Interactor 1: SESN3 (P58005)
Sestrin-3 (EC 1.11.1.-)
Gene: SESN3
Interactor 2: NPRL3 (Q12980)
GATOR1 complex protein NPRL3 (-14 gene protein) (Alpha-globin regulatory element-containing gene protein) (Nitrogen permease regulator 3-like protein) (Protein CGTHBA)
Gene: NPRL3
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.50 | 0.60 | 0.550 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 25263562 |
| Identification Methods | pull down, anti tag coimmunoprecipitation |
| Interaction Type | direct interaction, association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | - |
| Common GO terms | GO:0034198 - cellular response to amino acid starvation GO:1904262 - negative regulation of TORC1 signaling |
| Homologous interactions | 1 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 11Aug2025
