Protein: RTEL1
Regulator of telomere elongation helicase 1 (EC 5.6.2.-) (Novel helicase-like)

Gene: RTEL1
Organism: Homo sapiens
Interactions: 90
UniProt ID: Q9NZ71

Gene Ontology (top 5):
GO:0000723 - telomere maintenance
GO:0000732 - DNA strand displacement
GO:0000781 - chromosome, telomeric region
GO:0003677 - DNA binding
GO:0003678 - DNA helicase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1403599

MMS19
MMS19 nucleotide excision repair protein homolog

5

4

Small-scale

0.706

High

1314453

SLX4
Structure-specific endonuclease subunit SLX4

3

1

Small-scale

0.669

High

960592

PSME3
Proteasome activator complex subunit 3

3

2

High-throughput

0.667

High

239231

ZNRD2
Protein ZNRD2

2

1

High-throughput

0.628

High

1114484

CUL3
Cullin-3

2

3

High-throughput

0.611

High

1292818

SKAP1
Src kinase-associated phosphoprotein 1

2

3

High-throughput

0.611

High

154896

ISLR
Immunoglobulin superfamily containing leucine-rich repeat protein

3

1

High-throughput

0.609

High

1360014

LIPH
Lipase member H

3

1

High-throughput

0.609

High

457746

TBB5
Tubulin beta chain

2

0

High-throughput

0.602

High

1453085

NGN3
Neurogenin-3

2

0

High-throughput

0.602

High

1144192

TEBP
Prostaglandin E synthase 3

2

1

High-throughput

0.601

High

777027

PPM1A
Protein phosphatase 1A

2

0

High-throughput

0.585

High

1411847

ZNG1A
Zinc-regulated GTPase metalloprotein activator 1A

2

0

High-throughput

0.585

High

1153490

EFNB3
Ephrin-B3

2

2

High-throughput

0.574

High

1333051

GALD1
Glutamine amidotransferase-like class 1 domain-containing protein 1

2

1

High-throughput

0.574

High

1453084

CIA2B
Cytosolic iron-sulfur assembly component 2B

2

6

Small-scale

0.571

High

139422

VMA5A
von Willebrand factor A domain-containing protein 5A

1

2

High-throughput

0.536

High

158511

RFXK
DNA-binding protein RFXANK

1

2

High-throughput

0.536

High

549701

PRPS2
Ribose-phosphate pyrophosphokinase 2

1

2

High-throughput

0.536

High

922287

LIMK1
LIM domain kinase 1

1

1

High-throughput

0.536

High

1042092

LMNB2
Lamin-B2

1

2

High-throughput

0.536

High

1054659

PSME1
Proteasome activator complex subunit 1

1

2

High-throughput

0.536

High

1233808

CNDH2
Condensin-2 complex subunit H2

1

1

High-throughput

0.536

High

1382545

TRI52
E3 ubiquitin-protein ligase TRIM52

1

1

High-throughput

0.536

High

1434762

CIA2A
Cytosolic iron-sulfur assembly component 2A

1

6

High-throughput

0.536

High

261563

B4GT2
Beta-1,4-galactosyltransferase 2

1

0

High-throughput

0.513

High

282493

KTNA1
Katanin p60 ATPase-containing subunit A1

1

0

High-throughput

0.513

High

559524

XRCC5
X-ray repair cross-complementing protein 5

1

0

High-throughput

0.513

High

594117

NCK1
SH2/SH3 adapter protein NCK1

1

0

High-throughput

0.513

High

777574

K22E
Keratin, type II cytoskeletal 2 epidermal

1

0

High-throughput

0.513

High

1383877

EFMT3
EEF1A lysine methyltransferase 3

1

0

High-throughput

0.513

High

1403177

INT14
Integrator complex subunit 14

1

0

High-throughput

0.513

High

1420241

UBXN6
UBX domain-containing protein 6

1

0

High-throughput

0.513

High

190503

COPT1
High affinity copper uptake protein 1

1

2

High-throughput

0.489

High

933238

SLUR1
Secreted Ly-6/uPAR-related protein 1

1

1

High-throughput

0.489

High

1060925

LRP1
Prolow-density lipoprotein receptor-related protein 1

1

1

High-throughput

0.489

High

1328139

TTC9C
Tetratricopeptide repeat protein 9C

1

3

High-throughput

0.489

High

294439

CD123
Translation initiation factor eIF2 assembly protein

1

1

High-throughput

0.479

High

430441

JUN
Transcription factor Jun

1

1

High-throughput

0.479

High

589889

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.479

High

696707

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.479

High

756074

MCM5
DNA replication licensing factor MCM5

1

1

Small-scale

0.479

High

769365

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.479

High

1055988

RAD51
DNA repair protein RAD51 homolog 1

1

3

High-throughput

0.479

High

1060499

DPOE1
DNA polymerase epsilon catalytic subunit A

1

1

Small-scale

0.479

High

1278980

EMSY
BRCA2-interacting transcriptional repressor EMSY

1

2

High-throughput

0.479

High

1316780

WDFY3
WD repeat and FYVE domain-containing protein 3

1

2

High-throughput

0.479

High

1389083

THA11
THAP domain-containing protein 11

1

1

High-throughput

0.479

High

1433457

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

1

High-throughput

0.479

High

1446646

AT132
Polyamine-transporting ATPase 13A2

1

1

High-throughput

0.479

High

1452243

AATF
Protein AATF

1

1

High-throughput

0.479

High

1453080

NDUAD
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13

1

1

High-throughput

0.479

High

159887

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

0

High-throughput

0.458

High

281259

CDC45
Cell division control protein 45 homolog

1

0

Small-scale

0.458

High

288526

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

1

0

Small-scale

0.458

High

352571

TOP3B
DNA topoisomerase 3-beta-1

1

0

High-throughput

0.458

High

1226545

DCA15
DDB1- and CUL4-associated factor 15

1

0

High-throughput

0.458

High

1369966

XPF
DNA repair endonuclease XPF

1

0

Small-scale

0.458

High

1411972

PSF3
DNA replication complex GINS protein PSF3

1

0

Small-scale

0.458

High

944088

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

1

High-throughput

0.445

High

302987

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

1

6

High-throughput

0.437

High

324271

FA13A
Protein FAM13A

1

1

High-throughput

0.437

High

888488

TSP3
Thrombospondin-3

1

2

High-throughput

0.437

High

913683

VAV2
Guanine nucleotide exchange factor VAV2

1

1

High-throughput

0.437

High

914220

EFNA3
Ephrin-A3

1

2

High-throughput

0.437

High

1294019

ANKL2
Ankyrin repeat and LEM domain-containing protein 2

1

1

High-throughput

0.437

High

1330638

CCYL1
Cyclin-Y-like protein 1

1

1

High-throughput

0.437

High

1404989

GA2L1
GAS2-like protein 1

1

1

High-throughput

0.437

High

1453083

S18L2
SS18-like protein 2

1

1

High-throughput

0.437

High

1453086

TEST
Testisin

1

1

High-throughput

0.437

High

1253670

PKHG7
Pleckstrin homology domain-containing family G member 7

1

2

High-throughput

0.407

High

1453081

PP4RL
Putative serine/threonine-protein phosphatase 4 regulatory subunit 1-like

1

3

High-throughput

0.407

High

1211765

UBX11
UBX domain-containing protein 11

3

0

High-throughput

0.347

High

72434

MI4GD
MIF4G domain-containing protein

1

0

High-throughput

0.279

Low

260807

RAMP2
Receptor activity-modifying protein 2

1

0

High-throughput

0.279

Low

295648

CIB2
Calcium and integrin-binding family member 2

1

0

High-throughput

0.279

Low

296838

ST1C4
Sulfotransferase 1C4

1

0

High-throughput

0.279

Low

656027

CAH6
Carbonic anhydrase 6

1

0

High-throughput

0.279

Low

926858

VMAT1
Chromaffin granule amine transporter

1

0

High-throughput

0.279

Low

1142533

PDCD1
Programmed cell death protein 1

1

0

High-throughput

0.279

Low

1248207

SAS6
Spindle assembly abnormal protein 6 homolog

1

0

High-throughput

0.279

Low

1258845

CYS1
Cystin-1

1

0

High-throughput

0.279

Low

1292420

OSTM1
Osteopetrosis-associated transmembrane protein 1

1

0

High-throughput

0.279

Low

1325848

D2HDH
D-2-hydroxyglutarate dehydrogenase, mitochondrial

1

0

High-throughput

0.279

Low

1452120

ARL15
ADP-ribosylation factor-like protein 15

1

0

High-throughput

0.279

Low

1453082

HCST
Hematopoietic cell signal transducer

1

0

High-throughput

0.279

Low

1398520

ZDH15
Palmitoyltransferase ZDHHC15

1

0

Small-scale

0.249

Low

516932

CB27B
Putative uncharacterized protein CDRT15P3

1

0

High-throughput

0.232

Low

1081722

YL016
Putative uncharacterized protein LOC100128554

1

0

High-throughput

0.232

Low

1185875

NSN5B
Putative NOL1/NOP2/Sun domain family member 5B

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025