HitPredict

Interactor 1: ACTG (P63261)
Actin, cytoplasmic 2 (EC 3.6.4.-) (Gamma-actin) [Cleaved into: Actin, cytoplasmic 2, N-terminally processed]
Gene: ACTG1

Interactor 2: SH3G2 (Q99962)
Endophilin-A1 (EEN-B1) (Endophilin-1) (SH3 domain protein 2A) (SH3 domain-containing GRB2-like protein 2)
Gene: SH3GL2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.60	0.541

Property	Details
Experiments	16169070
Identification Methods	two hybrid, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 375 Hs			1 352
+	Ce
		70025 ACT4_CAEEL (2-375): 0: 602: 97.06		SH3GH_CAEEL (1-350): 5e-70: 225: 43.19
+	Hs
		891762 ACTB_HUMAN (1-375): 0: 604: 98.93		SRC8_HUMAN (7-348): 9.8e-53: 184: 14.83
+	Hs
		929863 ACTG_HUMAN (1-375): 0: 604: 100.00		SRC8_HUMAN (7-348): 9.8e-53: 184: 14.83
+	Hs
		932154 ACTC_HUMAN (2-375): 0: 595: 94.39		SRC8_HUMAN (7-348): 9.8e-53: 184: 14.83
+	Hs
		891832 ACTB_HUMAN (1-375): 0: 604: 98.93		RHG17_HUMAN (6-256): 5.79e-38: 146: 21.56
+	Hs
		891755 ACTB_HUMAN (1-375): 0: 604: 98.93		SPTN1_HUMAN (4-349): 7.57e-37: 143: 16.06
+	Hs
		929856 ACTG_HUMAN (1-375): 0: 604: 100.00		SPTN1_HUMAN (4-349): 7.57e-37: 143: 16.06
+	Hs
		596202 ACTB_HUMAN (1-375): 0: 604: 98.93		NEBU_HUMAN (7-347): 1.26e-36: 142: 16.34
+	Dm
		501483 ACT1_DROME (2-375): 0: 600: 98.13		SPTCA_DROME (1-348): 2.77e-36: 141: 13.60
+	Dm
		361136 ACT2_DROME (2-375): 0: 598: 97.59		SPTCA_DROME (1-348): 2.77e-36: 141: 13.60
+	Dm
		501441 ACT5_DROME (2-375): 0: 598: 95.46		SPTCA_DROME (1-348): 2.77e-36: 141: 13.60
+	Hs
		932145 ACTC_HUMAN (2-375): 0: 595: 94.39		SPTN1_HUMAN (4-349): 7.57e-37: 143: 16.06
+	Dm
		527089 ACT3_DROME (2-375): 0: 596: 94.92		SPTCA_DROME (1-348): 2.77e-36: 141: 13.60
+	Dm
		527091 ACT6_DROME (2-375): 0: 596: 95.46		SPTCA_DROME (1-348): 2.77e-36: 141: 13.60
+	Hs
		932975 ACTS_HUMAN (2-375): 0: 594: 93.85		SPTN1_HUMAN (4-349): 7.57e-37: 143: 16.06
+	Hs
		891671 ACTB_HUMAN (1-375): 0: 604: 98.93		GRB2_HUMAN (295-351): 1.51e-12: 67.8: 43.10
+	Hs
		924453 ACTG_HUMAN (1-375): 0: 604: 100.00		GRB2_HUMAN (295-351): 1.51e-12: 67.8: 43.10
+	Hs
		891821 ACTB_HUMAN (1-375): 0: 604: 98.93		SH319_HUMAN (296-347): 6.75e-10: 62.4: 55.77
+	Hs
		891945 ACTB_HUMAN (1-375): 0: 604: 98.93		OSTF1_HUMAN (296-344): 1.44e-09: 59.3: 53.06
+	Hs
		924456 ACTC_HUMAN (2-375): 0: 595: 94.39		GRB2_HUMAN (295-351): 1.51e-12: 67.8: 43.10