HitPredict

Interactor 1: SUMO1 (P63165)
Small ubiquitin-related modifier 1 (SUMO-1) (GAP-modifying protein 1) (GMP1) (SMT3 homolog 3) (Sentrin) (Ubiquitin-homology domain protein PIC1) (Ubiquitin-like protein SMT3C) (Smt3C) (Ubiquitin-like protein UBL1)
Gene: SUMO1

Interactor 2: SENP6 (Q9GZR1)
Sentrin-specific protease 6 (EC 3.4.22.-) (SUMO-1-specific protease 1) (Sentrin/SUMO-specific protease SENP6)
Gene: SENP6

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	21148299
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Peptidase_C48~Rad60-SLD
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0016925 - protein sumoylation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 101 Hs			1 1112
+	Hs
		902747 SUMO2_HUMAN (1-97): 1.77e-38: 125: 45.36		SENP6_HUMAN (1-1112): 0: 1617: 100.00
+	Mm
		1160381 SUMO3_MOUSE (1-100): 3.1e-40: 130: 46.00		SENP6_MOUSE (1-1109): 0: 1559: 78.79
+	Xl
		80968 SMO2B_XENLA (1-98): 6.18e-38: 124: 44.90		B7TYL1_XENLA (6-1112): 0: 1354: 50.74
+	Hs
		902739 SUMO2_HUMAN (1-97): 1.77e-38: 125: 45.36		SENP7_HUMAN (932-1085): 1.35e-60: 228: 50.00
+	Sp
		140818 PMT3_SCHPO (2-99): 1.41e-36: 121: 51.02		ULP2_SCHPO (359-896): 7.41e-60: 219: 19.42
+	Xl
		80969 SMO2B_XENLA (1-98): 6.18e-38: 124: 44.90		B7TYL2_XENLA (950-1087): 1.32e-54: 208: 45.00
+	Hs
		928213 SUMO1_HUMAN (1-101): 1.01e-41: 134: 100.00		SENP1_HUMAN (525-782): 1.67e-50: 191: 23.08
+	Hs
		902778 SUMO2_HUMAN (1-97): 1.77e-38: 125: 45.36		SENP1_HUMAN (525-782): 1.67e-50: 191: 23.08
+	Hs
		879158 SUMO3_HUMAN (1-97): 1.65e-37: 123: 47.42		SENP1_HUMAN (525-782): 1.67e-50: 191: 23.08
+	Hs
		928203 SUMO1_HUMAN (1-101): 1.01e-41: 134: 100.00		SENP2_HUMAN (613-776): 8.7e-43: 167: 25.00
+	Xl
		1125459 SMO1B_XENLA (1-101): 2.81e-39: 127: 93.14		Q804S7_XENLA (525-833): 7.5e-43: 168: 18.93
+	Xl
		1151579 SMO2B_XENLA (1-98): 6.18e-38: 124: 44.90		Q804S7_XENLA (525-833): 7.5e-43: 168: 18.93
+	Hs
		902760 SUMO2_HUMAN (1-97): 1.77e-38: 125: 45.36		SENP2_HUMAN (613-776): 8.7e-43: 167: 25.00
+	Hs
		879156 SUMO3_HUMAN (1-97): 1.65e-37: 123: 47.42		SENP2_HUMAN (613-776): 8.7e-43: 167: 25.00
+	Xl
		1140103 SMO2B_XENLA (1-98): 6.18e-38: 124: 44.90		Q5XG28_XENLA (589-865): 1.1e-39: 155: 16.78
+	Sp
		140841 PMT3_SCHPO (2-99): 1.41e-36: 121: 51.02		ULP1_SCHPO (614-785): 4.79e-37: 149: 20.12
+	Hs
		902753 SUMO2_HUMAN (1-97): 1.77e-38: 125: 45.36		SENP3_HUMAN (589-865): 1.52e-34: 142: 16.43
+	Xl
		78631 SMO2B_XENLA (1-98): 6.18e-38: 124: 44.90		B6RQN8_XENLA (668-863): 2.12e-28: 124: 18.05
+	Hs
		902714 SUMO2_HUMAN (1-97): 1.77e-38: 125: 45.36		SENP5_HUMAN (668-863): 1.3e-27: 122: 16.59
+	Hs
		879147 SUMO3_HUMAN (1-97): 1.65e-37: 123: 47.42		SENP5_HUMAN (668-863): 1.3e-27: 122: 16.59