HitPredict

Interactor 1: 1433Z (P63104)
14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1)
Gene: YWHAZ

Interactor 2: ARHG2 (Q92974)
Rho guanine nucleotide exchange factor 2 (Guanine nucleotide exchange factor H1) (GEF-H1) (Microtubule-regulated Rho-GEF) (Proliferating cell nucleolar antigen p40)
Gene: ARHGEF2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.92	0.60	0.745

Property	Details
Experiments	33961781, 35271311, 36931259, 22072711, 14970201, 28514442, 15161933
Identification Methods	affinity chromatography technology, proximity labelling technology, coimmunoprecipitation, anti tag coimmunoprecipitation, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005925 - focal adhesion GO:0031982 - vesicle
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 245 Hs			1 986
+	Hs
		909883 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		ARHG2_HUMAN (1-986): 0: 736: 100.00
+	Mm
		926797 1433Z_MOUSE (1-245): 3.48e-145: 407: 99.59		ARHG2_MOUSE (1-986): 0: 716: 88.55
+	Hs
		926978 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		AKP13_HUMAN (37-964): 2.77e-144: 478: 35.95
+	Hs
		909491 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		AKP13_HUMAN (37-964): 2.77e-144: 478: 35.95
+	Mm
		926776 1433Z_MOUSE (1-245): 3.48e-145: 407: 99.59		ARG28_MOUSE (11-876): 1.46e-135: 448: 35.73
+	Mm
		910228 1433E_MOUSE (2-241): 9.9e-144: 403: 68.18		ARG28_MOUSE (11-876): 1.46e-135: 448: 35.73
+	Hs
		927294 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		ARG28_HUMAN (11-875): 8.11e-130: 432: 35.80
+	Hs
		909803 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		ARG28_HUMAN (11-875): 8.11e-130: 432: 35.80
+	Mm
		926817 1433Z_MOUSE (1-245): 3.48e-145: 407: 99.59		ARHGI_MOUSE (1-982): 5.64e-125: 414: 28.54
+	Hs
		927198 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		ARHGI_HUMAN (1-982): 5.42e-125: 414: 30.77
+	Hs
		927416 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		SPT13_HUMAN (22-648): 3.96e-103: 338: 11.95
+	Hs
		909551 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		ARHG7_HUMAN (22-779): 1.98e-100: 335: 11.77
+	Mm
		926851 1433Z_MOUSE (1-245): 3.48e-145: 407: 99.59		ARHG6_MOUSE (15-797): 3.96e-98: 328: 11.14
+	Mm
		926883 1433Z_MOUSE (1-245): 3.48e-145: 407: 99.59		ARHG7_MOUSE (22-851): 9.73e-95: 321: 12.00
+	Mm
		926773 1433Z_MOUSE (1-245): 3.48e-145: 407: 99.59		RGRF2_MOUSE (44-801): 1.81e-89: 312: 12.66
+	Hs
		926988 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		TIAM1_HUMAN (14-814): 3.23e-87: 309: 16.14
+	Hs
		909501 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		TIAM1_HUMAN (14-814): 3.23e-87: 309: 16.14
+	Hs
		927568 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		ARHG4_HUMAN (72-648): 7.86e-86: 292: 12.85
+	Hs
		927148 1433Z_HUMAN (1-245): 1.67e-144: 405: 100.00		ARHGG_HUMAN (111-623): 6.11e-82: 282: 18.06
+	Hs
		909662 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		ARHGG_HUMAN (111-623): 6.11e-82: 282: 18.06