HitPredict

Interactor 1: SET1A (E9PYH6)
Histone-lysine N-methyltransferase SETD1A (EC 2.1.1.364) (SET domain-containing protein 1A)
Gene: Setd1a

Interactor 2: H33 (P84244)
Histone H3.3
Gene: H3-3a

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	24368734
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Histone~N-SET, Histone~SET
Common GO terms	GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1716 Mm			1 136
+	Hs
		165661 SET1A_HUMAN (1-1716): 3.94e-175: 576: 87.76		H31_HUMAN (1-136): 3.08e-60: 183: 96.32
+	Hs
		165688 SET1A_HUMAN (1-1716): 3.94e-175: 576: 87.76		H32_HUMAN (1-136): 5.32e-59: 180: 97.06
+	Hs
		934681 KMT2A_HUMAN (1257-1716): 1.31e-76: 285: 26.21		H31_HUMAN (1-136): 3.08e-60: 183: 96.32
+	Hs
		952284 KMT2A_HUMAN (1257-1716): 1.31e-76: 285: 26.21		H33_HUMAN (1-136): 1.12e-59: 182: 100.00
+	Hs
		975268 KMT2A_HUMAN (1257-1716): 1.31e-76: 285: 26.21		H31T_HUMAN (1-136): 2.58e-59: 181: 93.38
+	Hs
		975278 KMT2A_HUMAN (1257-1716): 1.31e-76: 285: 26.21		H32_HUMAN (1-136): 5.32e-59: 180: 97.06
+	Hs
		935251 EHMT1_HUMAN (623-1714): 1.02e-73: 273: 13.78		H31_HUMAN (1-136): 3.08e-60: 183: 96.32
+	Hs
		952633 EHMT1_HUMAN (623-1714): 1.02e-73: 273: 13.78		H33_HUMAN (1-136): 1.12e-59: 182: 100.00
+	Hs
		1086320 EHMT1_HUMAN (623-1714): 1.02e-73: 273: 13.78		H31T_HUMAN (1-136): 2.58e-59: 181: 93.38
+	Dm
		356072 EZ_DROME (1148-1696): 3.74e-74: 266: 14.59		H3_DROME (1-136): 5.32e-59: 180: 97.06
+	Mm
		952754 Q6AXH7_MOUSE (1219-1699): 1.35e-72: 261: 17.36		H33_MOUSE (1-136): 1.12e-59: 182: 100.00
+	Mm
		952747 EZH2_MOUSE (1219-1699): 3.22e-72: 260: 17.52		H33_MOUSE (1-136): 1.12e-59: 182: 100.00
+	Sp
		457194 SET1_SCHPO (1120-1716): 2.3e-72: 264: 24.79		H31_SCHPO (1-136): 1.12e-57: 177: 91.91
+	Hs
		934804 EZH2_HUMAN (1207-1699): 8.8e-72: 258: 17.53		H31_HUMAN (1-136): 3.08e-60: 183: 96.32
+	Hs
		952363 EZH2_HUMAN (1207-1699): 8.8e-72: 258: 17.53		H33_HUMAN (1-136): 1.12e-59: 182: 100.00
+	Hs
		1079993 EZH2_HUMAN (1207-1699): 8.8e-72: 258: 17.53		H31T_HUMAN (1-136): 2.58e-59: 181: 93.38
+	Hs
		1080038 EZH2_HUMAN (1207-1699): 8.8e-72: 258: 17.53		H3C_HUMAN (1-136): 1.99e-56: 173: 95.59
+	Hs
		828202 KMT2A_HUMAN (1257-1716): 1.31e-76: 285: 26.21		CENPA_HUMAN (9-133): 2.42e-45: 146: 50.76
+	Sc
		755791 SET1_YEAST (1304-1716): 4.49e-69: 256: 26.71		H3_YEAST (1-136): 3.62e-54: 168: 90.44
+	Hs
		828381 EHMT1_HUMAN (623-1714): 1.02e-73: 273: 13.78		CENPA_HUMAN (9-133): 2.42e-45: 146: 50.76