Protein: SYT1
Synaptotagmin-1 (Synaptotagmin I) (SytI) (p65)

Gene: SYT1
Organism: Homo sapiens
Interactions: 110
UniProt ID: P21579

Gene Ontology (top 5):
GO:0000149 - SNARE binding
GO:0001786 - phosphatidylserine binding
GO:0005509 - calcium ion binding
GO:0005513 - detection of calcium ion
GO:0005516 - calmodulin binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

136166

SYT5
Synaptotagmin-5

3

17

High-throughput

0.861

High

639149

SYT2
Synaptotagmin-2

3

19

High-throughput

0.855

High

639152

BT2A2
Butyrophilin subfamily 2 member A2

2

2

High-throughput

0.783

High

639135

STX1A
Syntaxin-1A

2

8

Small-scale

0.778

High

639163

S10AD
Protein S100-A13

2

0

Small-scale

0.716

High

639115

SNP25
Synaptosomal-associated protein 25

4

8

Small-scale

0.680

High

639110

EI2BB
Translation initiation factor eIF2B subunit beta

3

5

High-throughput

0.662

High

639118

VLDLR
Very low-density lipoprotein receptor

3

4

High-throughput

0.662

High

639126

EI2BE
Translation initiation factor eIF2B subunit epsilon

3

3

High-throughput

0.662

High

639171

EI2BG
Translation initiation factor eIF2B subunit gamma

3

3

High-throughput

0.662

High

639178

EI2BD
Translation initiation factor eIF2B subunit delta

3

5

High-throughput

0.662

High

639106

STX2
Syntaxin-2

1

8

Small-scale

0.647

High

639124

STX4
Syntaxin-4

1

8

Small-scale

0.647

High

639127

STX3
Syntaxin-3

1

8

Small-scale

0.647

High

639153

STON2
Stonin-2

3

4

Small-scale

0.646

High

639136

DGUOK
Deoxyguanosine kinase, mitochondrial

3

0

High-throughput

0.638

High

639172

KTU
Protein kintoun

3

0

High-throughput

0.638

High

639177

NUFP1
FMR1-interacting protein NUFIP1

3

0

High-throughput

0.638

High

426936

FGF1
Fibroblast growth factor 1

1

0

Small-scale

0.614

High

639103

MIP
Lens fiber major intrinsic protein

2

1

High-throughput

0.606

High

639104

HMOX2
Heme oxygenase 2

2

1

High-throughput

0.606

High

639125

BNIP2
BCL2/adenovirus E1B 19 kDa protein-interacting protein 2

2

1

High-throughput

0.606

High

639165

SNAB
Beta-soluble NSF attachment protein

2

1

High-throughput

0.606

High

639169

CWC22
Pre-mRNA-splicing factor CWC22 homolog

3

1

High-throughput

0.604

High

639182

RRP7A
Ribosomal RNA-processing protein 7 homolog A

2

0

High-throughput

0.602

High

639185

NEMO
NF-kappa-B essential modulator

1

3

High-throughput

0.594

High

327164

ZFPL1
Zinc finger protein-like 1

2

0

High-throughput

0.580

High

639183

UBIA1
UbiA prenyltransferase domain-containing protein 1

2

0

High-throughput

0.580

High

639138

RHG29
Rho GTPase-activating protein 29

1

2

High-throughput

0.575

High

451682

PGK2
Phosphoglycerate kinase 2

2

1

High-throughput

0.574

High

596957

TSHR
Thyrotropin receptor

1

0

High-throughput

0.558

High

208962

CYB5B
Cytochrome b5 type B

2

1

High-throughput

0.553

High

131547

CACB4
Voltage-dependent L-type calcium channel subunit beta-4

1

1

Small-scale

0.552

High

639134

SMAD2
Mothers against decapentaplegic homolog 2

1

0

High-throughput

0.537

High

164900

TR10C
Tumor necrosis factor receptor superfamily member 10C

1

1

High-throughput

0.536

High

477402

CD63
CD63 antigen

1

2

High-throughput

0.536

High

529074

TAU
Microtubule-associated protein tau

1

8

High-throughput

0.536

High

639107

SDC2
Syndecan-2

1

3

High-throughput

0.536

High

639119

LRP2
Low-density lipoprotein receptor-related protein 2

1

4

High-throughput

0.536

High

639120

ANK2
Ankyrin-2

1

1

High-throughput

0.536

High

639128

BLMH
Bleomycin hydrolase

1

1

High-throughput

0.536

High

639180

MCTS1
Malignant T-cell-amplified sequence 1

1

1

High-throughput

0.536

High

639184

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

1

High-throughput

0.536

High

105330

APRIO
Alternative prion protein

2

3

High-throughput

0.533

High

639150

GOLM1
Golgi membrane protein 1

1

0

High-throughput

0.518

High

639112

GPM6A
Neuronal membrane glycoprotein M6-a

1

0

High-throughput

0.513

High

139681

CAC1A
Voltage-dependent P/Q-type calcium channel subunit alpha-1A

1

12

Small-scale

0.501

High

639167

DNJC5
DnaJ homolog subfamily C member 5

1

3

High-throughput

0.501

High

639158

RBM18
Probable RNA-binding protein 18

1

1

High-throughput

0.489

High

639170

CHD8
Chromodomain-helicase-DNA-binding protein 8

1

2

High-throughput

0.489

High

639155

CBP
CREB-binding protein

1

1

Small-scale

0.481

High

639109

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

0

High-throughput

0.480

High

639161

RBM14
RNA-binding protein 14

1

0

Small-scale

0.480

High

411346

NTRK1
High affinity nerve growth factor receptor

1

8

High-throughput

0.479

High

421495

A4
Amyloid-beta precursor protein

1

8

Small-scale

0.479

High

639111

RB27A
Ras-related protein Rab-27A

1

19

Small-scale

0.479

High

639117

VAMP2
Vesicle-associated membrane protein 2

1

4

Small-scale

0.479

High

639131

RB33A
Ras-related protein Rab-33A

1

5

Small-scale

0.479

High

639137

SV2C
Synaptic vesicle glycoprotein 2C

1

5

Small-scale

0.479

High

639143

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.479

High

639144

SV2B
Synaptic vesicle glycoprotein 2B

1

5

Small-scale

0.479

High

639146

SMC5
Structural maintenance of chromosomes protein 5

1

1

High-throughput

0.479

High

620129

NUCL
Nucleolin

1

0

High-throughput

0.458

High

639140

A16L1
Autophagy-related protein 16-1

1

0

Small-scale

0.458

High

250455

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

6

Small-scale

0.457

High

639113

CACB3
Voltage-dependent L-type calcium channel subunit beta-3

1

1

Small-scale

0.457

High

639121

FMR1
Fragile X messenger ribonucleoprotein 1

1

3

High-throughput

0.457

High

126057

AP3B1
AP-3 complex subunit beta-1

1

4

High-throughput

0.445

High

159147

ABLM1
Actin-binding LIM protein 1

1

1

High-throughput

0.445

High

254805

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

5

High-throughput

0.445

High

283655

GPC4
Glypican-4

1

3

High-throughput

0.445

High

323962

CSTN1
Calsyntenin-1

1

5

High-throughput

0.445

High

404666

PRIO
Major prion protein

1

1

High-throughput

0.445

High

639105

SDC4
Syndecan-4

1

3

High-throughput

0.445

High

639108

GPC1
Glypican-1 [Cleaved into: Secreted glypican-1]

1

3

High-throughput

0.445

High

639114

TERA
Transitional endoplasmic reticulum ATPase

1

3

High-throughput

0.445

High

639122

ZO1
Tight junction protein 1

1

3

High-throughput

0.445

High

639129

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

12

High-throughput

0.445

High

639132

EI2BA
Translation initiation factor eIF2B subunit alpha

1

5

High-throughput

0.445

High

639133

PI5PA
Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A

1

1

High-throughput

0.445

High

639142

RBP10
Ran-binding protein 10

1

3

High-throughput

0.445

High

639145

MAEA
E3 ubiquitin-protein transferase MAEA

1

6

High-throughput

0.445

High

639147

SYNPO
Synaptopodin

1

1

High-throughput

0.445

High

639156

TRI44
Tripartite motif-containing protein 44

1

2

High-throughput

0.445

High

639159

NAF1
H/ACA ribonucleoprotein complex non-core subunit NAF1

1

1

High-throughput

0.445

High

639160

BOD1
Biorientation of chromosomes in cell division protein 1

1

1

High-throughput

0.445

High

639164

M3K5
Mitogen-activated protein kinase kinase kinase 5

1

3

High-throughput

0.445

High

639168

WDR26
WD repeat-containing protein 26

1

2

High-throughput

0.445

High

639174

GID8
Glucose-induced degradation protein 8 homolog

1

6

High-throughput

0.445

High

639176

WRP73
WD repeat-containing protein WRAP73

1

1

High-throughput

0.445

High

639179

MKLN1
Muskelin

1

4

High-throughput

0.445

High

639181

SET1B
Histone-lysine N-methyltransferase SETD1B

1

1

High-throughput

0.445

High

531189

CMGA
Chromogranin-A

1

1

Small-scale

0.437

High

636039

CD11B
Cyclin-dependent kinase 11B

1

0

High-throughput

0.426

High

335301

M3K6
Mitogen-activated protein kinase kinase kinase 6

1

3

High-throughput

0.407

High

451480

CENPB
Major centromere autoantigen B

1

1

High-throughput

0.407

High

639154

RTF1
RNA polymerase-associated protein RTF1 homolog

1

1

High-throughput

0.407

High

124233

HAX1
HCLS1-associated protein X-1

3

0

High-throughput

0.347

High

639173

ARMC1
Armadillo repeat-containing protein 1

3

0

High-throughput

0.347

High

639139

BOREA
Borealin

2

0

High-throughput

0.328

High

639148

CGAT2
Chondroitin sulfate N-acetylgalactosaminyltransferase 2

2

0

High-throughput

0.316

High

639151

TM254
Transmembrane protein 254

2

0

High-throughput

0.316

High

639157

GIMA5
GTPase IMAP family member 5

2

0

High-throughput

0.316

High

639166

TMM60
Transmembrane protein 60

2

0

High-throughput

0.316

High

639175

TM14C
Transmembrane protein 14C

2

0

High-throughput

0.316

High

639162

SIN3A
Paired amphipathic helix protein Sin3a

1

0

Small-scale

0.275

Low

639116

PHS
Pterin-4-alpha-carbinolamine dehydratase

1

0

High-throughput

0.249

Low

639123

TFCP2
Alpha-globin transcription factor CP2

1

0

High-throughput

0.249

Low

639130

PEBB
Core-binding factor subunit beta

1

0

High-throughput

0.249

Low

639141

CF015
Uncharacterized protein C6orf15

1

0

Small-scale

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025