Protein: PTN9
Tyrosine-protein phosphatase non-receptor type 9 (EC 3.1.3.48) (Protein-tyrosine phosphatase MEG2) (PTPase MEG2)

Gene: PTN9, PTPN9
Organism: Homo sapiens
Interactions: 99
UniProt ID: P43378

Gene Ontology (top 5):
GO:0004725 - protein tyrosine phosphatase activity
GO:0004726 - non-membrane spanning protein tyrosine phosphatase activity
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0006470 - protein dephosphorylation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

533836

GHR
Growth hormone receptor

1

20

Small-scale

0.669

High

328873

RTN3
Reticulon-3

5

4

High-throughput

0.659

High

849009

ATRAP
Type-1 angiotensin II receptor-associated protein

5

1

High-throughput

0.657

High

849029

CKLF5
CKLF-like MARVEL transmembrane domain-containing protein 5

4

1

High-throughput

0.642

High

640576

MK
Midkine

2

4

High-throughput

0.628

High

849032

EYA1
Protein phosphatase EYA1

2

2

High-throughput

0.628

High

849033

TTPAL
Alpha-tocopherol transfer protein-like

1

1

High-throughput

0.618

High

848987

PTN9
Tyrosine-protein phosphatase non-receptor type 9

1

18

High-throughput

0.618

High

849010

TRI67
Tripartite motif-containing protein 67

1

10

High-throughput

0.618

High

849019

LZTR1
Leucine-zipper-like transcriptional regulator 1

3

1

High-throughput

0.609

High

849020

TM86B
Lysoplasmalogenase TMEM86B

2

1

High-throughput

0.606

High

849022

DHB11
Estradiol 17-beta-dehydrogenase 11

2

4

High-throughput

0.606

High

849028

CR3L1
Cyclic AMP-responsive element-binding protein 3-like protein 1

2

3

High-throughput

0.606

High

849040

SPAG4
Sperm-associated antigen 4 protein

2

1

High-throughput

0.606

High

219068

RA51C
DNA repair protein RAD51 homolog 3

2

0

High-throughput

0.602

High

849031

REEP6
Receptor expression-enhancing protein 6

3

2

High-throughput

0.597

High

230279

CREB3
Cyclic AMP-responsive element-binding protein 3

2

1

High-throughput

0.590

High

848991

TERA
Transitional endoplasmic reticulum ATPase

2

4

High-throughput

0.584

High

253062

PLIN3
Perilipin-3

2

0

High-throughput

0.580

High

849007

GORAB
RAB6-interacting golgin

2

0

High-throughput

0.580

High

849001

PDCD1
Programmed cell death protein 1

2

1

High-throughput

0.574

High

849045

C5AR2
C5a anaphylatoxin chemotactic receptor 2

2

19

High-throughput

0.574

High

849026

MAL2
Protein MAL2

2

2

High-throughput

0.573

High

325526

YIF1A
Protein YIF1A

2

1

High-throughput

0.553

High

464682

CXB1
Gap junction beta-1 protein

2

6

High-throughput

0.553

High

722411

CTR1
High affinity cationic amino acid transporter 1

2

2

High-throughput

0.553

High

848998

AQP6
Aquaporin-6

2

1

High-throughput

0.553

High

849004

AR13B
ADP-ribosylation factor-like protein 13B

2

6

High-throughput

0.553

High

849011

MOT13
Monocarboxylate transporter 13

2

5

High-throughput

0.553

High

849013

DHB13
17-beta-hydroxysteroid dehydrogenase 13

2

4

High-throughput

0.553

High

849016

ZNT8
Proton-coupled zinc antiporter SLC30A8

2

4

High-throughput

0.553

High

849018

CKLF4
CKLF-like MARVEL transmembrane domain-containing protein 4

2

4

High-throughput

0.553

High

849024

BSND
Barttin

2

1

High-throughput

0.553

High

849030

TMM80
Transmembrane protein 80

2

2

High-throughput

0.553

High

849034

DERL2
Derlin-2

2

3

High-throughput

0.553

High

849039

CERS4
Ceramide synthase 4

2

4

High-throughput

0.553

High

849050

TMX2
Thioredoxin-related transmembrane protein 2

2

2

High-throughput

0.553

High

849054

FKBP7
Peptidyl-prolyl cis-trans isomerase FKBP7

2

2

High-throughput

0.553

High

411533

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.553

High

835472

CCR2
C-C chemokine receptor type 2

1

13

High-throughput

0.541

High

849052

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

1

High-throughput

0.536

High

849053

CERT
Ceramide transfer protein

1

5

High-throughput

0.536

High

547106

PYC
Pyruvate carboxylase, mitochondrial

1

0

High-throughput

0.513

High

848997

MTM1
Myotubularin

1

0

High-throughput

0.513

High

848988

NSF
Vesicle-fusing ATPase

1

12

Small-scale

0.489

High

385531

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

7

High-throughput

0.481

High

128171

PSD12
26S proteasome non-ATPase regulatory subunit 12

1

9

High-throughput

0.479

High

240998

PRKN
E3 ubiquitin-protein ligase parkin

1

3

High-throughput

0.479

High

403900

GCR
Glucocorticoid receptor

1

5

High-throughput

0.479

High

588122

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.479

High

694842

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

4

High-throughput

0.479

High

767617

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.479

High

830292

CCNF
Cyclin-F

1

2

High-throughput

0.479

High

848989

VAMP7
Vesicle-associated membrane protein 7

1

3

Small-scale

0.479

High

849003

SMN
Survival motor neuron protein

1

1

High-throughput

0.479

High

849005

PP6R3
Serine/threonine-protein phosphatase 6 regulatory subunit 3

1

1

High-throughput

0.479

High

849017

ANKH1
Ankyrin repeat and KH domain-containing protein 1

1

3

High-throughput

0.479

High

849023

RN149
E3 ubiquitin-protein ligase RNF149

1

12

High-throughput

0.479

High

849025

S39A7
Zinc transporter SLC39A7

1

12

High-throughput

0.479

High

849036

PKHA4
Pleckstrin homology domain-containing family A member 4

1

17

High-throughput

0.479

High

849047

DDX20
Probable ATP-dependent RNA helicase DDX20

1

3

High-throughput

0.479

High

849051

STRAP
Serine-threonine kinase receptor-associated protein

1

2

High-throughput

0.479

High

849027

Q96AL5
PBX3 protein

1

1

High-throughput

0.470

High

848992

GEMI4
Gem-associated protein 4

1

0

High-throughput

0.458

High

848995

TP53B
TP53-binding protein 1

1

0

High-throughput

0.458

High

849038

QTRT2
Queuine tRNA-ribosyltransferase accessory subunit 2

1

0

High-throughput

0.458

High

849042

GEMI8
Gem-associated protein 8

1

0

High-throughput

0.458

High

849043

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

848996

GAB1
GRB2-associated-binding protein 1

1

10

High-throughput

0.445

High

823928

PBX3
Pre-B-cell leukemia transcription factor 3

1

1

High-throughput

0.439

High

189448

STX7
Syntaxin-7

1

6

Small-scale

0.437

High

630715

RAB4A
Ras-related protein Rab-4A

1

5

High-throughput

0.437

High

731051

STIP1
Stress-induced-phosphoprotein 1

1

1

High-throughput

0.437

High

848994

MPPA
Mitochondrial-processing peptidase subunit alpha

1

2

High-throughput

0.437

High

848999

RCN2
Reticulocalbin-2

1

3

High-throughput

0.437

High

849008

LTOR1
Ragulator complex protein LAMTOR1

1

3

High-throughput

0.437

High

849012

ATG9A
Autophagy-related protein 9A

1

1

High-throughput

0.437

High

849037

TMT1A
Thiol S-methyltransferase TMT1A

1

2

High-throughput

0.437

High

849046

VTI1B
Vesicle transport through interaction with t-SNAREs homolog 1B

1

1

Small-scale

0.437

High

849048

STX8
Syntaxin-8

1

1

Small-scale

0.437

High

516651

VSIG8
V-set and immunoglobulin domain-containing protein 8

1

9

High-throughput

0.407

High

129856

GET1
Guided entry of tail-anchored proteins factor 1

2

0

High-throughput

0.316

High

142085

PEX12
Peroxisome assembly protein 12

2

0

High-throughput

0.316

High

178734

SCAM1
Secretory carrier-associated membrane protein 1

2

0

High-throughput

0.316

High

469469

SYPH
Synaptophysin

2

0

High-throughput

0.316

High

617485

ATP5J
ATP synthase peripheral stalk subunit F6, mitochondrial

2

0

High-throughput

0.316

High

848990

CDR1
Cerebellar degeneration-related antigen 1

2

0

High-throughput

0.316

High

849000

AR6P1
ADP-ribosylation factor-like protein 6-interacting protein 1

2

0

High-throughput

0.316

High

849002

EBP
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase

2

0

High-throughput

0.316

High

849014

TMCO2
Transmembrane and coiled-coil domain-containing protein 2

2

0

High-throughput

0.316

High

849015

CPLX4
Complexin-4

2

0

High-throughput

0.316

High

849035

LIME1
Lck-interacting transmembrane adapter 1

2

0

High-throughput

0.316

High

849041

F1142
Protein FAM114A2

2

0

High-throughput

0.316

High

849044

COQ3
Ubiquinone biosynthesis O-methyltransferase, mitochondrial

2

0

High-throughput

0.316

High

849006

CAHM4
Calcium homeostasis modulator protein 4

1

0

High-throughput

0.279

Low

848993

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.249

Low

849021

FSIP1
Fibrous sheath-interacting protein 1

1

0

High-throughput

0.249

Low

849049

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025