HitPredict

Interactor 1: KCNJ2 (P63252)
Inward rectifier potassium channel 2 (Cardiac inward rectifier potassium channel) (Inward rectifier K(+) channel Kir2.1) (IRK-1) (hIRK1) (Potassium channel, inwardly rectifying subfamily J member 2)
Gene: KCNJ2

Interactor 2: SCRIB (Q14160)
Protein scribble homolog (Scribble) (hScrib) (Protein LAP4)
Gene: SCRIB

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	30126976
Identification Methods	p8 filamentous phage display
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0098978 - glutamatergic synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 427 Hs			1 1630
+	Hs
		1049947 KCJ12_HUMAN (2-427): 0: 682: 69.98		SCRIB_HUMAN (1-1630): 0: 978: 100.00
+	Hs
		816149 KCNJ4_HUMAN (30-427): 0: 590: 59.82		SCRIB_HUMAN (1-1630): 0: 978: 100.00
+	Hs
		929762 KCNJ2_HUMAN (1-427): 0: 724: 100.00		DLG4_HUMAN (812-1187): 3.22e-49: 190: 22.42
+	Hs
		942342 KCJ12_HUMAN (2-427): 0: 682: 69.98		DLG4_HUMAN (812-1187): 3.22e-49: 190: 22.42
+	Rn
		677769 KCJ12_RAT (2-427): 0: 668: 70.33		DLG4_RAT (812-1187): 3.08e-49: 190: 22.42
+	Rn
		1144360 KCNJ2_RAT (1-427): 0: 720: 98.83		DLG2_RAT (587-879): 2.66e-21: 103: 18.52
+	Hs
		929764 KCNJ2_HUMAN (1-427): 0: 724: 100.00		DLG1_HUMAN (687-910): 4.67e-15: 82.9: 24.68
+	Rn
		1144015 KCNJ2_RAT (1-427): 0: 720: 98.83		DLG1_RAT (679-910): 1.87e-14: 80.9: 22.79
+	Mm
		852403 KCNJ4_MOUSE (31-427): 0: 601: 59.64		DLG4_MOUSE (812-1187): 6.74e-49: 189: 22.42
+	Hs
		1054723 KCJ12_HUMAN (2-427): 0: 682: 69.98		DLG2_HUMAN (587-879): 1.21e-20: 101: 18.67
+	Hs
		816146 KCNJ4_HUMAN (30-427): 0: 590: 59.82		DLG4_HUMAN (812-1187): 3.22e-49: 190: 22.42
+	Hs
		1054724 KCJ12_HUMAN (2-427): 0: 682: 69.98		DLG3_HUMAN (724-947): 1.74e-19: 97.4: 31.23
+	Mm
		1143540 Q9QYK8_MOUSE (39-421): 0: 587: 59.72		DLG4_MOUSE (812-1187): 6.74e-49: 189: 22.42
+	Rn
		852400 KCJ12_RAT (2-427): 0: 668: 70.33		DLG2_RAT (587-879): 2.66e-21: 103: 18.52
+	Hs
		1021490 KCJ12_HUMAN (2-427): 0: 682: 69.98		DLG1_HUMAN (687-910): 4.67e-15: 82.9: 24.68
+	Rn
		852399 KCJ12_RAT (2-427): 0: 668: 70.33		DLG3_RAT (724-947): 3.57e-19: 96.3: 31.23
+	Hs
		80982 KCJ18_HUMAN (2-427): 0: 675: 69.28		DLG1_HUMAN (687-910): 4.67e-15: 82.9: 24.68
+	Rn
		852397 KCJ12_RAT (2-427): 0: 668: 70.33		DLG1_RAT (679-910): 1.87e-14: 80.9: 22.79
+	Hs
		816150 KCNJ4_HUMAN (30-427): 0: 590: 59.82		DLG2_HUMAN (587-879): 1.21e-20: 101: 18.67
+	Hs
		816147 KCNJ4_HUMAN (30-427): 0: 590: 59.82		DLG1_HUMAN (687-910): 4.67e-15: 82.9: 24.68