

1

0

High-throughput

0.268

Low

389866

TTHY
Transthyretin

1

0

High-throughput

0.268

Low

1338553

A2012
Putative ankyrin repeat domain-containing protein 20A12 pseudogene

1

0

High-throughput

0.238

Low

1381225

AUP1
Lipid droplet-regulating VLDL assembly factor AUP1

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025