HitPredict

Interactor 1: H31 (P68431)
Histone H3.1 (Histone H3/a) (Histone H3/b) (Histone H3/c) (Histone H3/d) (Histone H3/f) (Histone H3/h) (Histone H3/i) (Histone H3/j) (Histone H3/k) (Histone H3/l)
Gene: H3C1

Interactor 2: NSD3 (Q9BZ95)
Histone-lysine N-methyltransferase NSD3 (EC 2.1.1.370) (EC 2.1.1.371) (Nuclear SET domain-containing protein 3) (Protein whistle) (WHSC1-like 1 isoform 9 with methyltransferase activity to lysine) (Wolf-Hirschhorn syndrome candidate 1-like protein 1) (WHSC1-like protein 1)
Gene: NSD3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.87	1.00	0.934

Property	Details
Experiments	25494638, 33361816, 26912663, 34079125, 34271259, 36089195
Identification Methods	enzymatic study, pull down, proximity labelling technology, unspecified method
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	AWS~Histone, Histone~PWWP, Histone~SET
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 136 Hs			1 1437
+	Hs
		331780 H31_HUMAN (1-136): 2.8e-62: 188: 100.00		NSD2_HUMAN (140-1414): 0: 825: 45.08
+	Hs
		331823 H31T_HUMAN (1-136): 1.27e-61: 187: 97.06		NSD2_HUMAN (140-1414): 0: 825: 45.08
+	Hs
		855452 H31_HUMAN (1-136): 2.8e-62: 188: 100.00		MSH6_HUMAN (233-594): 7.56e-72: 266: 18.55
+	Hs
		935237 H31_HUMAN (1-136): 2.8e-62: 188: 100.00		SUV92_HUMAN (903-1285): 1.04e-77: 265: 23.22
+	Hs
		203659 H31_HUMAN (1-136): 2.8e-62: 188: 100.00		SUV91_HUMAN (904-1285): 4e-73: 252: 22.56
+	Hs
		935276 H31_HUMAN (1-136): 2.8e-62: 188: 100.00		ASH1L_HUMAN (1002-1314): 3.35e-61: 234: 29.85
+	Hs
		935126 H31_HUMAN (1-136): 2.8e-62: 188: 100.00		EHMT2_HUMAN (1029-1281): 2.28e-60: 229: 22.84
+	Hs
		1086279 H31T_HUMAN (1-136): 1.27e-61: 187: 97.06		EHMT2_HUMAN (1029-1281): 2.28e-60: 229: 22.84
+	Hs
		935204 H31_HUMAN (1-136): 2.8e-62: 188: 100.00		SETD2_HUMAN (1004-1320): 1.62e-59: 228: 32.18
+	Hs
		1086306 H31T_HUMAN (1-136): 1.27e-61: 187: 97.06		SETD2_HUMAN (1004-1320): 1.62e-59: 228: 32.18
+	Hs
		935251 H31_HUMAN (1-136): 2.8e-62: 188: 100.00		EHMT1_HUMAN (995-1301): 1.89e-59: 227: 20.54
+	Hs
		934804 H31_HUMAN (1-136): 2.8e-62: 188: 100.00		EZH2_HUMAN (1076-1270): 1.53e-58: 218: 28.78
+	Hs
		1079993 H31T_HUMAN (1-136): 1.27e-61: 187: 97.06		EZH2_HUMAN (1076-1270): 1.53e-58: 218: 28.78
+	Hs
		934681 H31_HUMAN (1-136): 2.8e-62: 188: 100.00		KMT2A_HUMAN (1131-1285): 7.1e-40: 164: 30.13
+	Hs
		975268 H31T_HUMAN (1-136): 1.27e-61: 187: 97.06		KMT2A_HUMAN (1131-1285): 7.1e-40: 164: 30.13
+	Hs
		935129 H31_HUMAN (1-136): 2.8e-62: 188: 100.00		NSD1_HUMAN (91-724): 2.53e-28: 126: 15.30
+	Hs
		1086280 H31T_HUMAN (1-136): 1.27e-61: 187: 97.06		NSD1_HUMAN (91-724): 2.53e-28: 126: 15.30
+	Hs
		935004 H31_HUMAN (1-136): 2.8e-62: 188: 100.00		KMT2C_HUMAN (1278-1411): 2.31e-13: 77.9: 15.75
+	Hs
		1086228 H31T_HUMAN (1-136): 1.27e-61: 187: 97.06		KMT2C_HUMAN (1278-1411): 2.31e-13: 77.9: 15.75
+	Hs
		935368 H31_HUMAN (1-136): 2.8e-62: 188: 100.00		KMT2B_HUMAN (1323-1421): 9.58e-09: 62.5: 19.83