HitPredict

Interactor 1: M4K1 (P70218)
Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (Hematopoietic progenitor kinase) (HPK) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1)
Gene: Map4k1

Interactor 2: LCP2 (Q60787)
Lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76 kDa) (SLP-76 tyrosine phosphoprotein) (SLP76)
Gene: LCP2

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	11487585, 24584089
Identification Methods	affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0035556 - intracellular signal transduction
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 827 Mm			1 533
+	Mm
		1141383 M4K3_MOUSE (7-825): 0: 852: 42.74		LCP2_MOUSE (1-533): 2.96e-77: 254: 100.00
+	Hs
		1024138 M4K3_HUMAN (7-825): 0: 852: 42.52		LCP2_HUMAN (1-531): 2.21e-75: 249: 80.98
+	Mm
		936331 M4K1_MOUSE (1-827): 0: 862: 100.00		BLNK_MOUSE (52-520): 1.69e-35: 140: 21.62
+	Hs
		1261028 M4K1_HUMAN (1-825): 0: 818: 83.07		BLNK_HUMAN (52-520): 3.13e-36: 142: 22.80
+	Hs
		1186099 AKT3_HUMAN (9-345): 1.5e-129: 397: 22.99		MICA3_HUMAN (54-405): 3.78e-26: 115: 12.64
+	Hs
		1233556 STK26_HUMAN (12-348): 2.89e-117: 363: 38.89		MINK1_HUMAN (115-411): 2.89e-21: 100: 14.98
+	Hs
		1233560 TNIK_HUMAN (11-296): 3.69e-63: 233: 42.76		MINK1_HUMAN (115-411): 2.89e-21: 100: 14.98
+	Hs
		1233520 MINK1_HUMAN (11-296): 6.14e-59: 220: 42.57		MINK1_HUMAN (115-411): 2.89e-21: 100: 14.98
+	Hs
		1356429 TNIK_HUMAN (11-296): 3.69e-63: 233: 42.76		PCLO_HUMAN (56-399): 1.66e-09: 63.2: 9.22
+	Mm
		102652 TNIK_MOUSE (11-296): 4.08e-63: 233: 42.76		G3X972_MOUSE (54-448): 3.55e-09: 61.7: 10.60