Protein: EMSY
BRCA2-interacting transcriptional repressor EMSY

Gene: EMSY
Organism: Homo sapiens
Interactions: 139
UniProt ID: Q7Z589

Gene Ontology (top 5):
GO:0005654 - nucleoplasm
GO:0006281 - DNA repair
GO:0006325 - chromatin organization
GO:0006355 - regulation of DNA-templated transcription
GO:0042802 - identical protein binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1014142

CBX1
Chromobox protein homolog 1

3

8

Small-scale

0.891

High

1109847

HDAC1
Histone deacetylase 1

7

8

High-throughput

0.746

High

1278983

MO4L1
Mortality factor 4-like protein 1

7

4

Small-scale

0.745

High

1278956

GATD1
GATA zinc finger domain-containing protein 1

6

0

High-throughput

0.697

High

274346

SIN3B
Paired amphipathic helix protein Sin3b

4

6

High-throughput

0.694

High

1158896

RBBP7
Histone-binding protein RBBP7

4

18

High-throughput

0.683

High

775438

DDIT3
DNA damage-inducible transcript 3 protein

3

1

High-throughput

0.675

High

1136806

MO4L2
Mortality factor 4-like protein 2

4

4

Small-scale

0.672

High

1278958

HDAC2
Histone deacetylase 2

3

8

High-throughput

0.656

High

1278963

PHF12
PHD finger protein 12

3

16

High-throughput

0.656

High

1278944

EMSY
BRCA2-interacting transcriptional repressor EMSY

1

14

High-throughput

0.618

High

711830

KDM5A
Lysine-specific demethylase 5A

2

9

High-throughput

0.611

High

1278982

ASH2L
Set1/Ash2 histone methyltransferase complex subunit ASH2

2

16

Small-scale

0.611

High

224014

GET3
ATPase GET3

2

1

High-throughput

0.606

High

680927

PSA1
Proteasome subunit alpha type-1

2

7

High-throughput

0.606

High

1233744

CNDH2
Condensin-2 complex subunit H2

2

0

High-throughput

0.602

High

372427

MYC
Myc proto-oncogene protein

2

15

High-throughput

0.584

High

1278954

NUP43
Nucleoporin Nup43

2

20

High-throughput

0.584

High

904321

BRCA2
Breast cancer type 2 susceptibility protein

1

1

Small-scale

0.573

High

1146241

ZMY11
Zinc finger MYND domain-containing protein 11

1

16

Small-scale

0.573

High

174444

ZN646
Zinc finger protein 646

1

2

High-throughput

0.573

High

1278975

ZN335
Zinc finger protein 335

1

1

Small-scale

0.573

High

396414

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

913783

ZN131
Zinc finger protein 131

1

7

High-throughput

0.561

High

1278977

DISC1
Disrupted in schizophrenia 1 protein

2

2

High-throughput

0.553

High

502033

H2AZ
Histone H2A.Z

1

15

High-throughput

0.536

High

625467

CSK22
Casein kinase II subunit alpha'

1

14

High-throughput

0.536

High

1029707

FOXK2
Forkhead box protein K2

1

16

High-throughput

0.536

High

1066366

RBBP4
Histone-binding protein RBBP4

1

15

High-throughput

0.536

High

1123018

FHL2
Four and a half LIM domains protein 2

1

13

High-throughput

0.536

High

1145485

RBBP5
Retinoblastoma-binding protein 5

1

20

Small-scale

0.536

High

1250601

BCOR
BCL-6 corepressor

1

20

Small-scale

0.536

High

1278950

CCAR2
Cell cycle and apoptosis regulator protein 2

1

2

Small-scale

0.536

High

1278973

NUCKS
Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1

1

2

High-throughput

0.536

High

1278981

FOXJ2
Forkhead box protein J2

1

15

High-throughput

0.536

High

1278986

KCC2A
Calcium/calmodulin-dependent protein kinase type II subunit alpha

1

3

High-throughput

0.536

High

1133494

NFIX
Nuclear factor 1 X-type

2

20

High-throughput

0.533

High

595493

H15
Histone H1.5

1

10

High-throughput

0.515

High

728315

AKT1
RAC-alpha serine/threonine-protein kinase

1

5

Small-scale

0.501

High

549627

PRPS2
Ribose-phosphate pyrophosphokinase 2

1

2

High-throughput

0.489

High

909064

NEK4
Serine/threonine-protein kinase Nek4

1

9

High-throughput

0.489

High

930961

HSP72
Heat shock-related 70 kDa protein 2

1

8

High-throughput

0.489

High

1089222

TRI26
Tripartite motif-containing protein 26

1

5

High-throughput

0.489

High

1178596

KIF7
Kinesin-like protein KIF7

1

5

High-throughput

0.489

High

1278955

FBLI1
Filamin-binding LIM protein 1

1

6

High-throughput

0.489

High

129218

MEN1
Menin

1

5

High-throughput

0.479

High

143080

NFIB
Nuclear factor 1 B-type

1

20

High-throughput

0.479

High

229037

AKAP8
A-kinase anchor protein 8

1

2

High-throughput

0.479

High

283499

TAD2A
Transcriptional adapter 2-alpha

1

7

High-throughput

0.479

High

331094

KI20A
Kinesin-like protein KIF20A

1

15

High-throughput

0.479

High

339790

KLF8
Krueppel-like factor 8

1

20

High-throughput

0.479

High

414108

P53
Cellular tumor antigen p53

1

8

High-throughput

0.479

High

474091

NFIC
Nuclear factor 1 C-type

1

20

High-throughput

0.479

High

485670

RU2A
U2 small nuclear ribonucleoprotein A'

1

6

High-throughput

0.479

High

519396

MYB
Transcriptional activator Myb

1

5

High-throughput

0.479

High

520164

ANDR
Androgen receptor

1

20

High-throughput

0.479

High

538425

EGR2
E3 SUMO-protein ligase EGR2

1

8

High-throughput

0.479

High

540900

ERG
Transcriptional regulator ERG

1

20

High-throughput

0.479

High

558234

XRCC6
X-ray repair cross-complementing protein 6

1

9

High-throughput

0.479

High

577458

ETS1
Protein C-ets-1

1

20

High-throughput

0.479

High

589034

RFA2
Replication protein A 32 kDa subunit

1

9

High-throughput

0.479

High

675563

TYY1
Transcriptional repressor protein YY1

1

10

High-throughput

0.479

High

714229

PML
Protein PML

1

15

High-throughput

0.479

High

739002

ELF1
ETS-related transcription factor Elf-1

1

20

High-throughput

0.479

High

768534

RFA3
Replication protein A 14 kDa subunit

1

8

High-throughput

0.479

High

775564

NU214
Nuclear pore complex protein Nup214

1

14

High-throughput

0.479

High

799245

BRCA1
Breast cancer type 1 susceptibility protein

1

14

High-throughput

0.479

High

833982

HNF4A
Hepatocyte nuclear factor 4-alpha

1

20

High-throughput

0.479

High

837060

ELK3
ETS domain-containing protein Elk-3

1

20

High-throughput

0.479

High

879226

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

12

High-throughput

0.479

High

886994

CEBPA
CCAAT/enhancer-binding protein alpha

1

13

High-throughput

0.479

High

910565

HNRPM
Heterogeneous nuclear ribonucleoprotein M

1

4

High-throughput

0.479

High

915988

NUP98
Nuclear pore complex protein Nup98-Nup96

1

8

High-throughput

0.479

High

944691

KLF3
Krueppel-like factor 3

1

20

High-throughput

0.479

High

979897

H4
Histone H4

1

9

High-throughput

0.479

High

1016982

H33
Histone H3.3

1

19

High-throughput

0.479

High

1029107

E2F1
Transcription factor E2F1

1

10

High-throughput

0.479

High

1048019

TLE3
Transducin-like enhancer protein 3

1

15

High-throughput

0.479

High

1087830

NFIA
Nuclear factor 1 A-type

1

20

High-throughput

0.479

High

1088893

TP53B
TP53-binding protein 1

1

13

High-throughput

0.479

High

1100063

TIF1B
Transcription intermediary factor 1-beta

1

15

High-throughput

0.479

High

1118657

KLF9
Krueppel-like factor 9

1

20

High-throughput

0.479

High

1119572

NFYC
Nuclear transcription factor Y subunit gamma

1

3

High-throughput

0.479

High

1129641

MDC1
Mediator of DNA damage checkpoint protein 1

1

20

High-throughput

0.479

High

1152706

ELF2
ETS-related transcription factor Elf-2

1

20

High-throughput

0.479

High

1186487

CHD9
Chromodomain-helicase-DNA-binding protein 9

1

11

High-throughput

0.479

High

1278945

NAA40
N-alpha-acetyltransferase 40

1

4

High-throughput

0.479

High

1278947

FOXP4
Forkhead box protein P4

1

19

Small-scale

0.479

High

1278948

SMC5
Structural maintenance of chromosomes protein 5

1

11

High-throughput

0.479

High

1278949

SLX4
Structure-specific endonuclease subunit SLX4

1

15

High-throughput

0.479

High

1278953

PHC3
Polyhomeotic-like protein 3

1

15

High-throughput

0.479

High

1278961

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

17

High-throughput

0.479

High

1278962

MBD6
Methyl-CpG-binding domain protein 6

1

12

High-throughput

0.479

High

1278966

ELF4
ETS-related transcription factor Elf-4

1

20

High-throughput

0.479

High

1278967

KLF6
Krueppel-like factor 6

1

20

High-throughput

0.479

High

1278969

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

8

High-throughput

0.479

High

1278970

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

2

High-throughput

0.479

High

1278971

WWTR1
WW domain-containing transcription regulator protein 1

1

15

High-throughput

0.479

High

1278972

BRD8
Bromodomain-containing protein 8

1

20

High-throughput

0.479

High

1278974

FOXP1
Forkhead box protein P1

1

16

Small-scale

0.479

High

1278978

MRGBP
MRG/MORF4L-binding protein

1

2

High-throughput

0.479

High

1278979

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

3

High-throughput

0.479

High

1278980

RTEL1
Regulator of telomere elongation helicase 1

1

2

High-throughput

0.479

High

1278984

KLF15
Krueppel-like factor 15

1

20

High-throughput

0.479

High

1278985

ZMYD8
MYND-type zinc finger-containing chromatin reader ZMYND8

1

12

Small-scale

0.479

High

1278987

ASF1A
Histone chaperone ASF1A

1

7

High-throughput

0.479

High

1278988

ZN281
Zinc finger protein 281

1

5

High-throughput

0.479

High

1278989

KLF12
Krueppel-like factor 12

1

20

High-throughput

0.479

High

1278990

MOFA1
MORF4 family-associated protein 1

1

1

High-throughput

0.479

High

578509

BRAF
Serine/threonine-protein kinase B-raf

1

5

High-throughput

0.462

High

298015

SPF27
Pre-mRNA-splicing factor SPF27

1

0

High-throughput

0.458

High

1278946

PALB2
Partner and localizer of BRCA2

1

0

High-throughput

0.458

High

1278964

NUP88
Nuclear pore complex protein Nup88

1

0

High-throughput

0.458

High

94369

D6RA96
Regulator of telomere elongation helicase 1

1

2

High-throughput

0.445

High

537416

HSP7C
Heat shock cognate 71 kDa protein

1

8

High-throughput

0.445

High

542090

TOP1
DNA topoisomerase 1

1

2

High-throughput

0.445

High

1013078

HMGN5
High mobility group nucleosome-binding domain-containing protein 5

1

2

High-throughput

0.445

High

1134628

NUMA1
Nuclear mitotic apparatus protein 1

1

13

High-throughput

0.445

High

1163018

H2B2E
Histone H2B type 2-E

1

20

High-throughput

0.445

High

190071

FOXP2
Forkhead box protein P2

1

20

Small-scale

0.437

High

436917

K1C18
Keratin, type I cytoskeletal 18

1

3

High-throughput

0.437

High

615409

SON
Protein SON

1

14

High-throughput

0.437

High

786698

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

10

High-throughput

0.437

High

1178134

QSER1
Glutamine and serine-rich protein 1

1

14

High-throughput

0.437

High

1276419

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

11

High-throughput

0.437

High

1278965

FEV
Protein FEV

1

20

High-throughput

0.437

High

1278968

KLF16
Krueppel-like factor 16

1

20

High-throughput

0.437

High

1278960

DDT4L
DNA damage-inducible transcript 4-like protein

1

3

High-throughput

0.417

High

1161920

H31T
Histone H3.1t

1

19

High-throughput

0.408

High

761736

HSP74
Heat shock 70 kDa protein 4

1

13

High-throughput

0.407

High

1156125

ZYX
Zyxin

1

11

High-throughput

0.407

High

1278952

GG6L2
Golgin subfamily A member 6-like protein 2

1

18

High-throughput

0.407

High

1278976

LN28A
Protein lin-28 homolog A

1

2

High-throughput

0.407

High

1278957

TM171
Transmembrane protein 171

3

0

High-throughput

0.347

High

1211383

CLVS2
Clavesin-2

2

0

High-throughput

0.316

High

1278951

LIX1
Protein limb expression 1 homolog

2

0

High-throughput

0.316

High

1278959

AIDA
Axin interactor, dorsalization-associated protein

2

0

High-throughput

0.316

High

991871

DYLT1
Dynein light chain Tctex-type 1

2

0

High-throughput

0.305

High


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Last updated: 11Aug2025