HitPredict

Interactor 1: SKP1 (P63208)
S-phase kinase-associated protein 1 (Cyclin-A/CDK2-associated protein p19) (p19A) (Organ of Corti protein 2) (OCP-2) (Organ of Corti protein II) (OCP-II) (RNA polymerase II elongation factor-like protein) (SIII) (Transcription elongation factor B polypeptide 1-like) (p19skp1)
Gene: SKP1

Interactor 2: FBXL2 (Q9UKC9)
F-box/LRR-repeat protein 2 (F-box and leucine-rich repeat protein 2) (F-box protein FBL2/FBL3)
Gene: FBXL2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.96 1.00 0.982

The method score is based on:

Property Details
Experiments 10531037, 27705803, 32296183, 33961781, 37071682, 26790640, 28614300, 34635651, 36662618, 22399757, 10508920, 23604317, unassigned1304, 19159283
Identification Methods pull down, affinity chromatography technology, two hybrid, cross-linking study, anti bait coimmunoprecipitation, two hybrid prey pooling approach, two hybrid array, mammalian protein protein interaction trap, validated two hybrid, anti tag coimmunoprecipitation and 1 others

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Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains F-box-like~Skp1
Common GO terms GO:0005737 - cytoplasm
GO:0006513 - protein monoubiquitination
GO:0016567 - protein ubiquitination
GO:0019005 - SCF ubiquitin ligase complex
GO:0031146 - SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
and 1 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 163
Hs

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Last updated: 15 Jul 2024