Protein: SYYC
Tyrosine--tRNA ligase, cytoplasmic (EC 6.1.1.1) (Tyrosyl-tRNA synthetase) (TyrRS) [Cleaved into: Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed]

Gene: SYYC, YARS1
Organism: Homo sapiens
Interactions: 147
UniProt ID: P54577

Gene Ontology (top 5):
GO:0000049 - tRNA binding
GO:0003723 - RNA binding
GO:0004831 - tyrosine-tRNA ligase activity
GO:0005153 - interleukin-8 receptor binding
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

929762

SYYC
Tyrosine--tRNA ligase, cytoplasmic

1

10

Small-scale

0.647

High

708940

T2EB
Transcription initiation factor IIE subunit beta

2

0

High-throughput

0.602

High

929831

TRIM5
Tripartite motif-containing protein 5

2

0

High-throughput

0.602

High

929767

CDC42
Cell division control protein 42 homolog

2

6

High-throughput

0.595

High

241193

PRKN
E3 ubiquitin-protein ligase parkin

2

4

High-throughput

0.584

High

830408

CCNF
Cyclin-F

2

0

High-throughput

0.576

High

619638

VCAM1
Vascular cell adhesion protein 1

2

1

High-throughput

0.571

High

929763

TERA
Transitional endoplasmic reticulum ATPase

2

3

High-throughput

0.571

High

929787

HAPR1
HUWE1-associated protein modifying stress responses 1

2

0

Small-scale

0.559

High

929845

UBP25
Ubiquitin carboxyl-terminal hydrolase 25

1

1

High-throughput

0.541

High

288076

FOXH1
Forkhead box protein H1

1

4

High-throughput

0.536

High

484452

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

1

High-throughput

0.536

High

929765

FOXL2
Forkhead box protein L2

1

3

High-throughput

0.536

High

929774

2ABA
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

1

1

High-throughput

0.536

High

929779

FOXL1
Forkhead box protein L1

1

3

High-throughput

0.536

High

929799

FOXI2
Forkhead box protein I2

1

3

High-throughput

0.536

High

929826

FOXB1
Forkhead box protein B1

1

4

High-throughput

0.536

High

929830

FOXQ1
Forkhead box protein Q1

1

5

High-throughput

0.536

High

105634

APRIO
Alternative prion protein

2

2

High-throughput

0.533

High

487129

PARP1
Poly [ADP-ribose] polymerase 1

1

5

Small-scale

0.515

High

680684

CATS
Cathepsin S

1

2

High-throughput

0.515

High

929771

ARF6
ADP-ribosylation factor 6

1

2

High-throughput

0.515

High

929786

CBX2
Chromobox protein homolog 2

1

1

High-throughput

0.515

High

929842

MAGC2
Melanoma-associated antigen C2

1

2

High-throughput

0.515

High

929848

CSN3
COP9 signalosome complex subunit 3

1

1

High-throughput

0.515

High

852646

ABCG1
ATP-binding cassette sub-family G member 1

1

0

High-throughput

0.513

High

929824

SORT
Sortilin

1

0

High-throughput

0.513

High

185554

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

2

High-throughput

0.501

High

395752

ESR1
Estrogen receptor

1

1

Small-scale

0.501

High

134619

SAP18
Histone deacetylase complex subunit SAP18

1

0

High-throughput

0.493

High

254567

EIF1B
Eukaryotic translation initiation factor 1b

1

0

High-throughput

0.493

High

929764

IF6
Eukaryotic translation initiation factor 6

1

0

High-throughput

0.493

High

297523

PIAS1
E3 SUMO-protein ligase PIAS1

1

0

High-throughput

0.493

High

600084

ZNF20
Zinc finger protein 20

1

0

High-throughput

0.493

High

929802

ANR23
Ankyrin repeat domain-containing protein 23

1

0

High-throughput

0.493

High

929809

SLN12
Ribonuclease SLFN12

1

0

High-throughput

0.493

High

929810

TCAL8
Transcription elongation factor A protein-like 8

1

0

High-throughput

0.493

High

929815

CEP70
Centrosomal protein of 70 kDa

1

0

High-throughput

0.493

High

929822

ASB9
Ankyrin repeat and SOCS box protein 9

1

0

High-throughput

0.493

High

929828

SPAG8
Sperm-associated antigen 8

1

0

High-throughput

0.493

High

929832

GHITM
Growth hormone-inducible transmembrane protein

1

0

High-throughput

0.493

High

929778

REL
Proto-oncogene c-Rel

1

1

High-throughput

0.481

High

259678

BRD4
Bromodomain-containing protein 4

1

1

High-throughput

0.479

High

293421

CD123
Translation initiation factor eIF2 assembly protein

1

2

High-throughput

0.479

High

330786

KI20A
Kinesin-like protein KIF20A

1

3

High-throughput

0.479

High

352375

TOP3B
DNA topoisomerase 3-beta-1

1

1

High-throughput

0.479

High

389182

FINC
Fibronectin

1

1

High-throughput

0.479

High

411645

NTRK1
High affinity nerve growth factor receptor

1

4

High-throughput

0.479

High

440007

LCK
Tyrosine-protein kinase Lck

1

1

High-throughput

0.479

High

459255

CATL1
Procathepsin L

1

2

High-throughput

0.479

High

460790

CATB
Cathepsin B

1

3

High-throughput

0.479

High

580609

AMPN
Aminopeptidase N

1

2

High-throughput

0.479

High

588298

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.479

High

606494

CEBPB
CCAAT/enhancer-binding protein beta

1

3

High-throughput

0.479

High

621605

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

1

High-throughput

0.479

High

637413

FLNA
Filamin-A

1

1

High-throughput

0.479

High

667679

CDK2
Cyclin-dependent kinase 2

1

1

High-throughput

0.479

High

695026

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

4

High-throughput

0.479

High

711857

LTK
Leukocyte tyrosine kinase receptor

1

4

High-throughput

0.479

High

786038

LONM
Lon protease homolog, mitochondrial

1

4

High-throughput

0.479

High

887864

MCM2
DNA replication licensing factor MCM2

1

1

High-throughput

0.479

High

891397

GSK3B
Glycogen synthase kinase-3 beta

1

3

High-throughput

0.479

High

909989

RND2
Rho-related GTP-binding protein RhoN

1

7

High-throughput

0.479

High

929768

RHOA
Transforming protein RhoA

1

6

High-throughput

0.479

High

929769

WDR5
WD repeat-containing protein 5

1

2

High-throughput

0.479

High

929770

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.479

High

929772

H4
Histone H4

1

1

High-throughput

0.479

High

929773

RAC1
Ras-related C3 botulinum toxin substrate 1

1

6

High-throughput

0.479

High

929780

G3BP1
Ras GTPase-activating protein-binding protein 1

1

1

High-throughput

0.479

High

929781

BIRC3
Baculoviral IAP repeat-containing protein 3

1

3

High-throughput

0.479

High

929782

CUL3
Cullin-3

1

2

High-throughput

0.479

High

929784

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

3

High-throughput

0.479

High

929785

RBM39
RNA-binding protein 39

1

1

High-throughput

0.479

High

929788

TNIP1
TNFAIP3-interacting protein 1

1

2

High-throughput

0.479

High

929789

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

6

High-throughput

0.479

High

929790

KIF14
Kinesin-like protein KIF14

1

1

High-throughput

0.479

High

929791

RHOH
Rho-related GTP-binding protein RhoH

1

7

High-throughput

0.479

High

929792

CCDC6
Coiled-coil domain-containing protein 6

1

1

High-throughput

0.479

High

929800

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.479

High

929801

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

2

High-throughput

0.479

High

929818

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

2

High-throughput

0.479

High

929819

AKAP1
A-kinase anchor protein 1, mitochondrial

1

1

High-throughput

0.479

High

929821

OPTN
Optineurin

1

3

High-throughput

0.479

High

929825

NECD
Necdin

1

2

High-throughput

0.479

High

929827

ANM1
Protein arginine N-methyltransferase 1

1

1

High-throughput

0.479

High

929829

ACE2
Angiotensin-converting enzyme 2

1

1

High-throughput

0.479

High

929834

PKHA4
Pleckstrin homology domain-containing family A member 4

1

5

High-throughput

0.479

High

929835

WDR76
WD repeat-containing protein 76

1

4

High-throughput

0.479

High

929836

RHOF
Rho-related GTP-binding protein RhoF

1

8

High-throughput

0.479

High

929837

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

1

High-throughput

0.479

High

929839

ANLN
Anillin

1

2

High-throughput

0.479

High

929840

TMPS4
Transmembrane protease serine 4

1

3

High-throughput

0.479

High

929841

DYH1
Dynein axonemal heavy chain 1

1

1

High-throughput

0.479

High

929843

TRM7
tRNA

1

2

High-throughput

0.479

High

929844

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

929846

ANC2
Anaphase-promoting complex subunit 2

1

3

High-throughput

0.479

High

929850

FND3A
Fibronectin type-III domain-containing protein 3A

1

2

High-throughput

0.479

High

929851

TRAF6
TNF receptor-associated factor 6

1

2

High-throughput

0.479

High

774230

BASI
Basigin

1

1

High-throughput

0.470

High

929796

CD158
Coiled-coil domain-containing protein 158

1

1

High-throughput

0.470

High

929798

S27A4
Long-chain fatty acid transport protein 4

1

3

High-throughput

0.470

High

929805

Q86V28
AP-1 complex subunit gamma

1

1

High-throughput

0.470

High

164291

NRP1
Neuropilin-1

1

0

High-throughput

0.458

High

349894

SNAI1
Zinc finger protein SNAI1

1

0

High-throughput

0.458

High

363027

EGFR
Epidermal growth factor receptor

1

0

High-throughput

0.458

High

426462

HMGN2
Non-histone chromosomal protein HMG-17

1

0

High-throughput

0.458

High

473880

NFIC
Nuclear factor 1 C-type

1

0

High-throughput

0.458

High

799817

COIL
Coilin

1

0

High-throughput

0.458

High

929766

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

0

High-throughput

0.458

High

929775

HSF1
Heat shock factor protein 1

1

0

High-throughput

0.458

High

929783

APR
Phorbol-12-myristate-13-acetate-induced protein 1

1

0

High-throughput

0.458

High

929794

CPEB4
Cytoplasmic polyadenylation element-binding protein 4

1

0

High-throughput

0.458

High

929797

TET5C
Terminal nucleotidyltransferase 5C

1

0

High-throughput

0.458

High

929807

DYR2
Dihydrofolate reductase 2, mitochondrial

1

0

High-throughput

0.458

High

929811

RHG24
Rho GTPase-activating protein 24

1

0

High-throughput

0.458

High

929814

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.458

High

929820

CHM4C
Charged multivesicular body protein 4c

1

0

High-throughput

0.458

High

929838

DCP1A
mRNA-decapping enzyme 1A

1

0

High-throughput

0.458

High

354614

PAK4
Serine/threonine-protein kinase PAK 4

1

1

High-throughput

0.445

High

429580

JUN
Transcription factor Jun

1

6

High-throughput

0.445

High

529413

TAU
Microtubule-associated protein tau

1

1

High-throughput

0.445

High

929795

KLH22
Kelch-like protein 22

1

1

High-throughput

0.445

High

929849

GAB2
GRB2-associated-binding protein 2

1

4

High-throughput

0.445

High

188845

TMPS2
Transmembrane protease serine 2

1

3

High-throughput

0.437

High

560341

IFM1
Interferon-induced transmembrane protein 1

1

3

High-throughput

0.437

High

565253

ITA4
Integrin alpha-4

1

1

High-throughput

0.437

High

692898

DPP4
Dipeptidyl peptidase 4

1

2

High-throughput

0.437

High

767786

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.437

High

878833

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

3

High-throughput

0.437

High

929776

IFM3
Interferon-induced transmembrane protein 3

1

3

High-throughput

0.437

High

929793

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

3

High-throughput

0.437

High

929803

TM11B
Transmembrane protease serine 11B

1

3

High-throughput

0.437

High

929804

RM52
Large ribosomal subunit protein mL52

1

1

High-throughput

0.437

High

929817

CLC4D
C-type lectin domain family 4 member D

1

3

High-throughput

0.437

High

929833

RHOJ
Rho-related GTP-binding protein RhoJ

1

6

High-throughput

0.437

High

929847

CLC4E
C-type lectin domain family 4 member E

1

3

High-throughput

0.437

High

929777

TAGL
Transgelin

1

0

High-throughput

0.426

High

929808

TM192
Transmembrane protein 192

1

0

High-throughput

0.279

Low

789616

HPCL1
Hippocalcin-like protein 1

1

0

High-throughput

0.268

Low

929813

PACRL
PACRG-like protein

1

0

High-throughput

0.268

Low

929816

ATLA1
Atlastin-1

1

0

High-throughput

0.268

Low

488754

FURIN
Furin

1

0

High-throughput

0.249

Low

929812

ANR35
Ankyrin repeat domain-containing protein 35

1

0

High-throughput

0.249

Low

62480

S35F4
Solute carrier family 35 member F4

1

0

High-throughput

0.232

Low

929806

S2611
Sodium-independent sulfate anion transporter

1

0

High-throughput

0.232

Low

929823

S41A3
Solute carrier family 41 member 3

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025