HitPredict

Interactor 1: 1433Z (P63104)
14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1)
Gene: YWHAZ

Interactor 2: SIN1 (Q9BPZ7)
Target of rapamycin complex 2 subunit MAPKAP1 (TORC2 subunit MAPKAP1) (Mitogen-activated protein kinase 2-associated protein 1) (Stress-activated map kinase-interacting protein 1) (SAPK-interacting protein 1) (mSIN1)
Gene: MAPKAP1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	35271311, 36931259
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0019901 - protein kinase binding GO:0043066 - negative regulation of apoptotic process
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 245 Hs			1 522
+	Hs
		909962 1433E_HUMAN (2-241): 9.9e-144: 403: 68.18		SIN1_HUMAN (1-522): 0: 894: 100.00
+	Hs
		647226 1433T_HUMAN (1-245): 2.6e-140: 395: 79.59		SIN1_HUMAN (1-522): 0: 894: 100.00
+	Hs
		683668 1433B_HUMAN (1-242): 9.01e-140: 393: 87.60		SIN1_HUMAN (1-522): 0: 894: 100.00
+	Hs
		905046 1433G_HUMAN (1-240): 2.37e-108: 314: 74.59		SIN1_HUMAN (1-522): 0: 894: 100.00
+	Hs
		982433 1433F_HUMAN (2-240): 1.26e-107: 312: 74.49		SIN1_HUMAN (1-522): 0: 894: 100.00
+	Hs
		684295 1433S_HUMAN (1-237): 8.27e-104: 302: 71.97		SIN1_HUMAN (1-522): 0: 894: 100.00
+	Dm
		955016 1433E_DROME (2-242): 3.33e-143: 402: 66.67		SIN1_DROME (1-508): 0: 522: 25.04