Protein: FKB59
FK506-binding protein 59 (EC 5.2.1.8) (Peptidyl-prolyl cis-trans isomerase) (PPIase) (Rotamase) (dFKBP59)

Gene: FKB59, Fkbp59
Organism: Drosophila melanogaster
Interactions: 194
UniProt ID: Q9VL78

Gene Ontology (top 5):
GO:0003755 - peptidyl-prolyl cis-trans isomerase activity
GO:0005528 - FK506 binding
GO:0005737 - cytoplasm
GO:0016027 - inaD signaling complex
GO:0050908 - detection of light stimulus involved in visual perception

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1171714

INAD
Inactivation-no-after-potential D protein

2

2

Small-scale

0.600

High

871688

FKB12
Peptidyl-prolyl cis-trans isomerase Fkbp12

1

19

High-throughput

0.575

High

1464351

Q9V3V2
peptidylprolyl isomerase

1

19

High-throughput

0.575

High

1474761

Q9VGK3
peptidylprolyl isomerase

1

17

High-throughput

0.575

High

1475666

Q9VH81
protein-serine/threonine phosphatase

1

3

High-throughput

0.575

High

1480500

Q9VPN5
Stress-induced-phosphoprotein 1

1

17

High-throughput

0.575

High

1480529

Q9W0H8
Reticulocalbin-3

1

10

High-throughput

0.575

High

1480531

Q9W227
Peptidyl-prolyl cis-trans isomerase

1

4

High-throughput

0.575

High

1261760

Q7JRC9
RE73310p

2

3

High-throughput

0.571

High

1445441

SH3BG
SH3 domain-binding glutamic acid-rich protein homolog

2

2

High-throughput

0.571

High

1463688

Q9V3I1
Deoxyuridine 5'-triphosphate nucleotidohydrolase

2

2

High-throughput

0.571

High

1262868

Q7JX87
1-Cys peroxiredoxin

2

5

High-throughput

0.521

High

356433

O97102
Small ubiquitin-related modifier

1

4

High-throughput

0.514

High

1468654

Q9VAY2
Heat shock protein 83

1

20

High-throughput

0.514

High

1478357

Q9VJD4
LD24721p

1

16

High-throughput

0.514

High

305006

CRY1
Cryptochrome-1

1

0

High-throughput

0.493

High

1181160

Q32KD4
Protein argonaute-1

1

12

Small-scale

0.481

High

878219

TRPL
Transient-receptor-potential-like protein

1

13

Small-scale

0.479

High

1273670

AGO3
Protein argonaute-3

1

15

Small-scale

0.479

High

1480515

PYRG
CTP synthase

1

1

High-throughput

0.479

High

57640

A1ZB71
Glutathione S transferase E6

1

5

High-throughput

0.445

High

57863

A1ZB77
Uncharacterized protein, isoform J

1

2

High-throughput

0.445

High

145992

UGDH
UDP-glucose 6-dehydrogenase

1

1

High-throughput

0.445

High

195120

O16043
Anon1A4

1

2

High-throughput

0.445

High

234621

VINC
Vinculin

1

3

High-throughput

0.445

High

305721

IPYR
Inorganic pyrophosphatase

1

3

High-throughput

0.445

High

357595

INO1
Inositol-3-phosphate synthase

1

2

High-throughput

0.445

High

451890

NOTCH
Neurogenic locus Notch protein [Cleaved into: Processed neurogenic locus Notch protein]

1

1

High-throughput

0.445

High

556768

PSA1
Proteasome subunit alpha type-1

1

9

High-throughput

0.445

High

561833

MODU
DNA-binding protein modulo

1

2

High-throughput

0.445

High

578153

ENO
Enolase

1

4

High-throughput

0.445

High

609471

PCNA
Proliferating cell nuclear antigen

1

2

High-throughput

0.445

High

611535

PSA4
Proteasome subunit alpha type-4

1

12

High-throughput

0.445

High

616627

ARM
Armadillo segment polarity protein

1

1

High-throughput

0.445

High

632997

GLNA1
Glutamine synthetase 1, mitochondrial

1

1

High-throughput

0.445

High

648949

ANXB9
Annexin B9

1

6

High-throughput

0.445

High

649115

ANX10
Annexin B10

1

6

High-throughput

0.445

High

682820

PROF
Profilin

1

2

High-throughput

0.445

High

762629

UCHL
Ubiquitin carboxyl-terminal hydrolase

1

9

High-throughput

0.445

High

856118

MOEH
Moesin/ezrin/radixin homolog 1

1

4

High-throughput

0.445

High

929043

DOD
Putative peptidyl-prolyl cis-trans isomerase dodo

1

2

High-throughput

0.445

High

929566

PDI
Protein disulfide-isomerase

1

12

High-throughput

0.445

High

1019662

TRXR1
Thioredoxin reductase 1, mitochondrial

1

5

High-throughput

0.445

High

1019921

1433E
14-3-3 protein epsilon

1

3

High-throughput

0.445

High

1069908

Q0E993
Valine--tRNA ligase

1

3

High-throughput

0.445

High

1176604

NLP
Nucleoplasmin-like protein

1

7

High-throughput

0.445

High

1260876

Q76NR6
Regucalcin

1

4

High-throughput

0.445

High

1264149

Q7K0E6
Aspartate--tRNA ligase, cytoplasmic

1

2

High-throughput

0.445

High

1267962

TERA
Transitional endoplasmic reticulum ATPase TER94

1

6

High-throughput

0.445

High

1268287

Q7KN99
Phosphopantothenoylcysteine synthetase, isoform A

1

2

High-throughput

0.445

High

1269494

Q7KTW5
Inositol-1-monophosphatase

1

2

High-throughput

0.445

High

1305766

Q8IQZ7
FI19014p1

1

5

High-throughput

0.445

High

1321992

Q8MYY7
RE44624p

1

20

High-throughput

0.445

High

1343051

Q8STA5
Histidine triad nucleotide binding protein 1, isoform A

1

2

High-throughput

0.445

High

1343347

OLA1
Obg-like ATPase 1

1

6

High-throughput

0.445

High

1345286

Q8T0L3
E1 ubiquitin-activating enzyme

1

4

High-throughput

0.445

High

1374579

NACA
Nascent polypeptide-associated complex subunit alpha

1

4

High-throughput

0.445

High

1377686

FAXC
Failed axon connections

1

3

High-throughput

0.445

High

1427877

IF5A
Eukaryotic translation initiation factor 5A

1

3

High-throughput

0.445

High

1440602

PUR6
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

1

2

High-throughput

0.445

High

1467742

Q9VAC4
GEO09167p1

1

7

High-throughput

0.445

High

1472476

Q9VEB1
Malate dehydrogenase, mitochondrial

1

2

High-throughput

0.445

High

1475128

TCTP
Translationally-controlled tumor protein homolog

1

2

High-throughput

0.445

High

1476625

DPP3
Dipeptidyl peptidase 3

1

1

High-throughput

0.445

High

1479303

Q9VKB0
threonine--tRNA ligase

1

4

High-throughput

0.445

High

1480492

AK200
A-kinase anchor protein 200

1

4

High-throughput

0.445

High

1480493

SYAC
Alanine--tRNA ligase, cytoplasmic

1

6

High-throughput

0.445

High

1480496

Q9VN44
FI07923p

1

1

High-throughput

0.445

High

1480501

Q9VPX6
Adenylyl cyclase-associated protein

1

2

High-throughput

0.445

High

1480504

Q9VQL1
serine--tRNA ligase

1

6

High-throughput

0.445

High

1480505

Q9VRD6
NTF2-related export protein

1

2

High-throughput

0.445

High

1480509

Q9VSL2
Glutathione S transferase O3

1

5

High-throughput

0.445

High

1480513

Q9VUC1
Hsc70Cb, isoform A

1

16

High-throughput

0.445

High

1480516

Y9705
Cold shock domain-containing protein CG9705

1

2

High-throughput

0.445

High

1480524

CLIC
Chloride intracellular channel Clic

1

6

High-throughput

0.445

High

1480530

SND1
Staphylococcal nuclease domain-containing protein 1

1

7

High-throughput

0.445

High

1480532

Q9W2M4
Farnesoic acid O-methyl transferase domain-containing protein

1

1

High-throughput

0.445

High

1480533

Q9W3F6
Bleomycin hydrolase

1

1

High-throughput

0.445

High

1480535

Q9W3Y3
Calcyclin-binding protein

1

12

High-throughput

0.445

High

1480538

Q9W457
Serine hydroxymethyltransferase

1

2

High-throughput

0.445

High

1480541

Q9XYZ9
Glutathione S transferase E12, isoform A

1

5

High-throughput

0.445

High

1480542

Q9XZ57
Eb1, isoform E

1

2

High-throughput

0.445

High

1480544

PURA
Adenylosuccinate synthetase

1

2

High-throughput

0.445

High

1472039

INO80
Chromatin-remodeling ATPase INO80

1

1

High-throughput

0.442

High

1474858

Q9VGM2
Fatty acid-binding protein, muscle

1

5

High-throughput

0.437

High

356579

O97121
cystathionine gamma-lyase

1

0

High-throughput

0.426

High

1463339

Q9V3D8
GH27579p

1

0

High-throughput

0.426

High

1477565

Q9VII9
Glyoxylate reductase/hydroxypyruvate reductase

1

0

High-throughput

0.426

High

1480495

ITPA
Inosine triphosphate pyrophosphatase

1

0

High-throughput

0.426

High

1480514

GARS
Glycine--tRNA ligase

1

0

High-throughput

0.426

High

47800

A0AQH0
Proteasome subunit beta

1

11

High-throughput

0.407

High

54081

A1Z892
1-Cys peroxiredoxin

1

5

High-throughput

0.407

High

86569

B9EQV3
Endoplasmic reticulum transmembrane protein

1

3

High-throughput

0.407

High

121316

ALDR
Aldo-keto reductase 1B

1

14

High-throughput

0.407

High

197860

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

2

High-throughput

0.407

High

234783

O46067
Hypoxia up-regulated protein 1

1

15

High-throughput

0.407

High

304706

RS21
Small ribosomal subunit protein eS21

1

2

High-throughput

0.407

High

305262

TRMB
tRNA

1

2

High-throughput

0.407

High

357368

O97428
Ciboulot, isoform A

1

4

High-throughput

0.407

High

426790

HP1
Heterochromatin protein 1

1

2

High-throughput

0.407

High

460155

ALF
Fructose-bisphosphate aldolase

1

2

High-throughput

0.407

High

477028

NDKA
Nucleoside diphosphate kinase

1

3

High-throughput

0.407

High

712415

CALR
Calreticulin

1

4

High-throughput

0.407

High

726456

VATB
V-type proton ATPase subunit B

1

6

High-throughput

0.407

High

821916

PSA2
Proteasome subunit alpha type-2

1

10

High-throughput

0.407

High

835200

6PGD
6-phosphogluconate dehydrogenase, decarboxylating

1

4

High-throughput

0.407

High

874712

RIR2
Ribonucleoside-diphosphate reductase subunit M2

1

2

High-throughput

0.407

High

930215

VATE
V-type proton ATPase subunit E

1

2

High-throughput

0.407

High

1026662

SODM
Superoxide dismutase [Mn], mitochondrial

1

1

High-throughput

0.407

High

1031264

PGK
Phosphoglycerate kinase

1

2

High-throughput

0.407

High

1052281

HMGD
High mobility group protein D

1

3

High-throughput

0.407

High

1052478

ATPB
ATP synthase subunit beta, mitochondrial

1

5

High-throughput

0.407

High

1070818

Q0KHZ6
Electron transfer flavoprotein subunit beta

1

2

High-throughput

0.407

High

1176340

VATA2
V-type proton ATPase catalytic subunit A isoform 2

1

7

High-throughput

0.407

High

1176745

SAHH
Adenosylhomocysteinase

1

2

High-throughput

0.407

High

1191710

Q3YMU0
Protein disulfide-isomerase

1

9

High-throughput

0.407

High

1261565

Q7JR58
Probable enoyl-CoA hydratase, mitochondrial

1

1

High-throughput

0.407

High

1262175

Q7JVH6
LD24696p

1

14

High-throughput

0.407

High

1263053

Q7JXC4
CG6459 protein

1

2

High-throughput

0.407

High

1264722

Q7K148
Proteasome subunit beta

1

10

High-throughput

0.407

High

1265304

Q7K2K2
FI04612p

1

2

High-throughput

0.407

High

1265846

Q7K3J0
T-complex protein 1 subunit theta

1

1

High-throughput

0.407

High

1266817

EIF3J
Eukaryotic translation initiation factor 3 subunit J

1

1

High-throughput

0.407

High

1268104

Q7KN85
ATP-citrate synthase

1

2

High-throughput

0.407

High

1303964

Q8INK3
Fatty acid-binding protein, muscle

1

5

High-throughput

0.407

High

1306153

Q8IRD3
Glutathione peroxidase

1

2

High-throughput

0.407

High

1321721

Q8MT58
Carnosine dipeptidase 2, isoform A

1

2

High-throughput

0.407

High

1344454

Q8SYG3
E2 ubiquitin-conjugating enzyme

1

4

High-throughput

0.407

High

1374705

ACPM
Acyl carrier protein, mitochondrial

1

2

High-throughput

0.407

High

1374798

SUCA
Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial

1

2

High-throughput

0.407

High

1376932

PSA5
Proteasome subunit alpha type-5

1

8

High-throughput

0.407

High

1440065

JUPIT
Microtubule-associated protein Jupiter

1

2

High-throughput

0.407

High

1440175

NASP
Nuclear autoantigenic sperm protein homolog

1

2

High-throughput

0.407

High

1445641

CP2B
Cardio acceleratory peptide 2b

1

2

High-throughput

0.407

High

1464522

SPC25
Kinetochore protein Spc25

1

2

High-throughput

0.407

High

1464603

Q9V3V9
Endonuclease G inhibitor, isoform A

1

2

High-throughput

0.407

High

1465049

THIO2
Thioredoxin-2

1

7

High-throughput

0.407

High

1465277

PDIA6
Protein disulfide-isomerase A6 homolog

1

9

High-throughput

0.407

High

1466079

PSA3
Proteasome subunit alpha type-3

1

14

High-throughput

0.407

High

1466273

TPP2
Tripeptidyl-peptidase 2

1

1

High-throughput

0.407

High

1466987

Q9V9U3
LD45254p

1

3

High-throughput

0.407

High

1467649

Q9VAC1
GM14349p

1

2

High-throughput

0.407

High

1468201

Q9VAN7
Phosphoglycerate mutase

1

2

High-throughput

0.407

High

1469532

Q9VBR6
RE74917p

1

2

High-throughput

0.407

High

1469609

Q9VBT1
CHK kinase-like domain-containing protein

1

2

High-throughput

0.407

High

1470524

Q9VCK6
LD34157p

1

2

High-throughput

0.407

High

1470987

Q9VD02
GH14779p

1

5

High-throughput

0.407

High

1471155

Q9VD29
small monomeric GTPase

1

5

High-throughput

0.407

High

1472923

FLNA
Filamin-A

1

2

High-throughput

0.407

High

1474300

Q9VG31
Malic enzyme

1

1

High-throughput

0.407

High

1474355

Q9VG33
Sulfurtransferase

1

2

High-throughput

0.407

High

1475940

TEBPH
Cytosolic Prostaglandin E synthase

1

11

High-throughput

0.407

High

1476471

Q9VHN7
transketolase

1

4

High-throughput

0.407

High

1476875

Q9VHX4
LD24679p

1

14

High-throughput

0.407

High

1477372

Q9VIE8
Aconitate hydratase, mitochondrial

1

3

High-throughput

0.407

High

1478489

Q9VJJ0
Proteasome subunit beta

1

14

High-throughput

0.407

High

1479226

Q9VK60
GH25425p

1

5

High-throughput

0.407

High

1479909

Q9VKW5
Prolyl endopeptidase

1

3

High-throughput

0.407

High

1480075

Q9VKZ8
Ubiquitin carboxyl-terminal hydrolase

1

2

High-throughput

0.407

High

1480163

EF1D
Probable elongation factor 1-delta

1

3

High-throughput

0.407

High

1480352

Q9VL68
Enoyl-CoA delta isomerase 1, mitochondrial

1

4

High-throughput

0.407

High

1480416

Q9VL70
HL08109p

1

2

High-throughput

0.407

High

1480491

Q9VLB7
Rab GDP dissociation inhibitor

1

4

High-throughput

0.407

High

1480494

Q9VMU6
LD31822p

1

2

High-throughput

0.407

High

1480497

PSB4
Proteasome subunit beta type-4

1

20

High-throughput

0.407

High

1480498

Q9VNB2
RE42193p

1

2

High-throughput

0.407

High

1480499

Q9VP52
GH24315p

1

2

High-throughput

0.407

High

1480502

Q9VQ61
Aspartate aminotransferase

1

1

High-throughput

0.407

High

1480503

BACC
Bacchus

1

2

High-throughput

0.407

High

1480506

Q9VRL1
GEO06356p1

1

3

High-throughput

0.407

High

1480507

Q9VRP2
Uncharacterized protein, isoform A

1

2

High-throughput

0.407

High

1480508

Q9VSI6
Isocitrate dehydrogenase [NADP]

1

2

High-throughput

0.407

High

1480510

Q9VTY2
Uncharacterized protein, isoform A

1

14

High-throughput

0.407

High

1480511

Q9VU35
10 kDa heat shock protein, mitochondrial

1

2

High-throughput

0.407

High

1480512

WDR1
Actin-interacting protein 1

1

9

High-throughput

0.407

High

1480518

Q9VVL7
Dihydrolipoyl dehydrogenase

1

5

High-throughput

0.407

High

1480519

Q9VW59
Rho GDP-dissociation inhibitor 3

1

2

High-throughput

0.407

High

1480520

Q9VW70
FI21813p1

1

3

High-throughput

0.407

High

1480521

RS10B
Small ribosomal subunit protein eS10B

1

4

High-throughput

0.407

High

1480522

DHB4
Peroxisomal multifunctional enzyme type 2

1

2

High-throughput

0.407

High

1480523

Q9VXQ3
Diphosphomevalonate decarboxylase

1

2

High-throughput

0.407

High

1480525

TXND5
Thioredoxin domain-containing protein 5 homolog

1

14

High-throughput

0.407

High

1480526

Q9VZI1
Transgelin

1

6

High-throughput

0.407

High

1480527

Q9VZY0
LD45195p

1

2

High-throughput

0.407

High

1480528

Q9W022
GEO01508p1

1

10

High-throughput

0.407

High

1480534

Q9W3X6
fumarate hydratase

1

2

High-throughput

0.407

High

1480536

CISY
Probable citrate synthase, mitochondrial

1

4

High-throughput

0.407

High

1480537

WUHO
tRNA

1

11

High-throughput

0.407

High

1480539

Q9W478
RE43153p

1

3

High-throughput

0.407

High

1480540

PSB3
Proteasome subunit beta type-3

1

14

High-throughput

0.407

High

1480543

PSA6
Proteasome subunit alpha type-6

1

14

High-throughput

0.407

High

1480545

Q9Y112
BcDNA.GH10614

1

14

High-throughput

0.407

High

52454

A1Z6X6
Lactoylglutathione lyase

1

0

High-throughput

0.232

Low

1480517

Q9VVC5
2-oxoglutarate dehydrogenase, mitochondrial

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025