HitPredict

Interactor 1: PP2AA (P67775)
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PP2A-alpha) (EC 3.1.3.16) (Replication protein C) (RP-C)
Gene: PPP2CA

Interactor 2: M4K3 (Q8IVH8)
Mitogen-activated protein kinase kinase kinase kinase 3 (EC 2.7.11.1) (Germinal center kinase-related protein kinase) (GLK) (MAPK/ERK kinase kinase kinase 3) (MEK kinase kinase 3) (MEKKK 3)
Gene: MAP4K3

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	32640226
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0035556 - intracellular signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 309 Hs			1 894
+	Hs
		930942 PP2AA_HUMAN (1-309): 0: 529: 100.00		M4K1_HUMAN (6-893): 0: 782: 39.19
+	Hs
		647866 PP2AB_HUMAN (1-309): 0: 528: 97.41		MARK3_HUMAN (9-622): 2.54e-141: 439: 16.67
+	Hs
		915261 PP2AB_HUMAN (1-309): 0: 528: 97.41		MARK4_HUMAN (7-596): 6.07e-135: 422: 18.23
+	Hs
		681777 PP2AA_HUMAN (1-309): 0: 529: 100.00		AKT1_HUMAN (6-341): 6.7e-134: 410: 23.70
+	Mm
		682104 PP2AA_MOUSE (1-309): 0: 528: 99.68		AKT1_MOUSE (6-341): 3.93e-134: 411: 23.41
+	Hs
		682162 PP2AA_HUMAN (1-309): 0: 529: 100.00		AKT2_HUMAN (5-344): 8.04e-134: 410: 22.92
+	Hs
		931045 PP2AA_HUMAN (1-309): 0: 529: 100.00		AKT3_HUMAN (1-344): 1.23e-133: 410: 23.10
+	Hs
		930835 PP2AA_HUMAN (1-309): 0: 529: 100.00		KCC2B_HUMAN (14-543): 1.02e-128: 404: 19.07
+	Hs
		915182 PP2AB_HUMAN (1-309): 0: 528: 97.41		KCC2B_HUMAN (14-543): 1.02e-128: 404: 19.07
+	Dm
		619883 PP2A_DROME (1-309): 0: 524: 93.85		AKT1_DROME (9-346): 6.87e-130: 405: 24.28
+	Hs
		931026 PP2AA_HUMAN (1-309): 0: 529: 100.00		STK26_HUMAN (3-291): 7.94e-118: 366: 46.05
+	Hs
		915296 PP2AB_HUMAN (1-309): 0: 528: 97.41		STK26_HUMAN (3-291): 7.94e-118: 366: 46.05
+	Hs
		131564 PP2AA_HUMAN (1-309): 0: 529: 100.00		STK25_HUMAN (8-372): 1.06e-116: 364: 40.46
+	Hs
		131561 PP2AB_HUMAN (1-309): 0: 528: 97.41		STK25_HUMAN (8-372): 1.06e-116: 364: 40.46
+	Hs
		931059 PP2AA_HUMAN (1-309): 0: 529: 100.00		STK24_HUMAN (9-291): 7.65e-116: 362: 46.67
+	Hs
		915317 PP2AB_HUMAN (1-309): 0: 528: 97.41		STK24_HUMAN (9-291): 7.65e-116: 362: 46.67
+	Mm
		915321 PP2AB_MOUSE (1-309): 0: 528: 97.41		TNIK_MOUSE (6-290): 5.69e-73: 264: 48.32
+	Hs
		324785 PP2AA_HUMAN (1-309): 0: 529: 100.00		M4K4_HUMAN (8-290): 6.77e-67: 245: 47.28
+	Hs
		324775 PP2AB_HUMAN (1-309): 0: 528: 97.41		M4K4_HUMAN (8-290): 6.77e-67: 245: 47.28
+	Hs
		91409 PP2AB_HUMAN (1-309): 0: 528: 97.41		E7EN19_HUMAN (8-290): 1.31e-66: 244: 47.28