HitPredict

Interactor 1: UB2L3 (P68037)
Ubiquitin-conjugating enzyme E2 L3 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme L3) (UbcM4) (Ubiquitin carrier protein L3) (Ubiquitin-protein ligase L3)
Gene: Ube2l3

Interactor 2: WWP2 (Q9DBH0)
NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase WWP2) (WW domain-containing protein 2)
Gene: WWP2

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	21170031
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	HECT~UQ_con
Common GO terms	GO:0004842 - ubiquitin-protein transferase activity GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0016567 - protein ubiquitination
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 154 Mm			1 870
+	Hs
		125808 UB2D4_HUMAN (2-149): 6.75e-76: 224: 38.93		WWP2_HUMAN (1-870): 0: 956: 95.98
+	Hs
		125262 UB2D1_HUMAN (2-149): 5.66e-75: 221: 38.26		WWP2_HUMAN (1-870): 0: 956: 95.98
+	Hs
		125335 UB2D2_HUMAN (2-149): 7.95e-75: 221: 37.58		WWP2_HUMAN (1-870): 0: 956: 95.98
+	Hs
		1294888 UB2D4_HUMAN (2-149): 6.75e-76: 224: 38.93		ITCH_HUMAN (1-870): 0: 882: 55.29
+	Hs
		849411 UB2D1_HUMAN (2-149): 5.66e-75: 221: 38.26		ITCH_HUMAN (1-870): 0: 882: 55.29
+	Hs
		919827 UB2D2_HUMAN (2-149): 7.95e-75: 221: 37.58		ITCH_HUMAN (1-870): 0: 882: 55.29
+	Hs
		919860 UB2D2_HUMAN (2-149): 7.95e-75: 221: 37.58		WWP1_HUMAN (1-870): 0: 872: 57.19
+	Hs
		849416 UB2D1_HUMAN (2-149): 5.66e-75: 221: 38.26		NED4L_HUMAN (5-867): 0: 802: 31.84
+	Hs
		919834 UB2D2_HUMAN (2-149): 7.95e-75: 221: 37.58		NED4L_HUMAN (5-867): 0: 802: 31.84
+	Hs
		808052 UB2D1_HUMAN (2-149): 5.66e-75: 221: 38.26		NEDD4_HUMAN (90-868): 0: 744: 35.87
+	Hs
		808078 UB2D2_HUMAN (2-149): 7.95e-75: 221: 37.58		NEDD4_HUMAN (90-868): 0: 744: 35.87
+	Hs
		849353 UB2D1_HUMAN (2-149): 5.66e-75: 221: 38.26		HUWE1_HUMAN (95-869): 6.41e-178: 572: 25.66
+	Hs
		919765 UB2D2_HUMAN (2-149): 7.95e-75: 221: 37.58		HUWE1_HUMAN (95-869): 6.41e-178: 572: 25.66
+	Hs
		919782 UB2D2_HUMAN (2-149): 7.95e-75: 221: 37.58		HACE1_HUMAN (386-864): 2.14e-168: 514: 31.77
+	Hs
		919867 UB2D2_HUMAN (2-149): 7.95e-75: 221: 37.58		SMUF2_HUMAN (1-366): 7.32e-49: 187: 20.00
+	Hs
		919869 UB2D2_HUMAN (2-149): 7.95e-75: 221: 37.58		SMUF1_HUMAN (1-387): 2.24e-39: 158: 16.90
+	Sc
		549815 UBC4_YEAST (1-148): 8.58e-75: 221: 40.27		RSP5_YEAST (16-373): 1.07e-36: 150: 18.24
+	Hs
		919889 UB2D2_HUMAN (2-149): 7.95e-75: 221: 37.58		HECW2_HUMAN (89-526): 3.12e-17: 89.1: 17.36
+	Hs
		849351 UB2D1_HUMAN (2-149): 5.66e-75: 221: 38.26		HECW1_HUMAN (215-535): 8.91e-14: 77.9: 16.53
+	Hs
		919762 UB2D2_HUMAN (2-149): 7.95e-75: 221: 37.58		HECW1_HUMAN (215-535): 8.91e-14: 77.9: 16.53