HitPredict

Interactor 1: ACTG (P63261)
Actin, cytoplasmic 2 (EC 3.6.4.-) (Gamma-actin) [Cleaved into: Actin, cytoplasmic 2, N-terminally processed]
Gene: ACTG1

Interactor 2: TMOD2 (Q9NZR1)
Tropomodulin-2 (Neuronal tropomodulin) (N-Tmod)
Gene: TMOD2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	35271311, 37071682
Identification Methods	affinity chromatography technology, cross-linking study, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Actin~Tropomodulin
Common GO terms	GO:0005856 - cytoskeleton GO:0030016 - myofibril GO:0045202 - synapse
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 375 Hs			1 351
+	Hs
		1122520 ACTBL_HUMAN (2-375): 0: 734: 91.44		TMOD3_HUMAN (1-351): 1.22e-126: 369: 75.85
+	Hs
		892077 ACTB_HUMAN (1-375): 0: 604: 98.93		TMOD2_HUMAN (1-351): 3.19e-129: 375: 100.00
+	Hs
		892073 ACTB_HUMAN (1-375): 0: 604: 98.93		TMOD3_HUMAN (1-351): 1.22e-126: 369: 75.85
+	Hs
		932417 ACTC_HUMAN (2-375): 0: 595: 94.39		TMOD2_HUMAN (1-351): 3.19e-129: 375: 100.00
+	Hs
		932411 ACTC_HUMAN (2-375): 0: 595: 94.39		TMOD3_HUMAN (1-351): 1.22e-126: 369: 75.85
+	Hs
		915520 ACTA_HUMAN (2-375): 0: 594: 94.39		TMOD3_HUMAN (1-351): 1.22e-126: 369: 75.85
+	Hs
		657477 ACTB_HUMAN (1-375): 0: 604: 98.93		TMOD1_HUMAN (3-346): 2.23e-115: 340: 59.71
+	Hs
		657481 ACTG_HUMAN (1-375): 0: 604: 100.00		TMOD1_HUMAN (3-346): 2.23e-115: 340: 59.71
+	Hs
		657479 ACTA_HUMAN (2-375): 0: 594: 94.39		TMOD1_HUMAN (3-346): 2.23e-115: 340: 59.71
+	Mm
		1206347 ACTBL_MOUSE (1-375): 0: 741: 92.27		NLRP3_MOUSE (175-335): 1.18e-28: 119: 16.36
+	Hs
		932227 ACTC_HUMAN (2-375): 0: 595: 94.39		NLRC3_HUMAN (118-348): 1.25e-34: 136: 17.31
+	Hs
		886390 ACTB_HUMAN (1-375): 0: 604: 98.93		NAL12_HUMAN (183-335): 6.94e-23: 102: 17.20