HitPredict

Interactor 1: SKP1 (P63208)
S-phase kinase-associated protein 1 (Cyclin-A/CDK2-associated protein p19) (p19A) (Organ of Corti protein 2) (OCP-2) (Organ of Corti protein II) (OCP-II) (RNA polymerase II elongation factor-like protein) (SIII) (Transcription elongation factor B polypeptide 1-like) (p19skp1)
Gene: SKP1

Interactor 2: ANC2 (Q9UJX6)
Anaphase-promoting complex subunit 2 (APC2) (Cyclosome subunit 2)
Gene: ANAPC2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Cullin~Skp1_POZ
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 163 Hs			1 822
+	Hs
		928902 SKP1_HUMAN (1-163): 1.62e-87: 254: 100.00		CUL4A_HUMAN (244-806): 1.6e-151: 464: 16.42
+	Hs
		928903 SKP1_HUMAN (1-163): 1.62e-87: 254: 100.00		CUL4B_HUMAN (244-812): 1.06e-144: 451: 16.06
+	Mm
		1376703 SKP1_MOUSE (1-163): 8.88e-88: 255: 99.39		CUL1_MOUSE (171-811): 4.78e-137: 426: 13.85
+	Hs
		928899 SKP1_HUMAN (1-163): 1.62e-87: 254: 100.00		CUL1_HUMAN (171-811): 5.04e-137: 426: 13.85
+	Hs
		928901 SKP1_HUMAN (1-163): 1.62e-87: 254: 100.00		CUL3_HUMAN (243-808): 2.97e-135: 421: 14.93
+	Dm
		284981 O77430_DROME (1-163): 1.01e-79: 235: 76.69		Q5BI50_DROME (242-806): 4.9e-138: 431: 16.44
+	Ce
		106725 G5EE67_CAEEL (4-162): 3.47e-67: 203: 54.66		CUL6_CAEEL (138-806): 1.33e-140: 434: 12.81
+	Dm
		285002 O77430_DROME (1-163): 1.01e-79: 235: 76.69		Q95TK2_DROME (370-819): 2.09e-131: 401: 46.71
+	Hs
		928900 SKP1_HUMAN (1-163): 1.62e-87: 254: 100.00		CUL2_HUMAN (270-802): 8.7e-120: 381: 12.77
+	Dm
		284976 O77430_DROME (1-163): 1.01e-79: 235: 76.69		CUL1_DROME (171-811): 7.67e-120: 381: 12.76
+	At
		1277333 ASK4_ARATH (4-162): 3.51e-74: 220: 52.80		CUL1_ARATH (154-808): 3.92e-121: 384: 13.56
+	Dm
		1097192 Q7KJ69_DROME (1-163): 1.92e-74: 221: 67.49		CUL1_DROME (171-811): 7.67e-120: 381: 12.76
+	At
		1277346 ASK3_ARATH (4-162): 1.06e-72: 217: 50.31		CUL1_ARATH (154-808): 3.92e-121: 384: 13.56
+	At
		1107618 SKP1A_ARATH (3-162): 7.36e-72: 215: 57.76		CUL1_ARATH (154-808): 3.92e-121: 384: 13.56
+	At
		1277329 SKP1B_ARATH (3-162): 1.58e-70: 211: 55.56		CUL1_ARATH (154-808): 3.92e-121: 384: 13.56
+	At
		221655 ASK11_ARATH (4-162): 4.62e-70: 210: 54.72		CUL1_ARATH (154-808): 3.92e-121: 384: 13.56
+	Ce
		105467 SKR1_CAEEL (4-162): 2.25e-78: 232: 70.81		CUL1_CAEEL (129-803): 4.11e-111: 359: 12.26
+	At
		1277337 ASK10_ARATH (3-162): 3.61e-68: 205: 49.38		CUL1_ARATH (154-808): 3.92e-121: 384: 13.56
+	Sp
		142922 SKP1_SCHPO (1-163): 6.54e-73: 217: 56.36		CUL1_SCHPO (158-806): 2.07e-111: 359: 13.06
+	Ce
		106724 G5EE67_CAEEL (4-162): 3.47e-67: 203: 54.66		CUL1_CAEEL (129-803): 4.11e-111: 359: 12.26