HitPredict

Interactor 1: ACTG (P63261)
Actin, cytoplasmic 2 (EC 3.6.4.-) (Gamma-actin) [Cleaved into: Actin, cytoplasmic 2, N-terminally processed]
Gene: ACTG1

Interactor 2: DREB (Q16643)
Drebrin (Developmentally-regulated brain protein)
Gene: DBN1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	26496610, 37071682
Identification Methods	affinity chromatography technology, cross-linking study, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Actin~Cofilin_ADF
Common GO terms	GO:0005522 - profilin binding GO:0005737 - cytoplasm GO:0005856 - cytoskeleton GO:0005884 - actin filament
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 375 Hs			1 649
+	Hs
		1084964 ACTBL_HUMAN (2-375): 0: 734: 91.44		DREB_HUMAN (1-649): 5.59e-95: 307: 100.00
+	Hs
		891799 ACTB_HUMAN (1-375): 0: 604: 98.93		DREB_HUMAN (1-649): 5.59e-95: 307: 100.00
+	Hs
		932187 ACTC_HUMAN (2-375): 0: 595: 94.39		DREB_HUMAN (1-649): 5.59e-95: 307: 100.00
+	Hs
		915391 ACTA_HUMAN (2-375): 0: 594: 94.39		DREB_HUMAN (1-649): 5.59e-95: 307: 100.00
+	Hs
		892099 ACTB_HUMAN (1-375): 0: 604: 98.93		DBNL_HUMAN (3-464): 1.68e-73: 244: 29.98
+	Hs
		932439 ACTC_HUMAN (2-375): 0: 595: 94.39		DBNL_HUMAN (3-464): 1.68e-73: 244: 29.98
+	Ce
		501469 ACT2_CAEEL (2-375): 0: 602: 97.06		Q9XUT0_CAEEL (4-564): 1.01e-44: 171: 16.98
+	Hs
		891932 ACTB_HUMAN (1-375): 0: 604: 98.93		CTTB2_HUMAN (131-644): 3.31e-33: 139: 14.55
+	Sc
		551386 ACT_YEAST (1-375): 0: 592: 89.07		ABP1_YEAST (4-508): 1.78e-30: 128: 13.51
+	Dm
		950123 ACT6_DROME (2-375): 0: 596: 95.46		TITIN_DROME (173-542): 1.72e-27: 121: 13.80
+	Dm
		54871 ACT6_DROME (2-375): 0: 596: 95.46		A1ZA72_DROME (119-642): 1.06e-09: 64.1: 10.13
+	Hs
		203220 ACTC_HUMAN (2-375): 0: 595: 94.39		SYNJ1_HUMAN (103-518): 1.79e-09: 63.3: 9.35