HitPredict

Interactor 1: F1M9D6 (F1M9D6)
Signal transducer and activator of transcription
Gene: Stat1

Interactor 2: INSR (P15127)
Insulin receptor (IR) (EC 2.7.10.1) (CD antigen CD220) [Cleaved into: Insulin receptor subunit alpha; Insulin receptor subunit beta]
Gene: INSR

Species: Rattus norvegicus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	30300385
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	SH2~fn3, PK_Tyr_Ser-Thr~SH2, STAT_alpha~fn3
Common GO terms	GO:0008284 - positive regulation of cell population proliferation GO:0030424 - axon GO:0032869 - cellular response to insulin stimulus GO:0045893 - positive regulation of DNA-templated transcription
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 755 Rn			1 1383
+	Hs
		411328 STAT3_HUMAN (1-750): 0: 868: 51.91		INSR_HUMAN (27-1383): 0: 1527: 95.43
+	Hs
		411341 STA5B_HUMAN (1-754): 0: 788: 28.84		INSR_HUMAN (27-1383): 0: 1527: 95.43
+	Hs
		435568 STAT3_HUMAN (1-750): 0: 868: 51.91		IGF1R_HUMAN (13-1381): 0: 1302: 55.77
+	Hs
		776626 STAT3_HUMAN (1-750): 0: 868: 51.91		EPHA5_HUMAN (662-1320): 0: 581: 24.11
+	Hs
		849879 STA5B_HUMAN (1-754): 0: 788: 28.84		EPHA4_HUMAN (662-1328): 0: 570: 24.19
+	Hs
		855286 STAT2_HUMAN (1-753): 0: 782: 42.50		EPHB4_HUMAN (662-1321): 3.03e-170: 536: 24.96
+	Hs
		384428 STAT1_HUMAN (1-755): 0: 1019: 92.86		NTRK1_HUMAN (997-1287): 1.6e-65: 240: 41.95
+	Hs
		338072 STAT1_HUMAN (1-755): 0: 1019: 92.86		EGFR_HUMAN (32-308): 1.21e-29: 130: 22.50
+	Hs
		776856 STAT3_HUMAN (1-750): 0: 868: 51.91		ALK_HUMAN (997-1340): 6.12e-71: 264: 41.57
+	Hs
		383667 STAT1_HUMAN (1-755): 0: 1019: 92.86		ERBB2_HUMAN (32-342): 4.75e-18: 92.8: 19.83
+	Hs
		384414 STAT3_HUMAN (1-750): 0: 868: 51.91		NTRK1_HUMAN (997-1287): 1.6e-65: 240: 41.95
+	Hs
		609197 STAT3_HUMAN (1-750): 0: 868: 51.91		FGFR3_HUMAN (1016-1288): 2.88e-60: 224: 40.07
+	Hs
		384522 STA5B_HUMAN (1-754): 0: 788: 28.84		NTRK1_HUMAN (997-1287): 1.6e-65: 240: 41.95
+	Hs
		338060 STAT3_HUMAN (1-750): 0: 868: 51.91		EGFR_HUMAN (32-308): 1.21e-29: 130: 22.50
+	Mm
		786519 STAT3_MOUSE (1-750): 0: 869: 51.91		ERBB2_MOUSE (23-317): 1.45e-23: 110: 20.70
+	Hs
		383662 STAT3_HUMAN (1-750): 0: 868: 51.91		ERBB2_HUMAN (32-342): 4.75e-18: 92.8: 19.83
+	Hs
		338153 STA5B_HUMAN (1-754): 0: 788: 28.84		EGFR_HUMAN (32-308): 1.21e-29: 130: 22.50
+	Hs
		338166 STAT2_HUMAN (1-753): 0: 782: 42.50		EGFR_HUMAN (32-308): 1.21e-29: 130: 22.50
+	Hs
		849893 STA5B_HUMAN (1-754): 0: 788: 28.84		ERBB4_HUMAN (44-347): 2.97e-26: 119: 20.42
+	Hs
		338073 STA5A_HUMAN (1-753): 0: 766: 28.03		EGFR_HUMAN (32-308): 1.21e-29: 130: 22.50