Protein: SYT2
Synaptotagmin-2 (Synaptotagmin II) (SytII)

Gene: SYT2
Organism: Homo sapiens
Interactions: 169
UniProt ID: Q8N9I0

Gene Ontology (top 5):
GO:0000149 - SNARE binding
GO:0005544 - calcium-dependent phospholipid binding
GO:0005886 - plasma membrane
GO:0016192 - vesicle-mediated transport
GO:0017158 - regulation of calcium ion-dependent exocytosis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

639149

SYT1
Synaptotagmin-1

3

19

High-throughput

0.855

High

1295432

C2CD5
C2 domain-containing protein 5

1

19

High-throughput

0.691

High

136170

SYT5
Synaptotagmin-5

1

17

High-throughput

0.665

High

278532

VAMP4
Vesicle-associated membrane protein 4

2

4

High-throughput

0.606

High

390919

TRFE
Serotransferrin

2

1

High-throughput

0.606

High

719075

MIP
Lens fiber major intrinsic protein

2

1

High-throughput

0.606

High

1007401

S35A1
CMP-sialic acid transporter

2

1

High-throughput

0.606

High

1331842

AQP10
Aquaporin-10

2

2

High-throughput

0.606

High

126150

AP3B1
AP-3 complex subunit beta-1

2

4

High-throughput

0.601

High

1022521

VLDLR
Very low-density lipoprotein receptor

2

4

High-throughput

0.601

High

1124209

EI2BA
Translation initiation factor eIF2B subunit alpha

2

5

High-throughput

0.601

High

1331861

E41L5
Band 4.1-like protein 5

2

1

High-throughput

0.601

High

843777

HD
Huntingtin

2

9

High-throughput

0.588

High

154500

CLD4
Claudin-4

2

0

High-throughput

0.580

High

220391

LAT
Linker for activation of T-cells family member 1

2

0

High-throughput

0.580

High

539482

ITAM
Integrin alpha-M

2

0

High-throughput

0.580

High

1030371

PMP22
Peripheral myelin protein 22

2

0

High-throughput

0.580

High

1092789

MALL
MAL-like protein

2

0

High-throughput

0.580

High

1216438

TSPO2
Translocator protein 2

2

0

High-throughput

0.580

High

1219810

PLPP4
Phospholipid phosphatase 4

2

0

High-throughput

0.580

High

1310893

ZNT8
Proton-coupled zinc antiporter SLC30A8

2

0

High-throughput

0.580

High

1322821

ORML3
ORM1-like protein 3

2

0

High-throughput

0.580

High

1331834

SIR1
NAD-dependent protein deacetylase sirtuin-1

2

0

High-throughput

0.576

High

1331872

VTI1B
Vesicle transport through interaction with t-SNAREs homolog 1B

2

0

High-throughput

0.576

High

1331826

STON2
Stonin-2

2

4

Small-scale

0.565

High

1092021

BNIP2
BCL2/adenovirus E1B 19 kDa protein-interacting protein 2

2

1

High-throughput

0.553

High

1272367

FA2H
Fatty acid 2-hydroxylase

2

1

High-throughput

0.553

High

1331835

S35A4
Probable UDP-sugar transporter protein SLC35A4

2

1

High-throughput

0.553

High

1331852

SNAB
Beta-soluble NSF attachment protein

2

1

High-throughput

0.553

High

230067

SAHH2
S-adenosylhomocysteine hydrolase-like protein 1

2

3

High-throughput

0.549

High

451546

CENPB
Major centromere autoantigen B

2

1

High-throughput

0.549

High

890143

EI2BB
Translation initiation factor eIF2B subunit beta

2

5

High-throughput

0.549

High

1040740

ENL
Protein ENL

2

3

High-throughput

0.549

High

1095909

EI2BE
Translation initiation factor eIF2B subunit epsilon

2

3

High-throughput

0.549

High

1186494

CHD9
Chromodomain-helicase-DNA-binding protein 9

2

1

High-throughput

0.549

High

1250494

RBP10
Ran-binding protein 10

2

3

High-throughput

0.549

High

1331829

RTF1
RNA polymerase-associated protein RTF1 homolog

2

1

High-throughput

0.549

High

1331836

SAHH3
Adenosylhomocysteinase 3

2

3

High-throughput

0.549

High

1331837

NAF1
H/ACA ribonucleoprotein complex non-core subunit NAF1

2

1

High-throughput

0.549

High

1331844

NP1L3
Nucleosome assembly protein 1-like 3

2

1

High-throughput

0.549

High

1331850

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

2

1

High-throughput

0.549

High

1331860

CWC22
Pre-mRNA-splicing factor CWC22 homolog

2

1

High-throughput

0.549

High

1331863

EI2BG
Translation initiation factor eIF2B subunit gamma

2

3

High-throughput

0.549

High

1331874

EI2BD
Translation initiation factor eIF2B subunit delta

2

5

High-throughput

0.549

High

1331879

STX8
Syntaxin-8

1

0

High-throughput

0.546

High

49972

RHG10
Rho GTPase-activating protein 10

1

1

High-throughput

0.536

High

355008

CHK2
Serine/threonine-protein kinase Chk2

1

1

High-throughput

0.536

High

541592

FGFR1
Fibroblast growth factor receptor 1

1

4

High-throughput

0.536

High

1034178

ROR1
Inactive tyrosine-protein kinase transmembrane receptor ROR1

1

7

High-throughput

0.536

High

1129923

KANK1
KN motif and ankyrin repeat domain-containing protein 1

1

2

High-throughput

0.536

High

1331827

MADD
MAP kinase-activating death domain protein

1

4

High-throughput

0.536

High

1331845

APBA2
Amyloid-beta A4 precursor protein-binding family A member 2

1

2

High-throughput

0.536

High

1331849

NAA15
N-alpha-acetyltransferase 15, NatA auxiliary subunit

1

3

High-throughput

0.536

High

1198135

RHG29
Rho GTPase-activating protein 29

1

2

High-throughput

0.514

High

187142

PPM1G
Protein phosphatase 1G

1

0

High-throughput

0.513

High

732644

ARRB2
Beta-arrestin-2

1

0

High-throughput

0.513

High

936660

BRPF1
Peregrin

1

0

High-throughput

0.513

High

1239628

JMJD6
Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

1

0

High-throughput

0.513

High

1331820

CAMKV
CaM kinase-like vesicle-associated protein

1

0

High-throughput

0.513

High

1331821

PI42C
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma

1

0

High-throughput

0.513

High

1331831

CSN5
COP9 signalosome complex subunit 5

1

0

High-throughput

0.513

High

1331853

ADNP
Activity-dependent neuroprotector homeobox protein

1

0

High-throughput

0.513

High

1331883

EXOG
Nuclease EXOG, mitochondrial

1

0

High-throughput

0.513

High

1331851

THS7B
Thrombospondin type-1 domain-containing protein 7B

1

0

High-throughput

0.493

High

175908

SET1A
Histone-lysine N-methyltransferase SETD1A

1

1

High-throughput

0.489

High

274195

ANR17
Ankyrin repeat domain-containing protein 17

1

1

High-throughput

0.489

High

280729

PR40A
Pre-mRNA-processing factor 40 homolog A

1

1

High-throughput

0.489

High

348166

M4K4
Mitogen-activated protein kinase kinase kinase kinase 4

1

3

High-throughput

0.489

High

839906

AF9
Protein AF-9

1

3

High-throughput

0.489

High

883284

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

2

High-throughput

0.489

High

908301

AFF3
AF4/FMR2 family member 3

1

2

High-throughput

0.489

High

958671

CSN2
COP9 signalosome complex subunit 2

1

1

High-throughput

0.489

High

1103491

AP3B2
AP-3 complex subunit beta-2

1

4

High-throughput

0.489

High

1114942

CUL4A
Cullin-4A

1

4

High-throughput

0.489

High

1115302

CUL4B
Cullin-4B

1

4

High-throughput

0.489

High

1121050

BOP1
Ribosome biogenesis protein BOP1

1

1

High-throughput

0.489

High

1228307

UTP25
U3 small nucleolar RNA-associated protein 25 homolog

1

1

High-throughput

0.489

High

1243827

CTR9
RNA polymerase-associated protein CTR9 homolog

1

1

High-throughput

0.489

High

1258778

UB2R2
Ubiquitin-conjugating enzyme E2 R2

1

2

High-throughput

0.489

High

1278762

HDGR2
Hepatoma-derived growth factor-related protein 2

1

1

High-throughput

0.489

High

1331828

SMG7
Nonsense-mediated mRNA decay factor SMG7

1

1

High-throughput

0.489

High

1331838

BOD1
Biorientation of chromosomes in cell division protein 1

1

1

High-throughput

0.489

High

1331839

DCAF5
DDB1- and CUL4-associated factor 5

1

3

High-throughput

0.489

High

1331843

LENG8
Leukocyte receptor cluster member 8

1

1

High-throughput

0.489

High

1331858

CSN7B
COP9 signalosome complex subunit 7b

1

1

High-throughput

0.489

High

1331871

CSN7A
COP9 signalosome complex subunit 7a

1

1

High-throughput

0.489

High

1331873

AFF4
AF4/FMR2 family member 4

1

3

High-throughput

0.489

High

1331880

CSN3
COP9 signalosome complex subunit 3

1

2

High-throughput

0.489

High

1331881

SMG5
Nonsense-mediated mRNA decay factor SMG5

1

1

High-throughput

0.489

High

1331884

ARI1
E3 ubiquitin-protein ligase ARIH1

1

4

High-throughput

0.489

High

250711

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

6

Small-scale

0.457

High

208536

PJA2
E3 ubiquitin-protein ligase Praja-2

1

1

High-throughput

0.445

High

255127

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

5

High-throughput

0.445

High

283707

GPC4
Glypican-4

1

3

High-throughput

0.445

High

298991

TSN9
Tetraspanin-9

1

2

High-throughput

0.445

High

530088

TAU
Microtubule-associated protein tau

1

8

High-throughput

0.445

High

726678

SDC4
Syndecan-4

1

3

High-throughput

0.445

High

760476

SDC2
Syndecan-2

1

3

High-throughput

0.445

High

762351

GPC1
Glypican-1 [Cleaved into: Secreted glypican-1]

1

3

High-throughput

0.445

High

948877

CD81
CD81 antigen

1

2

High-throughput

0.445

High

1119208

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

12

High-throughput

0.445

High

1152784

PI5PA
Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A

1

1

High-throughput

0.445

High

1271246

SV2B
Synaptic vesicle glycoprotein 2B

1

5

High-throughput

0.445

High

1272705

MAEA
E3 ubiquitin-protein transferase MAEA

1

6

High-throughput

0.445

High

106282

APRIO
Alternative prion protein

1

3

High-throughput

0.437

High

1316108

K319L
Dyslexia-associated protein KIAA0319-like protein

1

0

High-throughput

0.426

High

1331824

PNISR
Arginine/serine-rich protein PNISR

1

0

High-throughput

0.426

High

1331854

PININ
Pinin

1

0

High-throughput

0.426

High

1331877

ACINU
Apoptotic chromatin condensation inducer in the nucleus

1

0

High-throughput

0.426

High

1331882

CBPC1
Cytosolic carboxypeptidase 1

1

0

High-throughput

0.426

High

324016

CSTN1
Calsyntenin-1

1

5

High-throughput

0.407

High

714272

PML
Protein PML

1

1

High-throughput

0.407

High

934861

TERA
Transitional endoplasmic reticulum ATPase

1

3

High-throughput

0.407

High

1145277

RNPS1
RNA-binding protein with serine-rich domain 1

1

1

High-throughput

0.407

High

1215327

DCAF8
DDB1- and CUL4-associated factor 8

1

2

High-throughput

0.407

High

1252751

RN111
E3 ubiquitin-protein ligase Arkadia

1

1

High-throughput

0.407

High

1290590

ZCH18
Zinc finger CCCH domain-containing protein 18

1

1

High-throughput

0.407

High

1331856

WDR26
WD repeat-containing protein 26

1

2

High-throughput

0.407

High

1331857

RMD5A
E3 ubiquitin-protein transferase RMND5A

1

4

High-throughput

0.407

High

1331867

GID8
Glucose-induced degradation protein 8 homolog

1

6

High-throughput

0.407

High

1331878

MKLN1
Muskelin

1

4

High-throughput

0.407

High

702519

ACADL
Long-chain specific acyl-CoA dehydrogenase, mitochondrial

3

0

High-throughput

0.342

High

1249548

TM107
Transmembrane protein 107

2

0

High-throughput

0.316

High

1331819

T229B
Transmembrane protein 229B

2

0

High-throughput

0.316

High

1331840

CKLF3
CKLF-like MARVEL transmembrane domain-containing protein 3

2

0

High-throughput

0.316

High

1331848

FUND2
FUN14 domain-containing protein 2

2

0

High-throughput

0.316

High

1331869

CC167
Coiled-coil domain-containing protein 167

2

0

High-throughput

0.316

High

1134488

NOLC1
Nucleolar and coiled-body phosphoprotein 1

2

0

High-throughput

0.313

High

1331832

ARK2N
Protein ARK2N

2

0

High-throughput

0.313

High

1331846

CYBC1
Cytochrome b-245 chaperone 1

2

0

High-throughput

0.313

High

1331864

RAD18
E3 ubiquitin-protein ligase RAD18

2

0

High-throughput

0.313

High

1331866

WDR70
WD repeat-containing protein 70

2

0

High-throughput

0.313

High

1331876

GPTC8
G patch domain-containing protein 8

2

0

High-throughput

0.313

High

216012

FIBP
Acidic fibroblast growth factor intracellular-binding protein

1

0

High-throughput

0.279

Low

282607

ERN1
Serine/threonine-protein kinase/endoribonuclease IRE1

1

0

High-throughput

0.279

Low

320724

UBXN7
UBX domain-containing protein 7

1

0

High-throughput

0.279

Low

844263

MTHR
Methylenetetrahydrofolate reductase

1

0

High-throughput

0.279

Low

889151

RBM25
RNA-binding protein 25

1

0

High-throughput

0.279

Low

1249388

CWC27
Spliceosome-associated protein CWC27 homolog

1

0

High-throughput

0.279

Low

1251729

CERS6
Ceramide synthase 6

1

0

High-throughput

0.279

Low

1272487

CSN6
COP9 signalosome complex subunit 6

1

0

High-throughput

0.279

Low

1281064

UB2Q1
Ubiquitin-conjugating enzyme E2 Q1

1

0

High-throughput

0.279

Low

1322535

MIER1
Mesoderm induction early response protein 1

1

0

High-throughput

0.279

Low

1329569

CA052
UPF0690 protein C1orf52

1

0

High-throughput

0.279

Low

1330540

PAF1
RNA polymerase II-associated factor 1 homolog

1

0

High-throughput

0.279

Low

1331822

TM10A
tRNA methyltransferase 10 homolog A

1

0

High-throughput

0.279

Low

1331825

LEO1
RNA polymerase-associated protein LEO1

1

0

High-throughput

0.279

Low

1331833

EAF2
ELL-associated factor 2

1

0

High-throughput

0.279

Low

1331847

CSN4
COP9 signalosome complex subunit 4

1

0

High-throughput

0.279

Low

1331855

WDR55
WD repeat-containing protein 55

1

0

High-throughput

0.279

Low

1331859

GPBL1
Vasculin-like protein 1

1

0

High-throughput

0.279

Low

1331862

IFT46
Intraflagellar transport protein 46 homolog

1

0

High-throughput

0.279

Low

1331865

GPTC2
G patch domain-containing protein 2

1

0

High-throughput

0.279

Low

1331868

DCA16
DDB1- and CUL4-associated factor 16

1

0

High-throughput

0.279

Low

1331875

DACH1
Dachshund homolog 1

1

0

High-throughput

0.279

Low

1331885

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

0

High-throughput

0.279

Low

475402

RS17
Small ribosomal subunit protein eS17

1

0

High-throughput

0.249

Low

1134989

CUL7
Cullin-7

1

0

High-throughput

0.249

Low

125960

SMAP
Small acidic protein

1

0

High-throughput

0.232

Low

568681

GYS1
Glycogen [starch] synthase, muscle

1

0

High-throughput

0.232

Low

604701

UBF1
Nucleolar transcription factor 1

1

0

High-throughput

0.232

Low

863420

GLYG
Glycogenin-1

1

0

High-throughput

0.232

Low

884366

UBE2A
Ubiquitin-conjugating enzyme E2 A

1

0

High-throughput

0.232

Low

1307883

ARMC8
Armadillo repeat-containing protein 8

1

0

High-throughput

0.232

Low

1309291

GID4
Glucose-induced degradation protein 4 homolog

1

0

High-throughput

0.232

Low

1331823

G6PT3
Glucose-6-phosphate exchanger SLC37A2

1

0

High-throughput

0.232

Low

1331830

GGH
Gamma-glutamyl hydrolase

1

0

High-throughput

0.232

Low

1331841

SORC2
VPS10 domain-containing receptor SorCS2 [Cleaved into: SorCS2 122 kDa chain; SorCS2 104 kDa chain; SorCS2 18 kDa chain]

1

0

High-throughput

0.232

Low

1331870

EXTL2
Exostosin-like 2

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025