Protein: NPRL3
GATOR1 complex protein NPRL3 (-14 gene protein) (Alpha-globin regulatory element-containing gene protein) (Nitrogen permease regulator 3-like protein) (Protein CGTHBA)

Gene: NPRL3
Organism: Homo sapiens
Interactions: 75
UniProt ID: Q12980

Gene Ontology (top 5):
GO:0003281 - ventricular septum development
GO:0005096 - GTPase activator activity
GO:0005765 - lysosomal membrane
GO:0010508 - positive regulation of autophagy
GO:0034198 - cellular response to amino acid starvation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1091890

NPRL2
GATOR1 complex protein NPRL2

8

2

Small-scale

0.966

High

271353

DEPD5
GATOR1 complex protein DEPDC5

6

2

Small-scale

0.735

High

1091898

WDR24
GATOR2 complex protein WDR24

5

4

Small-scale

0.718

High

1091886

RRAGA
Ras-related GTP-binding protein A

4

2

Small-scale

0.676

High

945664

SESN2
Sestrin-2

2

1

Small-scale

0.634

High

1091884

WDR59
GATOR2 complex protein WDR59

3

6

Small-scale

0.633

High

1060866

LRP1
Prolow-density lipoprotein receptor-related protein 1

2

0

High-throughput

0.602

High

1091876

SAMTR
S-adenosylmethionine sensor upstream of mTORC1

2

0

High-throughput

0.602

High

1091881

SZT2
KICSTOR complex protein SZT2

2

0

Small-scale

0.585

High

1091917

KPTN
KICSTOR complex protein kaptin

2

0

Small-scale

0.585

High

945687

SESN3
Sestrin-3

1

1

Small-scale

0.550

High

1017772

CCZ1B
Vacuolar fusion protein CCZ1 homolog B

1

0

High-throughput

0.513

High

1091893

ITFG2
KICSTOR complex protein ITFG2

1

0

High-throughput

0.513

High

1091907

RRAGC
Ras-related GTP-binding protein C

1

2

Small-scale

0.479

High

1091908

RRAGD
Ras-related GTP-binding protein D

1

2

Small-scale

0.479

High

1091910

MIOS
GATOR2 complex protein MIOS

1

2

Small-scale

0.479

High

540428

LAMP1
Lysosome-associated membrane glycoprotein 1

1

0

Small-scale

0.458

High

838931

RHG25
Rho GTPase-activating protein 25

1

0

High-throughput

0.458

High

1091874

FHL3
Four and a half LIM domains protein 3

1

1

High-throughput

0.439

High

1091892

APBP2
Amyloid protein-binding protein 2

1

1

High-throughput

0.439

High

186743

P73
Tumor protein p73

1

3

High-throughput

0.437

High

413734

P53
Cellular tumor antigen p53

1

3

High-throughput

0.437

High

1091905

P63
Tumor protein 63

1

3

High-throughput

0.437

High

302051

SEGN
Secretagogin

3

0

High-throughput

0.347

High

1091885

LYPD4
Ly6/PLAUR domain-containing protein 4

2

0

High-throughput

0.328

High

1091896

ZN414
Zinc finger protein 414

2

0

High-throughput

0.318

High

1091904

CHIA
Acidic mammalian chitinase

2

0

High-throughput

0.318

High

64864

RCCD1
RCC1 domain-containing protein 1

1

0

High-throughput

0.279

Low

158434

RFXK
DNA-binding protein RFXANK

1

0

High-throughput

0.279

Low

249463

ACSL4
Long-chain-fatty-acid--CoA ligase 4

1

0

High-throughput

0.279

Low

295576

CIB2
Calcium and integrin-binding family member 2

1

0

High-throughput

0.279

Low

296701

TUSC2
Tumor suppressor candidate 2

1

0

High-throughput

0.279

Low

296771

ST1C4
Sulfotransferase 1C4

1

0

High-throughput

0.279

Low

334177

ATG7
Ubiquitin-like modifier-activating enzyme ATG7

1

0

High-throughput

0.279

Low

441478

AGAL
Alpha-galactosidase A

1

0

High-throughput

0.279

Low

457399

TBB5
Tubulin beta chain

1

0

High-throughput

0.279

Low

605998

CAN2
Calpain-2 catalytic subunit

1

0

High-throughput

0.279

Low

777451

K22E
Keratin, type II cytoskeletal 2 epidermal

1

0

High-throughput

0.279

Low

783569

MP2K2
Dual specificity mitogen-activated protein kinase kinase 2

1

0

High-throughput

0.279

Low

930867

HSP72
Heat shock-related 70 kDa protein 2

1

0

High-throughput

0.279

Low

1037062

OC90
Otoconin-90

1

0

High-throughput

0.279

Low

1041745

PPARD
Peroxisome proliferator-activated receptor delta

1

0

High-throughput

0.279

Low

1091873

SG2A2
Mammaglobin-A

1

0

High-throughput

0.279

Low

1091875

SF3B3
Splicing factor 3B subunit 3

1

0

High-throughput

0.279

Low

1091877

INF2
Inverted formin-2

1

0

High-throughput

0.279

Low

1091879

AMZ1
Archaemetzincin-1

1

0

High-throughput

0.279

Low

1091880

EFMT2
EEF1A lysine methyltransferase 2

1

0

High-throughput

0.279

Low

1091882

SPRY7
SPRY domain-containing protein 7

1

0

High-throughput

0.279

Low

1091883

SWAP1
ATPase SWSAP1

1

0

High-throughput

0.279

Low

1091887

CPNE9
Copine-9

1

0

High-throughput

0.279

Low

1091888

KLH34
Kelch-like protein 34

1

0

High-throughput

0.279

Low

1091889

D2HDH
D-2-hydroxyglutarate dehydrogenase, mitochondrial

1

0

High-throughput

0.279

Low

1091891

ASB13
Ankyrin repeat and SOCS box protein 13

1

0

High-throughput

0.279

Low

1091894

EFMT3
EEF1A lysine methyltransferase 3

1

0

High-throughput

0.279

Low

1091897

ARL5B
ADP-ribosylation factor-like protein 5B

1

0

High-throughput

0.279

Low

1091899

METH
Methionine synthase

1

0

High-throughput

0.279

Low

1091900

ZNG1A
Zinc-regulated GTPase metalloprotein activator 1A

1

0

High-throughput

0.279

Low

1091901

THTPA
Thiamine-triphosphatase

1

0

High-throughput

0.279

Low

1091902

TCAB1
Telomerase Cajal body protein 1

1

0

High-throughput

0.279

Low

1091903

DUS16
Dual specificity protein phosphatase 16

1

0

High-throughput

0.279

Low

1091906

PIGU
GPI-anchor transamidase component PIGU

1

0

High-throughput

0.279

Low

1091909

PYRG2
CTP synthase 2

1

0

High-throughput

0.279

Low

1091912

WRP73
WD repeat-containing protein WRAP73

1

0

High-throughput

0.279

Low

1091914

DD19B
ATP-dependent RNA helicase DDX19B

1

0

High-throughput

0.279

Low

1091916

PKHM1
Pleckstrin homology domain-containing family M member 1

1

0

Small-scale

0.279

Low

1091895

DDX11
ATP-dependent DNA helicase DDX11

1

0

High-throughput

0.269

Low

507897

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

0

High-throughput

0.261

Low

241540

PRKN
E3 ubiquitin-protein ligase parkin

1

0

High-throughput

0.249

Low

519995

ANDR
Androgen receptor

1

0

High-throughput

0.249

Low

1091913

FEM1B
Protein fem-1 homolog B

1

0

Small-scale

0.249

Low

1091915

CARD8
Caspase recruitment domain-containing protein 8

1

0

High-throughput

0.249

Low

222070

NCK2
Cytoplasmic protein NCK2

1

0

High-throughput

0.232

Low

856662

BAG6
Large proline-rich protein BAG6

1

0

High-throughput

0.232

Low

1091878

NSN5B
Putative NOL1/NOP2/Sun domain family member 5B

1

0

High-throughput

0.232

Low

1091911

UTP6
U3 small nucleolar RNA-associated protein 6 homolog

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025