HitPredict

Interactor 1: TCPB (P78371)
T-complex protein 1 subunit beta (TCP-1-beta) (CCT-beta) (Chaperonin containing T-complex polypeptide 1 subunit 2)
Gene: CCT2

Interactor 2: HUWE1 (Q7Z6Z7)
E3 ubiquitin-protein ligase HUWE1 (EC 2.3.2.26) (ARF-binding protein 1) (ARF-BP1) (HECT, UBA and WWE domain-containing protein 1) (HECT-type E3 ubiquitin transferase HUWE1) (Homologous to E6AP carboxyl terminus homologous protein 9) (HectH9) (Large structure of UREB1) (LASU1) (Mcl-1 ubiquitin ligase E3) (Mule) (Upstream regulatory element-binding protein 1) (URE-B1) (URE-binding protein 1)
Gene: HUWE1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	25147182
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005576 - extracellular region GO:0005829 - cytosol GO:0070062 - extracellular exosome
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 535 Hs			1 4374
+	Hs
		1192186 TCPH_HUMAN (4-532): 0: 591: 34.08		HUWE1_HUMAN (1-4374): 0: 3240: 100.00
+	Hs
		826741 TCPG_HUMAN (3-532): 0: 561: 28.33		HUWE1_HUMAN (1-4374): 0: 3240: 100.00
+	Hs
		573339 TCPA_HUMAN (5-533): 0: 541: 34.30		HUWE1_HUMAN (1-4374): 0: 3240: 100.00
+	Hs
		821288 TCPE_HUMAN (1-528): 0: 541: 32.29		HUWE1_HUMAN (1-4374): 0: 3240: 100.00
+	Hs
		1306694 TCPH_HUMAN (4-532): 0: 591: 34.08		SMUF1_HUMAN (3772-4371): 0: 620: 32.84
+	Hs
		125363 TCPB_HUMAN (1-535): 0: 586: 100.00		WWP2_HUMAN (3506-4372): 0: 624: 24.57
+	Hs
		943497 TCPB_HUMAN (1-535): 0: 586: 100.00		SMUF1_HUMAN (3772-4371): 0: 620: 32.84
+	Hs
		125246 TCPG_HUMAN (3-532): 0: 561: 28.33		WWP2_HUMAN (3506-4372): 0: 624: 24.57
+	Hs
		125243 TCPE_HUMAN (1-528): 0: 541: 32.29		WWP2_HUMAN (3506-4372): 0: 624: 24.57
+	Hs
		573490 TCPA_HUMAN (5-533): 0: 541: 34.30		SMUF1_HUMAN (3772-4371): 0: 620: 32.84
+	Sc
		760677 TCPB_YEAST (9-532): 0: 566: 65.71		TOM1_YEAST (3831-4374): 1.99e-157: 554: 43.77
+	Sc
		792404 TCPH_YEAST (1-532): 0: 559: 33.09		TOM1_YEAST (3831-4374): 1.99e-157: 554: 43.77
+	Sc
		760801 TCPG_YEAST (5-528): 0: 537: 28.33		TOM1_YEAST (3831-4374): 1.99e-157: 554: 43.77