HitPredict

Interactor 1: H31 (P68431)
Histone H3.1 (Histone H3/a) (Histone H3/b) (Histone H3/c) (Histone H3/d) (Histone H3/f) (Histone H3/h) (Histone H3/i) (Histone H3/j) (Histone H3/k) (Histone H3/l)
Gene: H3C1

Interactor 2: EZH2 (Q15910)
Histone-lysine N-methyltransferase EZH2 (EC 2.1.1.356) (ENX-1) (Enhancer of zeste homolog 2) (Lysine N-methyltransferase 6)
Gene: EZH2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.92	1.00	0.962

Property	Details
Experiments	34079125, 36089195, 33479123, 35013218, 36517590, 16431907, 16224021
Identification Methods	proximity labelling technology, enzymatic study, affinity chromatography technology
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	Histone~preSET_CXC, Histone~SET
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006325 - chromatin organization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 136 Hs			1 746
+	Hs
		1079993 H31T_HUMAN (1-136): 1.27e-61: 187: 97.06		EZH2_HUMAN (1-746): 0: 862: 100.00
+	Hs
		331780 H31_HUMAN (1-136): 2.8e-62: 188: 100.00		NSD2_HUMAN (275-729): 1.99e-91: 314: 16.03
+	Hs
		331823 H31T_HUMAN (1-136): 1.27e-61: 187: 97.06		NSD2_HUMAN (275-729): 1.99e-91: 314: 16.03
+	Hs
		935129 H31_HUMAN (1-136): 2.8e-62: 188: 100.00		NSD1_HUMAN (275-729): 6.24e-90: 311: 15.82
+	Hs
		1086280 H31T_HUMAN (1-136): 1.27e-61: 187: 97.06		NSD1_HUMAN (275-729): 6.24e-90: 311: 15.82
+	Hs
		935204 H31_HUMAN (1-136): 2.8e-62: 188: 100.00		SETD2_HUMAN (190-732): 2.07e-89: 310: 16.64
+	Hs
		1086306 H31T_HUMAN (1-136): 1.27e-61: 187: 97.06		SETD2_HUMAN (190-732): 2.07e-89: 310: 16.64
+	Hs
		935251 H31_HUMAN (1-136): 2.8e-62: 188: 100.00		EHMT1_HUMAN (441-732): 1.73e-70: 253: 24.27
+	Hs
		935205 H31_HUMAN (1-136): 2.8e-62: 188: 100.00		NSD3_HUMAN (275-729): 9.41e-70: 251: 14.42
+	Hs
		1086307 H31T_HUMAN (1-136): 1.27e-61: 187: 97.06		NSD3_HUMAN (275-729): 9.41e-70: 251: 14.42
+	Hs
		935126 H31_HUMAN (1-136): 2.8e-62: 188: 100.00		EHMT2_HUMAN (467-732): 1.91e-68: 247: 24.21
+	Hs
		935237 H31_HUMAN (1-136): 2.8e-62: 188: 100.00		SUV92_HUMAN (447-734): 5.41e-74: 247: 24.10
+	Hs
		1086279 H31T_HUMAN (1-136): 1.27e-61: 187: 97.06		EHMT2_HUMAN (467-732): 1.91e-68: 247: 24.21
+	At
		886462 H33_ARATH (1-136): 7.67e-62: 187: 96.32		SUVH4_ARATH (186-733): 6.35e-70: 242: 12.58
+	Hs
		203659 H31_HUMAN (1-136): 2.8e-62: 188: 100.00		SUV91_HUMAN (354-731): 2.25e-71: 240: 19.90
+	Hs
		935276 H31_HUMAN (1-136): 2.8e-62: 188: 100.00		ASH1L_HUMAN (547-732): 3.87e-57: 214: 30.85
+	Hs
		934681 H31_HUMAN (1-136): 2.8e-62: 188: 100.00		KMT2A_HUMAN (606-733): 6.89e-19: 94.4: 39.54
+	Hs
		975268 H31T_HUMAN (1-136): 1.27e-61: 187: 97.06		KMT2A_HUMAN (606-733): 6.89e-19: 94.4: 39.54
+	Hs
		935374 H31_HUMAN (1-136): 2.8e-62: 188: 100.00		SET1B_HUMAN (619-732): 1.38e-18: 93.2: 40.52
+	Hs
		165661 H31_HUMAN (1-136): 2.8e-62: 188: 100.00		SET1A_HUMAN (611-732): 3.19e-18: 92: 38.71