Interactor 1: RYR2 (E9Q401)
Ryanodine receptor 2 (RYR-2) (RyR2) (Cardiac muscle ryanodine receptor) (Cardiac muscle ryanodine receptor-calcium release channel) (Type 2 ryanodine receptor)
Gene: RYR2

Interactor 2: CAC1C (Q01815)
Voltage-dependent L-type calcium channel subunit alpha-1C (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle) (MELC-CC) (Mouse brain class C) (MBC) (Voltage-gated calcium channel subunit alpha Cav1.2)
Gene: Cacna1c

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.54 1.00 0.737

The method score is based on:

Property Details
Experiments 16352659, 24952909
Identification Methods affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains Ca_chan_IQ~EF-hand_7, EF-hand_7~Ion_trans, Ion_trans~Ion_trans, Ion_trans~RR_TM4-6
Common GO terms GO:0005516 - calmodulin binding
GO:0006816 - calcium ion transport
GO:0006874 - intracellular calcium ion homeostasis
GO:0010881 - regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
GO:0016020 - membrane
and 7 others

more...

Homologous interactions 10

Homologous interactions

Color coding for hit scores

1 4966
Mm

1 2139
+ Hs
+ Hs
+ Oc
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs

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Last updated: 15 Jul 2024