Protein: FKBP4
FK506-binding protein 4 (EC 5.2.1.8) (Histone proline isomerase) (Peptidyl-prolyl cis-trans isomerase) (PPIase) (Rotamase)

Gene: FKBP4, FPR4
Organism: Saccharomyces cerevisiae S288C
Interactions: 170
UniProt ID: Q06205

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0003755 - peptidyl-prolyl cis-trans isomerase activity
GO:0005527 - macrolide binding
GO:0005634 - nucleus
GO:0005730 - nucleolus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

743291

PP12
Serine/threonine-protein phosphatase PP1-2

3

3

High-throughput

0.855

High

1054246

FKBP4
FK506-binding protein 4

3

12

Small-scale

0.821

High

807151

FKBP3
Peptidyl-prolyl cis-trans isomerase

3

15

High-throughput

0.812

High

963729

H3
Histone H3

6

7

Small-scale

0.732

High

586027

CSK21
Casein kinase II subunit alpha

2

11

High-throughput

0.712

High

623018

CSK22
Casein kinase II subunit alpha'

2

12

High-throughput

0.712

High

782451

RPF2
Ribosome biogenesis protein RPF2

4

4

High-throughput

0.697

High

382358

H4
Histone H4

4

5

Small-scale

0.692

High

850018

LOC1
60S ribosomal subunit assembly/export protein LOC1

4

1

High-throughput

0.690

High

1054266

NOP53
Ribosome biogenesis protein NOP53

4

1

Small-scale

0.680

High

1044900

RRP17
Ribosomal RNA-processing protein 17

4

1

High-throughput

0.674

High

814389

NOC2
Nucleolar complex protein 2

3

3

High-throughput

0.669

High

1047282

ERB1
Ribosome biogenesis protein ERB1

3

7

High-throughput

0.667

High

830184

NOP2
25S rRNA

3

5

High-throughput

0.662

High

682388

SPB4
ATP-dependent rRNA helicase SPB4

3

8

High-throughput

0.656

High

816906

NUG1
Nuclear GTP-binding protein NUG1

3

2

High-throughput

0.656

High

1039633

NOG1
Nucleolar GTP-binding protein 1

3

5

Small-scale

0.656

High

677241

SPB1
27S pre-rRNA

3

2

High-throughput

0.646

High

780322

EBP2
rRNA-processing protein EBP2

3

2

High-throughput

0.646

High

917561

NSA1
Ribosome biogenesis protein NSA1

3

1

Small-scale

0.640

High

919003

PESC
Pescadillo homolog

3

3

High-throughput

0.640

High

637285

PWP1
Periodic tryptophan protein 1

2

3

High-throughput

0.621

High

1054261

HRK1
Serine/threonine-protein kinase HRK1

1

5

High-throughput

0.618

High

364752

CDK1
Cyclin-dependent kinase 1

1

6

High-throughput

0.618

High

1054271

SMT3
Ubiquitin-like protein SMT3

1

5

High-throughput

0.618

High

1046515

PUF6
Pumilio homology domain family member 6

2

3

High-throughput

0.611

High

1054253

NOC3
Nucleolar complex-associated protein 3

2

4

High-throughput

0.611

High

1054256

NOP12
Nucleolar protein 12

2

6

High-throughput

0.594

High

826085

ULP2
Ubiquitin-like-specific protease 2

2

3

High-throughput

0.586

High

633192

MAK11
Protein MAK11

2

6

Small-scale

0.584

High

804666

SSF1
Ribosome biogenesis protein SSF1

2

1

Small-scale

0.584

High

827612

RLP7
Ribosome biogenesis protein RLP7

2

3

High-throughput

0.584

High

924848

NOP15
Ribosome biogenesis protein 15

2

5

High-throughput

0.584

High

1043286

HAS1
ATP-dependent RNA helicase HAS1

2

9

High-throughput

0.584

High

1054265

YTM1
Ribosome biogenesis protein YTM1

2

9

High-throughput

0.584

High

1054272

DBP10
ATP-dependent RNA helicase DBP10

2

4

High-throughput

0.584

High

924191

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

2

4

High-throughput

0.576

High

687084

PPZ1
Serine/threonine-protein phosphatase PP-Z1

1

3

High-throughput

0.575

High

743421

TOR2
Serine/threonine-protein kinase TOR2

1

8

High-throughput

0.575

High

419880

H2A2
Histone H2A.2

2

2

High-throughput

0.571

High

792257

GBLP
Small ribosomal subunit protein RACK1

2

8

High-throughput

0.571

High

805094

RPF1
Ribosome production factor 1

2

2

High-throughput

0.571

High

823044

ATAD2
ATPase histone chaperone YTA7

2

10

High-throughput

0.571

High

1054274

H2AZ
Histone H2A.Z

2

7

High-throughput

0.571

High

580100

HSC82
ATP-dependent molecular chaperone HSC82

1

16

High-throughput

0.553

High

546356

SSB1
Ribosome-associated molecular chaperone SSB1

2

15

High-throughput

0.552

High

851020

CSK2B
Casein kinase II subunit beta

2

2

High-throughput

0.552

High

722272

XPO1
Exportin-1

1

2

High-throughput

0.536

High

917484

PRP43
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43

1

2

High-throughput

0.536

High

1030578

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

5

High-throughput

0.536

High

1042375

GCN5
Histone acetyltransferase GCN5

1

4

High-throughput

0.536

High

1044221

ARX1
Probable metalloprotease ARX1

1

5

High-throughput

0.536

High

1054252

RIX7
Ribosome biogenesis ATPase RIX7

1

8

High-throughput

0.536

High

700296

GAR1
H/ACA ribonucleoprotein complex subunit GAR1

1

0

High-throughput

0.518

High

684849

RL5
Large ribosomal subunit protein uL18

1

0

High-throughput

0.513

High

817319

YEN1
Holliday junction resolvase YEN1

1

0

High-throughput

0.513

High

432706

RL7A
Large ribosomal subunit protein uL30A

1

3

High-throughput

0.489

High

923128

BRE5
UBP3-associated protein BRE5

1

4

High-throughput

0.489

High

743558

RU1A
U1 small nuclear ribonucleoprotein A

1

0

High-throughput

0.486

High

1038107

ULP1
Ubiquitin-like-specific protease 1

1

3

High-throughput

0.481

High

149963

RS9A
Small ribosomal subunit protein uS4A

1

3

High-throughput

0.479

High

402119

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

1

High-throughput

0.479

High

435371

RS3
Small ribosomal subunit protein uS3

1

2

High-throughput

0.479

High

512662

RS6A
Small ribosomal subunit protein eS6A

1

1

High-throughput

0.479

High

534144

MAK16
Protein MAK16

1

1

High-throughput

0.479

High

644994

RPA2
DNA-directed RNA polymerase I subunit RPA135

1

4

High-throughput

0.479

High

677572

KRR1
KRR1 small subunit processome component

1

1

High-throughput

0.479

High

689142

RL16A
Large ribosomal subunit protein uL13A

1

1

High-throughput

0.479

High

689671

RS7A
Small ribosomal subunit protein eS7A

1

1

High-throughput

0.479

High

708236

TF2B
Transcription initiation factor IIB

1

5

High-throughput

0.479

High

708787

TF3B
Transcription factor IIIB 70 kDa subunit

1

5

High-throughput

0.479

High

727325

HS104
Heat shock protein 104

1

3

High-throughput

0.479

High

735169

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

2

High-throughput

0.479

High

746675

DRS1
ATP-dependent RNA helicase DRS1

1

6

High-throughput

0.479

High

750149

MRT4
Ribosome assembly factor MRT4

1

2

High-throughput

0.479

High

763120

RRP1
Ribosomal RNA-processing protein 1

1

2

High-throughput

0.479

High

780708

RRP14
Ribosomal RNA-processing protein 14

1

1

High-throughput

0.479

High

791112

NOP4
Nucleolar protein 4

1

1

High-throughput

0.479

High

795845

YBC8
UPF0642 protein YBL028C

1

1

High-throughput

0.479

High

798316

ENP1
Essential nuclear protein 1

1

1

High-throughput

0.479

High

803938

CIC1
Proteasome-interacting protein CIC1

1

2

High-throughput

0.479

High

816798

NOP16
Nucleolar protein 16

1

1

High-throughput

0.479

High

818277

NSA2
Ribosome biogenesis protein NSA2

1

2

High-throughput

0.479

High

826851

DSN1
Kinetochore-associated protein DSN1

1

1

High-throughput

0.479

High

844619

UTP10
U3 small nucleolar RNA-associated protein 10

1

2

High-throughput

0.479

High

865755

MOG1
Nuclear import protein MOG1

1

3

High-throughput

0.479

High

897511

UBC9
SUMO-conjugating enzyme UBC9

1

1

High-throughput

0.479

High

924333

NOP13
Nucleolar protein 13

1

1

High-throughput

0.479

High

925069

APJ1
J domain-containing protein APJ1

1

4

High-throughput

0.479

High

932234

ORC1
Origin recognition complex subunit 1

1

4

High-throughput

0.479

High

1042239

TOM1
E3 ubiquitin-protein ligase TOM1

1

6

High-throughput

0.479

High

1046036

DHR1
Probable ATP-dependent RNA helicase DHR1

1

4

High-throughput

0.479

High

1046116

RRB1
Ribosome assembly protein RRB1

1

3

High-throughput

0.479

High

1051612

HRQ1
ATP-dependent helicase HRQ1

1

2

Small-scale

0.479

High

1054163

PDP3
NuA3 HAT complex component PDP3

1

3

High-throughput

0.479

High

1054247

JIP5
WD repeat-containing protein JIP5

1

4

High-throughput

0.479

High

1054248

DBP9
ATP-dependent RNA helicase DBP9

1

4

High-throughput

0.479

High

1054249

RRP15
Ribosomal RNA-processing protein 15

1

1

High-throughput

0.479

High

1054250

NOC4
Nucleolar complex protein 4

1

6

High-throughput

0.479

High

1054254

RLP24
Ribosome biogenesis protein RLP24

1

1

High-throughput

0.479

High

1054257

BRX1
Ribosome biogenesis protein BRX1

1

13

High-throughput

0.479

High

1054260

SGO1
Shugoshin

1

1

High-throughput

0.479

High

1054263

RRS1
Regulator of ribosome biosynthesis

1

1

High-throughput

0.479

High

1054264

NIP7
60S ribosome subunit biogenesis protein NIP7

1

1

High-throughput

0.479

High

1054267

RRP6
Exosome complex exonuclease RRP6

1

1

High-throughput

0.479

High

1054268

SCC1
Sister chromatid cohesion protein 1

1

1

High-throughput

0.479

High

1054269

RL7B
Large ribosomal subunit protein uL30B

1

3

High-throughput

0.479

High

1054273

IF6
Eukaryotic translation initiation factor 6

1

3

High-throughput

0.479

High

436180

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.458

High

442119

RS14A
Small ribosomal subunit protein uS11A

1

0

High-throughput

0.458

High

674845

RS2
Small ribosomal subunit protein uS5

1

0

High-throughput

0.458

High

806659

RIX1
Pre-rRNA-processing protein RIX1

1

0

Small-scale

0.458

High

1044758

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.458

High

1045169

SIZ1
E3 SUMO-protein ligase SIZ1

1

0

High-throughput

0.458

High

738264

NHP2
H/ACA ribonucleoprotein complex subunit NHP2

1

2

High-throughput

0.457

High

1054259

RTC1
Restriction of telomere capping protein 1

1

5

High-throughput

0.457

High

381272

H2B1
Histone H2B.1

1

4

High-throughput

0.445

High

381641

H2B2
Histone H2B.2

1

4

High-throughput

0.445

High

486321

TBA1
Tubulin alpha-1 chain

1

3

High-throughput

0.445

High

525216

HSP71
Heat shock protein SSA1

1

15

High-throughput

0.445

High

527730

HSP72
Heat shock protein SSA2

1

15

High-throughput

0.445

High

781806

SET3
SET domain-containing protein 3

1

2

High-throughput

0.445

High

805961

CRP1
Cruciform DNA-recognizing protein 1 [Cleaved into: CRP1 short N-terminal subpeptide; CRP1 short C-terminal subpeptide]

1

1

High-throughput

0.445

High

807789

CSK2C
Casein kinase II subunit beta'

1

2

High-throughput

0.445

High

817636

UTP7
U3 small nucleolar RNA-associated protein 7

1

5

High-throughput

0.445

High

819852

SSB2
Ribosome-associated molecular chaperone SSB2

1

15

High-throughput

0.445

High

858248

RPA43
DNA-directed RNA polymerase I subunit RPA43

1

1

Small-scale

0.445

High

863186

YPP1
Cargo-transport protein YPP1

1

1

High-throughput

0.445

High

863954

SET2
Histone-lysine N-methyltransferase, H3 lysine-36 specific

1

3

High-throughput

0.445

High

925448

RCM1
25S rRNA

1

5

High-throughput

0.445

High

1025180

SEN1
Helicase SEN1

1

3

Small-scale

0.445

High

1044150

GIS1
Transcriptional activator/repressor GIS1

1

2

High-throughput

0.445

High

1049091

YM91
Putative methyltransferase YMR310C

1

1

High-throughput

0.445

High

1054255

BUD20
Bud site selection protein 20

1

1

High-throughput

0.445

High

1054270

RLM1
Transcription factor RLM1

1

1

High-throughput

0.445

High

918046

CGR1
rRNA-processing protein CGR1

1

0

High-throughput

0.438

High

921167

H1
Histone H1

1

0

High-throughput

0.438

High

433857

RL26A
Large ribosomal subunit protein uL24A

1

1

High-throughput

0.437

High

455271

RS19A
Small ribosomal subunit protein eS19A

1

1

High-throughput

0.437

High

503250

RS22A
Small ribosomal subunit protein uS8A

1

3

High-throughput

0.437

High

511298

RL20B
Large ribosomal subunit protein eL20B

1

1

High-throughput

0.437

High

513227

RS8A
Small ribosomal subunit protein eS8A

1

1

High-throughput

0.437

High

514843

RS18A
Small ribosomal subunit protein uS13A

1

1

High-throughput

0.437

High

753593

RS3A1
Small ribosomal subunit protein eS1A

1

2

High-throughput

0.437

High

778540

RS27A
Small ribosomal subunit protein eS27A

1

1

High-throughput

0.437

High

802394

RS20
Small ribosomal subunit protein uS10

1

1

High-throughput

0.437

High

812121

DHH1
ATP-dependent RNA helicase DHH1

1

1

High-throughput

0.437

High

812674

LAA1
AP-1 accessory protein LAA1

1

2

High-throughput

0.437

High

874536

RS12
Small ribosomal subunit protein eS12

1

1

High-throughput

0.437

High

1025043

NUM1
Nuclear migration protein NUM1

1

1

High-throughput

0.437

High

1033575

RS15
Small ribosomal subunit protein uS19

1

3

High-throughput

0.437

High

1054251

VAM6
Vacuolar morphogenesis protein 6

1

1

High-throughput

0.437

High

1054262

RS10A
Small ribosomal subunit protein eS10A

1

6

High-throughput

0.437

High

1054275

RS22B
Small ribosomal subunit protein uS8B

1

3

High-throughput

0.437

High

825563

UTP25
U3 small nucleolar RNA-associated protein 25

1

0

High-throughput

0.426

High

1050235

TAF9
SAGA complex/transcription factor TFIID complex subunit TAF9

1

0

High-throughput

0.426

High

386869

TBB
Tubulin beta chain

1

2

High-throughput

0.407

High

394924

EF1A
Elongation factor 1-alpha

1

1

High-throughput

0.407

High

427452

RLA0
Large ribosomal subunit protein uL10

1

2

High-throughput

0.407

High

453800

PYR1
Multifunctional protein URA2

1

2

High-throughput

0.407

High

790377

STT4
Phosphatidylinositol 4-kinase STT4

1

4

High-throughput

0.407

High

858399

STU2
Protein STU2

1

1

High-throughput

0.407

High

758021

PXA2
Peroxisomal long-chain fatty acid import protein 1

1

0

High-throughput

0.282

High

570149

RL3
Large ribosomal subunit protein uL3

1

0

High-throughput

0.279

Low

383901

RS17A
Small ribosomal subunit protein eS17A

1

0

High-throughput

0.249

Low

795228

NU170
Nucleoporin NUP170

1

0

High-throughput

0.249

Low

918459

EIF2A
Eukaryotic translation initiation factor 2A

1

0

High-throughput

0.249

Low

575523

GFA1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

1

0

High-throughput

0.232

Low

1054258

AVO1
Target of rapamycin complex 2 subunit AVO1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025