HitPredict

Interactor 1: SKP1 (P63208)
S-phase kinase-associated protein 1 (Cyclin-A/CDK2-associated protein p19) (p19A) (Organ of Corti protein 2) (OCP-2) (Organ of Corti protein II) (OCP-II) (RNA polymerase II elongation factor-like protein) (SIII) (Transcription elongation factor B polypeptide 1-like) (p19skp1)
Gene: SKP1

Interactor 2: FBX25 (Q8TCJ0)
F-box only protein 25
Gene: FBXO25

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.89	0.60	0.733

Property	Details
Experiments	32296183, 18287534, 20473970, 16278047, 16714087, unassigned1304
Identification Methods	two hybrid, affinity chromatography technology, anti tag coimmunoprecipitation, validated two hybrid, two hybrid prey pooling approach, two hybrid array, pull down
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0016567 - protein ubiquitination GO:0019005 - SCF ubiquitin ligase complex
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 163 Hs			1 367
+	Hs
		929022 SKP1_HUMAN (1-163): 1.62e-87: 254: 100.00		FBX32_HUMAN (1-367): 8.84e-180: 504: 59.89
+	Mm
		1321638 SKP1_MOUSE (1-163): 8.88e-88: 255: 99.39		FBX32_MOUSE (1-367): 4.23e-174: 490: 58.27
+	Dm
		285034 O77430_DROME (1-163): 1.01e-79: 235: 76.69		Q9VTM4_DROME (1-367): 1.67e-128: 374: 23.69