HitPredict

Interactor 1: RACK1 (P63244)
Small ribosomal subunit protein RACK1 (Cell proliferation-inducing gene 21 protein) (Guanine nucleotide-binding protein subunit beta-2-like 1) (Guanine nucleotide-binding protein subunit beta-like protein 12.3) (Human lung cancer oncogene 7 protein) (HLC-7) (Receptor for activated C kinase) (Receptor of activated protein C kinase 1) [Cleaved into: Small ribosomal subunit protein RACK1, N-terminally processed (Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed) (Receptor of activated protein C kinase 1, N-terminally processed)]
Gene: RACK1

Interactor 2: PDE4D (Q08499)
3',5'-cyclic-AMP phosphodiesterase 4D (EC 3.1.4.53) (DPDE3) (PDE43) (cAMP-specific phosphodiesterase 4D)
Gene: PDE4D

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.82	0.60	0.704

Property	Details
Experiments	12193273, 10329691, 11516626, 19372219
Identification Methods	pull down, affinity chromatography technology, two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0019899 - enzyme binding GO:0033137 - negative regulation of peptidyl-serine phosphorylation GO:0048471 - perinuclear region of cytoplasm
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 317 Hs			1 809
+	Hs
		792977 LIS1_HUMAN (144-316): 6.1e-46: 162: 23.43		PDE4D_HUMAN (1-809): 0: 1225: 100.00
+	Hs
		792976 LIS1_HUMAN (144-316): 6.1e-46: 162: 23.43		PDE4B_HUMAN (153-799): 0: 905: 76.46
+	Hs
		283300 WDR5_HUMAN (3-219): 3.42e-62: 202: 26.70		PDE9A_HUMAN (380-717): 1.17e-126: 393: 28.99