HitPredict

Interactor 1: SKP1 (P63208)
S-phase kinase-associated protein 1 (Cyclin-A/CDK2-associated protein p19) (p19A) (Organ of Corti protein 2) (OCP-2) (Organ of Corti protein II) (OCP-II) (RNA polymerase II elongation factor-like protein) (SIII) (Transcription elongation factor B polypeptide 1-like) (p19skp1)
Gene: SKP1

Interactor 2: FBW1B (Q9UKB1)
F-box/WD repeat-containing protein 11 (F-box and WD repeats protein beta-TrCP2) (F-box/WD repeat-containing protein 1B) (Homologous to Slimb protein) (HOS)
Gene: FBXW11

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.97 1.00 0.990

The method score is based on:

Property Details
Experiments 26496610, 29150431, 27705803, 29435596, 33961781, 12165731, 19159283, 25332235, 25900982, 25515538, 30254149, 10644755, 32350066, 19615732, 15070733, 10321728, 10230406, 24500709, 20596027, 25609649 and 2 others

more...
Identification Methods affinity chromatography technology, pull down, two hybrid, anti tag coimmunoprecipitation, mammalian protein protein interaction trap, tandem affinity purification, coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains F-box-like~Skp1
Common GO terms GO:0000209 - protein polyubiquitination
GO:0005634 - nucleus
GO:0005813 - centrosome
GO:0005829 - cytosol
GO:0016567 - protein ubiquitination
and 4 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 163
Hs

1 542
+ Mm
+ Hs
+ Mm
+ Mm
+ Hs
+ Sp
+ Dm
+ Dm
+ Dm
+ Ce
+ Ce
+ Sp
+ Hs
+ Sp
+ Hs
+ Xl
+ Dm
+ Mm
+ Sc
+ Sp

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024