Protein: IF2A
Eukaryotic translation initiation factor 2 subunit alpha (eIF-2-alpha) (eIF-2A) (eIF-2alpha) (eIF2-alpha)

Gene: IF2A, SUI2
Organism: Saccharomyces cerevisiae S288C
Interactions: 117
UniProt ID: P20459

Gene Ontology (top 5):
GO:0001731 - formation of translation preinitiation complex
GO:0003723 - RNA binding
GO:0003743 - translation initiation factor activity
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

632868

IF2G
Eukaryotic translation initiation factor 2 subunit gamma

15

8

Small-scale

0.986

High

555288

EI2BD
Translation initiation factor eIF2B subunit delta

6

4

Small-scale

0.944

High

632873

PP12
Serine/threonine-protein phosphatase PP1-2

5

4

Small-scale

0.924

High

632871

EI2BB
Translation initiation factor eIF2B subunit beta

5

4

Small-scale

0.919

High

575302

EI2BA
Translation initiation factor eIF2B subunit alpha

4

4

Small-scale

0.892

High

584341

GCN2
eIF-2-alpha kinase GCN2

2

10

Small-scale

0.778

High

478388

EI2BG
Translation initiation factor eIF2B subunit gamma

11

1

Small-scale

0.758

High

632870

EI2BE
Translation initiation factor eIF2B subunit epsilon

11

1

Small-scale

0.757

High

632886

IF5
Eukaryotic translation initiation factor 5

10

7

Small-scale

0.755

High

478583

IF2B
Eukaryotic translation initiation factor 2 subunit beta

8

6

Small-scale

0.747

High

632885

EIF3A
Eukaryotic translation initiation factor 3 subunit A

4

1

Small-scale

0.694

High

632921

CD123
Translation initiation factor eIF2 assembly protein

3

1

Small-scale

0.664

High

441035

KAPA
cAMP-dependent protein kinase type 1

1

1

Small-scale

0.647

High

632917

PKH1
Serine/threonine-protein kinase PKH1

1

3

Small-scale

0.647

High

632887

KSP1
Serine/threonine-protein kinase KSP1

1

2

High-throughput

0.646

High

401883

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

3

High-throughput

0.618

High

433444

RL26A
Large ribosomal subunit protein uL24A

1

2

High-throughput

0.618

High

632856

PP11
Serine/threonine-protein phosphatase PP1-1

1

4

Small-scale

0.618

High

632874

RSSA1
Small ribosomal subunit protein uS2A

1

1

High-throughput

0.618

High

592004

VATB
V-type proton ATPase subunit B

1

0

High-throughput

0.613

High

632897

IF4F1
Eukaryotic initiation factor 4F subunit p150

2

3

High-throughput

0.611

High

438381

EIF3B
Eukaryotic translation initiation factor 3 subunit B

2

1

Small-scale

0.601

High

632878

RS3A1
Small ribosomal subunit protein eS1A

1

0

High-throughput

0.586

High

632888

RS20
Small ribosomal subunit protein uS10

1

0

High-throughput

0.586

High

543790

SSB1
Ribosome-associated molecular chaperone SSB1

2

3

High-throughput

0.584

High

578829

HSC82
ATP-dependent molecular chaperone HSC82

2

3

High-throughput

0.584

High

632867

HS104
Heat shock protein 104

2

3

High-throughput

0.584

High

632900

EIF3I
Eukaryotic translation initiation factor 3 subunit I

2

4

Small-scale

0.584

High

632906

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

1

High-throughput

0.584

High

394230

EF1A
Elongation factor 1-alpha

1

2

Small-scale

0.575

High

392212

HSP82
ATP-dependent molecular chaperone HSP82

2

3

High-throughput

0.571

High

632857

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

1

High-throughput

0.553

High

632904

CSN11
Cop9 signalosome complex subunit 11

1

0

Small-scale

0.537

High

518199

IF4A
ATP-dependent RNA helicase eIF4A

1

3

High-throughput

0.536

High

632866

XPO1
Exportin-1

1

4

High-throughput

0.536

High

632898

IF4F2
Eukaryotic initiation factor 4F subunit p130

1

3

High-throughput

0.536

High

632914

H3
Histone H3

2

2

High-throughput

0.521

High

632864

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.517

High

453893

IF4E
Eukaryotic translation initiation factor 4E

1

0

High-throughput

0.513

High

591942

THRC
Threonine synthase

1

0

High-throughput

0.513

High

632903

FKH1
Fork head protein homolog 1

1

0

High-throughput

0.513

High

358964

G3P2
Glyceraldehyde-3-phosphate dehydrogenase 2

1

1

High-throughput

0.500

High

359427

G3P1
Glyceraldehyde-3-phosphate dehydrogenase 1

1

1

High-throughput

0.500

High

439239

PDC1
Pyruvate decarboxylase isozyme 1

1

1

High-throughput

0.500

High

632920

POC1
Proteasome chaperone 1

1

0

High-throughput

0.493

High

632882

TAF5
SAGA complex/transcription factor TFIID complex subunit TAF5

1

3

High-throughput

0.489

High

632928

FAL1
ATP-dependent RNA helicase FAL1

1

3

High-throughput

0.489

High

555004

G6PI
Glucose-6-phosphate isomerase

1

0

High-throughput

0.479

High

416194

SYDC
Aspartate--tRNA ligase, cytoplasmic

1

3

High-throughput

0.479

High

434818

RS3
Small ribosomal subunit protein uS3

1

2

High-throughput

0.479

High

436316

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

2

High-throughput

0.479

High

454195

LEUC
3-isopropylmalate dehydratase

1

1

High-throughput

0.479

High

632858

IF5A1
Eukaryotic translation initiation factor 5A-1

1

1

Small-scale

0.479

High

632859

SIS1
Protein SIS1

1

1

High-throughput

0.479

High

632860

RS2
Small ribosomal subunit protein uS5

1

3

High-throughput

0.479

High

504036

RL31A
Large ribosomal subunit protein eL31A

1

1

High-throughput

0.479

High

512815

RS8A
Small ribosomal subunit protein eS8A

1

1

High-throughput

0.479

High

514453

RS18A
Small ribosomal subunit protein uS13A

1

1

High-throughput

0.479

High

523032

HSP71
Heat shock protein SSA1

1

2

High-throughput

0.479

High

533507

AK
Aspartokinase

1

1

High-throughput

0.479

High

581822

SYKC
Lysine--tRNA ligase, cytoplasmic

1

3

High-throughput

0.479

High

632862

CDC48
Cell division control protein 48

1

1

High-throughput

0.479

High

632875

SUI1
Eukaryotic translation initiation factor eIF-1

1

1

Small-scale

0.479

High

632880

GBLP
Small ribosomal subunit protein RACK1

1

5

High-throughput

0.479

High

632884

ATG8
Autophagy-related protein 8

1

1

High-throughput

0.479

High

632889

SYNC
Asparagine--tRNA ligase, cytoplasmic

1

3

High-throughput

0.479

High

632890

OTU2
OTU domain-containing protein 2

1

1

Small-scale

0.479

High

632896

IF2P
Eukaryotic translation initiation factor 5B

1

4

Small-scale

0.479

High

632915

RS15
Small ribosomal subunit protein uS19

1

1

High-throughput

0.479

High

632916

TOM1
E3 ubiquitin-protein ligase TOM1

1

2

High-throughput

0.479

High

632929

DBP10
ATP-dependent RNA helicase DBP10

1

6

High-throughput

0.479

High

632918

UTP15
U3 small nucleolar RNA-associated protein 15

1

5

High-throughput

0.470

High

149580

RS9A
Small ribosomal subunit protein uS4A

1

0

High-throughput

0.458

High

366701

HIS2
Histidine biosynthesis trifunctional protein [Includes: Phosphoribosyl-AMP cyclohydrolase

1

0

High-throughput

0.458

High

383516

RS17A
Small ribosomal subunit protein eS17A

1

0

High-throughput

0.458

High

399342

CARB
Carbamoyl phosphate synthase arginine-specific large chain

1

0

High-throughput

0.458

High

409932

RL25
Large ribosomal subunit protein uL23

1

0

High-throughput

0.458

High

435769

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.458

High

454872

RS19A
Small ribosomal subunit protein eS19A

1

0

High-throughput

0.458

High

502847

RS22A
Small ribosomal subunit protein uS8A

1

0

High-throughput

0.458

High

512253

RS6A
Small ribosomal subunit protein eS6A

1

0

High-throughput

0.458

High

566482

DHAS
Aspartate-semialdehyde dehydrogenase

1

0

High-throughput

0.458

High

632861

KRR1
KRR1 small subunit processome component

1

0

High-throughput

0.458

High

632863

RS7A
Small ribosomal subunit protein eS7A

1

0

High-throughput

0.458

High

632865

BMH1
Protein BMH1

1

0

High-throughput

0.458

High

632869

EIF3C
Eukaryotic translation initiation factor 3 subunit C

1

0

High-throughput

0.458

High

632876

PRS6A
26S proteasome regulatory subunit 6A

1

0

High-throughput

0.458

High

632879

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.458

High

632891

RPN1
26S proteasome regulatory subunit RPN1

1

0

High-throughput

0.458

High

632892

RPN10
26S proteasome regulatory subunit RPN10

1

0

High-throughput

0.458

High

632894

STM1
Suppressor protein STM1

1

0

Small-scale

0.458

High

632895

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.458

High

632902

TM108
Protein TMA108

1

0

High-throughput

0.458

High

632907

3HAO
3-hydroxyanthranilate 3,4-dioxygenase

1

0

High-throughput

0.458

High

632909

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.458

High

632911

PESC
Pescadillo homolog

1

0

High-throughput

0.458

High

632923

SGO1
Shugoshin

1

0

High-throughput

0.458

High

632924

RS10A
Small ribosomal subunit protein eS10A

1

0

High-throughput

0.458

High

376177

RAS1
Ras-like protein 1

1

1

High-throughput

0.445

High

632872

HSP7F
Heat shock protein homolog SSE1

1

5

High-throughput

0.445

High

632877

HSP78
Heat shock protein 78, mitochondrial

1

3

High-throughput

0.445

High

632899

SSB2
Ribosome-associated molecular chaperone SSB2

1

3

High-throughput

0.445

High

632912

APJ1
J domain-containing protein APJ1

1

1

High-throughput

0.445

High

381865

H4
Histone H4

1

1

High-throughput

0.437

High

632901

MLP2
Protein MLP2

1

3

High-throughput

0.437

High

632925

NCBP2
Nuclear cap-binding protein subunit 2

1

1

High-throughput

0.437

High

632881

ATPG
ATP synthase subunit gamma, mitochondrial

1

0

High-throughput

0.279

Low

632883

NU170
Nucleoporin NUP170

1

0

High-throughput

0.249

Low

632893

GGC1
Mitochondrial GTP/GDP carrier protein 1

1

0

High-throughput

0.249

Low

632905

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.249

Low

632908

HOSC
Homocitrate synthase, cytosolic isozyme

1

0

High-throughput

0.249

Low

632910

MTHR2
Methylenetetrahydrofolate reductase 2

1

0

High-throughput

0.249

Low

632913

SAM50
Sorting assembly machinery 50 kDa subunit

1

0

High-throughput

0.249

Low

632922

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.249

Low

632926

AP3D
AP-3 complex subunit delta

1

0

High-throughput

0.249

Low

632919

TAF9
SAGA complex/transcription factor TFIID complex subunit TAF9

1

0

High-throughput

0.232

Low

632927

HFI1
SAGA complex subunit HFI1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025