Protein: IF2P
Eukaryotic translation initiation factor 5B (eIF-5B) (EC 3.6.5.3) (Translation initiation factor IF-2)

Gene: IF2P, FUN12
Organism: Saccharomyces cerevisiae S288C
Interactions: 230
UniProt ID: P39730

Gene Ontology (top 5):
GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0001732 - formation of cytoplasmic translation initiation complex
GO:0003743 - translation initiation factor activity
GO:0003924 - GTPase activity
GO:0005525 - GTP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

807189

IF1A
Eukaryotic translation initiation factor 1A

5

6

Small-scale

0.936

High

799746

IF5
Eukaryotic translation initiation factor 5

3

4

High-throughput

0.855

High

737727

IF2G
Eukaryotic translation initiation factor 2 subunit gamma

2

10

Small-scale

0.776

High

478621

IF2B
Eukaryotic translation initiation factor 2 subunit beta

2

4

Small-scale

0.754

High

427287

RLA0
Large ribosomal subunit protein uL10

2

0

High-throughput

0.748

High

438436

EIF3B
Eukaryotic translation initiation factor 3 subunit B

6

1

Small-scale

0.730

High

482020

C1TM
C-1-tetrahydrofolate synthase, mitochondrial

3

2

High-throughput

0.662

High

813981

ARB1
ABC transporter ATP-binding protein ARB1

3

6

Small-scale

0.662

High

738386

EIF3C
Eukaryotic translation initiation factor 3 subunit C

4

0

Small-scale

0.661

High

513689

RL2A
Large ribosomal subunit protein uL2A

3

3

High-throughput

0.640

High

796576

EIF3A
Eukaryotic translation initiation factor 3 subunit A

3

1

Small-scale

0.640

High

579425

HSC82
ATP-dependent molecular chaperone HSC82

3

8

High-throughput

0.633

High

814035

EIF3G
Eukaryotic translation initiation factor 3 subunit G

3

0

Small-scale

0.628

High

432847

RL9A
Large ribosomal subunit protein uL6A

1

2

High-throughput

0.618

High

813935

RBG1
Ribosome-interacting GTPase 1

1

5

High-throughput

0.618

High

814010

RL9B
Large ribosomal subunit protein uL6B

1

2

High-throughput

0.618

High

432590

RL7A
Large ribosomal subunit protein uL30A

2

3

High-throughput

0.611

High

434165

RL36A
Large ribosomal subunit protein eL36A

2

1

High-throughput

0.611

High

435106

RS3
Small ribosomal subunit protein uS3

2

1

High-throughput

0.611

High

503055

RS22A
Small ribosomal subunit protein uS8A

2

2

High-throughput

0.611

High

570023

RL3
Large ribosomal subunit protein uL3

2

1

High-throughput

0.611

High

601050

RL8A
Large ribosomal subunit protein eL8A

2

2

High-throughput

0.611

High

712576

RL8B
Large ribosomal subunit protein eL8B

2

2

High-throughput

0.611

High

813984

RL13B
Large ribosomal subunit protein eL13B

2

1

High-throughput

0.611

High

814066

RL13A
Large ribosomal subunit protein eL13A

2

1

High-throughput

0.611

High

751401

CBF5
H/ACA ribonucleoprotein complex subunit CBF5

2

0

High-throughput

0.602

High

814022

MCE1
mRNA-capping enzyme subunit alpha

2

0

High-throughput

0.595

High

751228

DOM34
Protein DOM34

1

0

High-throughput

0.586

High

569791

RL30
Large ribosomal subunit protein eL30

2

0

High-throughput

0.585

High

813992

RL10
Large ribosomal subunit protein uL16

2

0

High-throughput

0.585

High

149776

RS9A
Small ribosomal subunit protein uS4A

2

1

High-throughput

0.584

High

433652

RL26A
Large ribosomal subunit protein uL24A

2

1

High-throughput

0.584

High

504222

RL31A
Large ribosomal subunit protein eL31A

2

2

High-throughput

0.584

High

670735

SIS1
Protein SIS1

2

9

High-throughput

0.584

High

689039

RL16A
Large ribosomal subunit protein uL13A

2

6

High-throughput

0.584

High

813979

IF4F1
Eukaryotic initiation factor 4F subunit p150

2

2

Small-scale

0.584

High

813980

IF4F2
Eukaryotic initiation factor 4F subunit p130

2

1

Small-scale

0.584

High

813994

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

3

High-throughput

0.584

High

394584

EF1A
Elongation factor 1-alpha

1

3

High-throughput

0.575

High

531749

RL4A
Large ribosomal subunit protein uL4A

2

1

High-throughput

0.571

High

814006

RL4B
Large ribosomal subunit protein uL4B

2

1

High-throughput

0.571

High

814018

JJJ1
J protein JJJ1

2

4

High-throughput

0.571

High

585277

FBRL
rRNA 2'-O-methyltransferase fibrillarin

2

1

High-throughput

0.567

High

814014

GATF
Glutamyl-tRNA(Gln) amidotransferase subunit F, mitochondrial

2

0

High-throughput

0.563

High

410146

RL25
Large ribosomal subunit protein uL23

2

0

High-throughput

0.559

High

511204

RL20B
Large ribosomal subunit protein eL20B

2

0

High-throughput

0.559

High

512080

RS4A
Small ribosomal subunit protein eS4A

2

0

High-throughput

0.559

High

514291

RL12B
Large ribosomal subunit protein uL11B

2

0

High-throughput

0.559

High

814024

RS15
Small ribosomal subunit protein uS19

2

0

Small-scale

0.559

High

427572

RLA1
Large ribosomal subunit protein P1A

2

1

Small-scale

0.558

High

524012

HSP71
Heat shock protein SSA1

2

8

High-throughput

0.552

High

544946

SSB1
Ribosome-associated molecular chaperone SSB1

2

7

High-throughput

0.552

High

813983

SSB2
Ribosome-associated molecular chaperone SSB2

2

7

High-throughput

0.552

High

814061

RIO1
Serine/threonine-protein kinase RIO1

2

0

High-throughput

0.547

High

751080

PDR5
Pleiotropic ABC efflux transporter of multiple drugs

1

1

High-throughput

0.541

High

688893

RS5
Small ribosomal subunit protein uS7

1

5

High-throughput

0.536

High

721953

XPO1
Exportin-1

1

3

High-throughput

0.536

High

802082

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

1

5

High-throughput

0.536

High

814008

IMDH3
Inosine-5'-monophosphate dehydrogenase 3

1

5

High-throughput

0.536

High

814017

BRE5
UBP3-associated protein BRE5

1

2

High-throughput

0.536

High

814069

RS22B
Small ribosomal subunit protein uS8B

1

2

High-throughput

0.536

High

454447

PHO4
Phosphate system positive regulatory protein PHO4

1

0

High-throughput

0.513

High

813989

SGN1
RNA-binding protein SGN1

1

0

High-throughput

0.513

High

814023

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

0

High-throughput

0.513

High

814046

MAG2
E3 ubiquitin-protein ligase MAG2

1

0

High-throughput

0.513

High

813998

ALB1
Ribosome biogenesis protein ALB1

1

0

High-throughput

0.493

High

814040

RRP5
rRNA biogenesis protein RRP5

1

4

High-throughput

0.489

High

814070

AP2M
AP-2 complex subunit mu

1

3

Small-scale

0.481

High

154173

RL36B
Large ribosomal subunit protein eL36B

1

1

High-throughput

0.479

High

364545

CDK1
Cyclin-dependent kinase 1

1

2

High-throughput

0.479

High

383131

RLA4
Large ribosomal subunit protein P2B

1

1

High-throughput

0.479

High

392763

HSP82
ATP-dependent molecular chaperone HSP82

1

8

High-throughput

0.479

High

409733

RL24A
Large ribosomal subunit protein eL24A

1

1

High-throughput

0.479

High

433026

RL6B
Large ribosomal subunit protein eL6B

1

2

High-throughput

0.479

High

433212

RL17A
Large ribosomal subunit protein uL22A

1

3

High-throughput

0.479

High

434025

RL33A
Large ribosomal subunit protein eL33A

1

1

High-throughput

0.479

High

434576

RL22A
Large ribosomal subunit protein eL22A

1

1

High-throughput

0.479

High

435572

RS9B
Small ribosomal subunit protein uS4B

1

1

High-throughput

0.479

High

436419

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

7

High-throughput

0.479

High

438699

SC160
Protein SCP160

1

1

High-throughput

0.479

High

441917

RS14A
Small ribosomal subunit protein uS11A

1

2

High-throughput

0.479

High

503795

RL27A
Large ribosomal subunit protein eL27A

1

1

High-throughput

0.479

High

503920

RL27B
Large ribosomal subunit protein eL27B

1

1

High-throughput

0.479

High

504530

RL31B
Large ribosomal subunit protein eL31B

1

2

High-throughput

0.479

High

514647

RS18A
Small ribosomal subunit protein uS13A

1

1

High-throughput

0.479

High

597463

EF3A
Elongation factor 3A

1

4

High-throughput

0.479

High

632896

IF2A
Eukaryotic translation initiation factor 2 subunit alpha

1

4

Small-scale

0.479

High

663678

RL24B
Large ribosomal subunit protein eL24B

1

1

High-throughput

0.479

High

674636

RS2
Small ribosomal subunit protein uS5

1

7

High-throughput

0.479

High

679703

CDC48
Cell division control protein 48

1

2

High-throughput

0.479

High

689220

RL16B
Large ribosomal subunit protein uL13B

1

6

High-throughput

0.479

High

689469

RS7A
Small ribosomal subunit protein eS7A

1

1

High-throughput

0.479

High

709769

BMH1
Protein BMH1

1

2

High-throughput

0.479

High

727044

HS104
Heat shock protein 104

1

16

High-throughput

0.479

High

747375

RSSA1
Small ribosomal subunit protein uS2A

1

6

High-throughput

0.479

High

748400

SC61A
Protein transport protein SEC61

1

2

High-throughput

0.479

High

781197

RL14A
Large ribosomal subunit protein eL14A

1

2

High-throughput

0.479

High

790250

GLYM
Serine hydroxymethyltransferase, mitochondrial

1

2

High-throughput

0.479

High

792059

GBLP
Small ribosomal subunit protein RACK1

1

2

High-throughput

0.479

High

792523

RL32
Large ribosomal subunit protein eL32

1

1

High-throughput

0.479

High

802186

RS20
Small ribosomal subunit protein uS10

1

2

High-throughput

0.479

High

803395

RL14B
Large ribosomal subunit protein eL14B

1

2

High-throughput

0.479

High

812034

DHH1
ATP-dependent RNA helicase DHH1

1

1

High-throughput

0.479

High

812312

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.479

High

813985

EIF3I
Eukaryotic translation initiation factor 3 subunit I

1

2

High-throughput

0.479

High

813988

RL34B
Large ribosomal subunit protein eL34B

1

1

High-throughput

0.479

High

813991

RL33B
Large ribosomal subunit protein eL33B

1

1

High-throughput

0.479

High

813993

ELP2
Elongator complex protein 2

1

1

High-throughput

0.479

High

813996

RSSA2
Small ribosomal subunit protein uS2B

1

6

High-throughput

0.479

High

813997

RL17B
Large ribosomal subunit protein uL22B

1

3

High-throughput

0.479

High

814000

RS7B
Small ribosomal subunit protein eS7B

1

1

High-throughput

0.479

High

814004

RL37A
Large ribosomal subunit protein eL37A

1

1

High-throughput

0.479

High

814011

RL37B
Large ribosomal subunit protein eL37B

1

1

High-throughput

0.479

High

814012

RL26B
Large ribosomal subunit protein uL24B

1

1

High-throughput

0.479

High

814013

EIF2A
Eukaryotic translation initiation factor 2A

1

1

High-throughput

0.479

High

814019

FAP1
FKBP12-associated protein 1

1

2

High-throughput

0.479

High

814020

RL22B
Large ribosomal subunit protein eL22B

1

1

High-throughput

0.479

High

814021

RL34A
Large ribosomal subunit protein eL34A

1

1

High-throughput

0.479

High

814025

RL6A
Large ribosomal subunit protein eL6A

1

2

High-throughput

0.479

High

814026

ABF2
ARS-binding factor 2, mitochondrial

1

4

High-throughput

0.479

High

814027

RL21A
Large ribosomal subunit protein eL21A

1

1

High-throughput

0.479

High

814028

XRN2
5'-3' exoribonuclease 2

1

1

High-throughput

0.479

High

814031

TOM1
E3 ubiquitin-protein ligase TOM1

1

4

High-throughput

0.479

High

814032

CLU
Clustered mitochondria protein 1

1

1

High-throughput

0.479

High

814033

HMO1
High mobility group protein 1

1

4

High-throughput

0.479

High

814036

DHR1
Probable ATP-dependent RNA helicase DHR1

1

3

High-throughput

0.479

High

814043

EFM7
Protein N-terminal and lysine N-methyltransferase EFM7

1

1

High-throughput

0.479

High

814050

VAM6
Vacuolar morphogenesis protein 6

1

1

High-throughput

0.479

High

814058

CHS5
Chitin biosynthesis protein CHS5

1

1

High-throughput

0.479

High

814065

RL21B
Large ribosomal subunit protein eL21B

1

1

High-throughput

0.479

High

781622

DBP7
ATP-dependent RNA helicase DBP7

1

2

High-throughput

0.470

High

383711

RS17A
Small ribosomal subunit protein eS17A

1

0

High-throughput

0.458

High

415019

RL39
Large ribosomal subunit protein eL39

1

0

High-throughput

0.458

High

434254

RL29
Large ribosomal subunit protein eL29

1

0

High-throughput

0.458

High

434378

RL15A
Large ribosomal subunit protein eL15A

1

0

High-throughput

0.458

High

435977

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.458

High

455074

RS19A
Small ribosomal subunit protein eS19A

1

0

High-throughput

0.458

High

511427

RL43B
Large ribosomal subunit protein eL43B

1

0

High-throughput

0.458

High

512451

RS6A
Small ribosomal subunit protein eS6A

1

0

High-throughput

0.458

High

513020

RS8A
Small ribosomal subunit protein eS8A

1

0

High-throughput

0.458

High

514002

RL18B
Large ribosomal subunit protein eL18B

1

0

High-throughput

0.458

High

515104

RL19B
Large ribosomal subunit protein eL19

1

0

High-throughput

0.458

High

515261

RL35A
Large ribosomal subunit protein uL29A

1

0

High-throughput

0.458

High

515368

RS32B
Small ribosomal subunit protein eS32B

1

0

High-throughput

0.458

High

553541

PDR1
Transcription factor PDR1

1

0

High-throughput

0.458

High

558732

CAF20
Cap-associated protein CAF20

1

0

High-throughput

0.458

High

594375

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

0

High-throughput

0.458

High

666467

DBP2
ATP-dependent RNA helicase DBP2

1

0

High-throughput

0.458

High

666660

AP2
AP-1-like transcription factor YAP2

1

0

High-throughput

0.458

High

684735

RL5
Large ribosomal subunit protein uL18

1

0

High-throughput

0.458

High

745747

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

0

High-throughput

0.458

High

753381

RS3A1
Small ribosomal subunit protein eS1A

1

0

High-throughput

0.458

High

778339

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.458

High

782163

LAS1
Protein LAS1

1

0

Small-scale

0.458

High

795358

ATG8
Autophagy-related protein 8

1

0

High-throughput

0.458

High

796940

PHO88
SRP-independent targeting protein 3

1

0

High-throughput

0.458

High

797740

AIM4
Altered inheritance of mitochondria protein 4

1

0

High-throughput

0.458

High

805939

CRP1
Cruciform DNA-recognizing protein 1 [Cleaved into: CRP1 short N-terminal subpeptide; CRP1 short C-terminal subpeptide]

1

0

High-throughput

0.458

High

806715

RPN10
26S proteasome regulatory subunit RPN10

1

0

High-throughput

0.458

High

809313

STM1
Suppressor protein STM1

1

0

High-throughput

0.458

High

813694

ECM1
Shuttling pre-60S factor ECM1

1

0

High-throughput

0.458

High

813986

YIQ1
Uncharacterized protein YIL161W

1

0

High-throughput

0.458

High

813987

TM108
Protein TMA108

1

0

High-throughput

0.458

High

814002

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.458

High

814005

RL38
Large ribosomal subunit protein eL38

1

0

High-throughput

0.458

High

814009

PSP2
Protein PSP2

1

0

High-throughput

0.458

High

814015

PESC
Pescadillo homolog

1

0

High-throughput

0.458

High

814016

TR112
Multifunctional methyltransferase subunit TRM112

1

0

Small-scale

0.458

High

814029

ELP4
Elongator complex protein 4

1

0

High-throughput

0.458

High

814030

ELP3
Elongator complex protein 3

1

0

High-throughput

0.458

High

814034

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.458

High

814041

RQC1
Ribosome quality control complex subunit 1

1

0

High-throughput

0.458

High

814044

LCB5
Sphingoid long chain base kinase 5

1

0

High-throughput

0.458

High

814049

ELP1
Elongator complex protein 1

1

0

High-throughput

0.458

High

814051

NOB1
20S-pre-rRNA D-site endonuclease NOB1

1

0

Small-scale

0.458

High

814052

SGO1
Shugoshin

1

0

High-throughput

0.458

High

814053

RS10A
Small ribosomal subunit protein eS10A

1

0

High-throughput

0.458

High

814055

TMA46
Translation machinery-associated protein 46

1

0

High-throughput

0.458

High

814057

AEP3
ATPase expression protein 3

1

0

Small-scale

0.458

High

814064

RQC2
Ribosome quality control complex subunit 2

1

0

High-throughput

0.458

High

814067

RL11B
Large ribosomal subunit protein uL5B

1

0

High-throughput

0.458

High

814068

RS25A
Small ribosomal subunit protein eS25A

1

0

High-throughput

0.458

High

510511

HSP77
Import motor subunit, mitochondrial

1

7

High-throughput

0.445

High

526747

HSP72
Heat shock protein SSA2

1

8

High-throughput

0.445

High

645421

XRN1
5'-3' exoribonuclease 1

1

1

High-throughput

0.445

High

676017

MAS5
Mitochondrial protein import protein MAS5

1

7

High-throughput

0.445

High

741619

HSP7F
Heat shock protein homolog SSE1

1

11

High-throughput

0.445

High

752283

HSP78
Heat shock protein 78, mitochondrial

1

13

High-throughput

0.445

High

804176

SSZ1
Ribosome-associated complex subunit SSZ1

1

2

High-throughput

0.445

High

811317

CAJ1
Protein CAJ1

1

10

High-throughput

0.445

High

814007

IMDH4
Inosine-5'-monophosphate dehydrogenase 4

1

5

High-throughput

0.445

High

814062

RL7B
Large ribosomal subunit protein uL30B

1

3

High-throughput

0.445

High

811206

PCF11
Protein PCF11

1

0

High-throughput

0.438

High

528824

RLA3
Large ribosomal subunit protein P1B

1

1

High-throughput

0.437

High

567682

ACOX
Acyl-coenzyme A oxidase

1

3

High-throughput

0.437

High

682286

SPB4
ATP-dependent rRNA helicase SPB4

1

1

High-throughput

0.437

High

707156

TF2B
Transcription initiation factor IIB

1

3

High-throughput

0.437

High

794995

NU170
Nucleoporin NUP170

1

1

High-throughput

0.437

High

814039

POB3
FACT complex subunit POB3

1

1

High-throughput

0.437

High

814042

HRQ1
ATP-dependent helicase HRQ1

1

4

Small-scale

0.437

High

814054

AP3D
AP-3 complex subunit delta

1

1

High-throughput

0.437

High

814063

DBP10
ATP-dependent RNA helicase DBP10

1

10

High-throughput

0.437

High

386717

TBB
Tubulin beta chain

1

0

High-throughput

0.426

High

813995

ERJ5
ER-localized J domain-containing protein 5

1

10

High-throughput

0.407

High

814001

HLJ1
Protein HLJ1

1

8

High-throughput

0.407

High

814037

PUF6
Pumilio homology domain family member 6

3

0

Small-scale

0.353

High

382110

H4
Histone H4

2

0

High-throughput

0.307

High

644660

MAG
DNA-3-methyladenine glycosylase

1

0

High-throughput

0.279

Low

814038

KU80
ATP-dependent DNA helicase II subunit 2

1

0

High-throughput

0.279

Low

814060

MAK21
Ribosome biogenesis protein MAK21

1

0

High-throughput

0.269

Low

745187

CDC13
Cell division control protein 13

1

0

Small-scale

0.265

Low

548205

BIK1
Nuclear fusion protein BIK1

1

0

High-throughput

0.251

Low

814056

NOP53
Ribosome biogenesis protein NOP53

1

0

High-throughput

0.251

Low

639894

DAL82
Protein DAL82

1

0

High-throughput

0.249

Low

677404

KRR1
KRR1 small subunit processome component

1

0

High-throughput

0.249

Low

734822

SRP21
Signal recognition particle subunit SRP21

1

0

High-throughput

0.249

Low

779236

CENPA
Histone H3-like centromeric protein CSE4

1

0

High-throughput

0.249

Low

800705

RCK1
Serine/threonine-protein kinase RCK1

1

0

High-throughput

0.249

Low

801745

SRP72
Signal recognition particle subunit SRP72

1

0

High-throughput

0.249

Low

803862

CIC1
Proteasome-interacting protein CIC1

1

0

High-throughput

0.249

Low

808823

UME6
Transcriptional regulatory protein UME6

1

0

High-throughput

0.249

Low

813982

THO1
Protein THO1

1

0

High-throughput

0.249

Low

813990

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.249

Low

813999

MOG1
Nuclear import protein MOG1

1

0

High-throughput

0.249

Low

814003

VATG
V-type proton ATPase subunit G

1

0

High-throughput

0.249

Low

814045

PEX30
Peroxisomal membrane protein PEX30

1

0

Small-scale

0.249

Low

814047

URN1
Pre-mRNA-splicing factor URN1

1

0

High-throughput

0.249

Low

814059

YRA1
RNA annealing protein YRA1

1

0

High-throughput

0.249

Low

814071

ENV10
SRP-independent targeting protein 2

1

0

High-throughput

0.249

Low

814048

CSC1
Calcium permeable stress-gated cation channel 1

1

0

High-throughput

0.238

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025